Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results 
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done




                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              19     869
NP_001091680                                                           19     869
NP_001091679                                                           19     869
XP_006713048                                                           19     869
XP_006713047                                                           19     869
XP_006713046                                                           19     869
XP_005264943                                                           19     869
NP_002221                                                              18    1482
NP_068831                                                              18    1482
XP_006721941                                                           18    1482
XP_006721940                                                           18    1482
XP_006721939                                                           18    1482
XP_006721938                                                           18    1482
XP_006721937                                                           18    1482
XP_006721936                                                           18    1482
XP_006721935                                                           18    1482
XP_006721934                                                           18    1482
XP_005257370                                                           18    1482
NP_055640                                                              17    4312
XP_005264554                                                           16    7355
XP_005264553                                                           16    7355
NP_002257                                                              15    9605
NP_036531                                                              15    9605
NP_001271207                                                           15    9605
NP_001271206                                                           15    9605
XP_006722986                                                           15    9605
XP_005259717                                                           15    9605
XP_005259716                                                           15    9605



>NP_001895
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PALVKMLAS 9
           PALVKML S
Sbjct: 238 PALVKMLGS 246





>NP_001091680
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PALVKMLAS 9
           PALVKML S
Sbjct: 238 PALVKMLGS 246





>NP_001091679
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PALVKMLAS 9
           PALVKML S
Sbjct: 238 PALVKMLGS 246





>XP_006713048
          Length = 720

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PALVKMLAS 9
           PALVKML S
Sbjct: 238 PALVKMLGS 246





>XP_006713047
          Length = 774

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PALVKMLAS 9
           PALVKML S
Sbjct: 231 PALVKMLGS 239





>XP_006713046
          Length = 774

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PALVKMLAS 9
           PALVKML S
Sbjct: 231 PALVKMLGS 239





>XP_005264943
          Length = 781

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PALVKMLAS 9
           PALVKML S
Sbjct: 238 PALVKMLGS 246





>NP_002221
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>NP_068831
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>XP_006721941
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>XP_006721940
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>XP_006721939
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>XP_006721938
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>XP_006721937
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>XP_006721936
          Length = 745

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 229 PALVRMLSS 237






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 483 PAIVKLL 489





>XP_006721935
          Length = 762

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 246 PALVRMLSS 254






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 500 PAIVKLL 506





>XP_006721934
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 267 PALVRMLSS 275






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 521 PAIVKLL 527





>XP_005257370
          Length = 783

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PALV+ML+S
Sbjct: 267 PALVRMLSS 275






 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   PALVKML 7
           PA+VK+L
Sbjct: 521 PAIVKLL 527





>NP_055640
          Length = 2271

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALVKMLAS 9
            P LVK+LA+
Sbjct: 1038 PVLVKLLAT 1046





>XP_005264554
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PAL+KM+++
Sbjct: 312 PALLKMVST 320





>XP_005264553
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   PALVKMLAS 9
           PAL+KM+++
Sbjct: 312 PALLKMVST 320





>NP_002257
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   PALVKMLAS 9
           PA + +LAS
Sbjct: 165 PAFISLLAS 173





>NP_036531
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PALVKMLA 8
          PA V+M+A
Sbjct: 69 PAFVRMIA 76





>NP_001271207
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PALVKMLA 8
          PA V+M+A
Sbjct: 71 PAFVRMIA 78





>NP_001271206
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  PALVKMLA 8
          PA V+M+A
Sbjct: 69 PAFVRMIA 76





>XP_006722986
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALVKMLAS 9
            PAL++ LAS
Sbjct: 1422 PALLQSLAS 1430





>XP_005259717
          Length = 1738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALVKMLAS 9
            PAL++ LAS
Sbjct: 1641 PALLQSLAS 1649





>XP_005259716
          Length = 1738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALVKMLAS 9
            PAL++ LAS
Sbjct: 1641 PALLQSLAS 1649





  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.126    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 303,332
Number of extensions: 482
Number of successful extensions: 39
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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