Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              20     509
NP_002935                                                              17    2528
NP_112181                                                              17    2528
XP_006715611                                                           17    2528
NP_620130                                                              16    5631
XP_006719005                                                           16    5631
XP_005271789                                                           16    5631
XP_005271787                                                           16    5631
XP_005271786                                                           16    5631
XP_005271785                                                           16    5631
XP_005271784                                                           16    5631
NP_060417                                                              16    7355
NP_000426                                                              15    9605
NP_835260                                                              15    9605
XP_005259981                                                           15    9605
XP_006722352                                                           15    9605
XP_006722351                                                           15    9605
XP_006714523                                                           15    9605
XP_005248329                                                           15    9605
XP_005248328                                                           15    9605
XP_006714522                                                           15    9605
XP_006714521                                                           15    9605
XP_006714520                                                           15    9605
XP_005248327                                                           15    9605
XP_005248326                                                           15    9605
XP_006714519                                                           15    9605

>NP_005179
          Length = 906

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PAMLARRTL 9
           PA+LARRTL
Sbjct: 782 PAVLARRTL 790



>NP_002935
          Length = 2347

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    PAMLARRTL 9
            PAMLA +TL
Sbjct: 1377 PAMLAGKTL 1385



>NP_112181
          Length = 615

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   AMLARRTL 9
           AML+RRTL
Sbjct: 577 AMLSRRTL 584



>XP_006715611
          Length = 2342

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    PAMLARRTL 9
            PAMLA +TL
Sbjct: 1372 PAMLAGKTL 1380



>NP_620130
          Length = 664

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P ML RR+L
Sbjct: 271 PVMLPRRSL 279



>XP_006719005
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P ML RR+L
Sbjct: 274 PVMLPRRSL 282



>XP_005271789
          Length = 349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P ML RR+L
Sbjct: 274 PVMLPRRSL 282



>XP_005271787
          Length = 412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PAMLARRTL 9
          P ML RR+L
Sbjct: 19 PVMLPRRSL 27



>XP_005271786
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P ML RR+L
Sbjct: 134 PVMLPRRSL 142



>XP_005271785
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P ML RR+L
Sbjct: 134 PVMLPRRSL 142



>XP_005271784
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P ML RR+L
Sbjct: 274 PVMLPRRSL 282



>NP_060417
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAMLARRTL 9
           PA++ RR+L
Sbjct: 521 PAVMGRRSL 529



>NP_000426
          Length = 2321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            PA+LAR  L
Sbjct: 1505 PALLARGVL 1513



>NP_835260
          Length = 2839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1790 PKMIARRPI 1798



>XP_005259981
          Length = 2269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            PA+LAR  L
Sbjct: 1453 PALLARGVL 1461



>XP_006722352
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P M+A+R L
Sbjct: 109 PQMIAKRVL 117



>XP_006722351
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PAMLARRTL 9
           P M+A+R L
Sbjct: 109 PQMIAKRVL 117



>XP_006714523
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1459 PKMIARRPI 1467



>XP_005248329
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1616 PKMIARRPI 1624



>XP_005248328
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1616 PKMIARRPI 1624



>XP_006714522
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1636 PKMIARRPI 1644



>XP_006714521
          Length = 2781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1698 PKMIARRPI 1706



>XP_006714520
          Length = 2802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1719 PKMIARRPI 1727



>XP_005248327
          Length = 2839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1790 PKMIARRPI 1798



>XP_005248326
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1790 PKMIARRPI 1798



>XP_006714519
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    PAMLARRTL 9
            P M+ARR +
Sbjct: 1790 PKMIARRPI 1798



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.135    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 295,212
Number of extensions: 308
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)