Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_005018                                                              19     869
NP_653252                                                              17    3301
XP_005251225                                                           17    3301
XP_006716483                                                           17    3301
XP_005251224                                                           17    3301
NP_000954                                                              17    4312
NP_542437                                                              16    5631
NP_061197                                                              16    5631
NP_542435                                                              16    5631
NP_542436                                                              16    5631
NP_006132                                                              16    5631
NP_258260                                                              16    5631
NP_001273086                                                           16    5631
XP_006714867                                                           16    5631
XP_006714866                                                           16    5631
XP_005268581                                                           16    5631
NP_005622                                                              16    7355
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    PALMVEKML 9
            PAL+VEKML
Sbjct: 3443 PALVVEKML 3451
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    PALMVEKML 9
            PAL+VEKML
Sbjct: 3443 PALVVEKML 3451
>NP_005018
          Length = 728

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALMVEKML 9
           PAL+VEK+L
Sbjct: 280 PALLVEKLL 288
>NP_653252
          Length = 1463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALMVEKML 9
            PALMVE ++
Sbjct: 1198 PALMVEDLI 1206
>XP_005251225
          Length = 848

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   PALMVEKML 9
           PALMVE ++
Sbjct: 583 PALMVEDLI 591
>XP_006716483
          Length = 1367

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALMVEKML 9
            PALMVE ++
Sbjct: 1102 PALMVEDLI 1110
>XP_005251224
          Length = 1439

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALMVEKML 9
            PALMVE ++
Sbjct: 1174 PALMVEDLI 1182
>NP_000954
          Length = 604

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PALMVEK 7
           PAL+VEK
Sbjct: 491 PALLVEK 497
>NP_542437
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALMVEKML 9
           A+M+EKM+
Sbjct: 566 AVMIEKMI 573
>NP_061197
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALMVEKML 9
           A+M+EKM+
Sbjct: 566 AVMIEKMI 573
>NP_542435
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALMVEKML 9
           A+M+EKM+
Sbjct: 566 AVMIEKMI 573
>NP_542436
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ALMVEKML 9
           A+M+EKM+
Sbjct: 566 AVMIEKMI 573
>NP_006132
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PALMVEK 7
           PAL+VEK
Sbjct: 299 PALVVEK 305
>NP_258260
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   PALMVEKML 9
           P+L+VE++L
Sbjct: 600 PSLLVEELL 608
>NP_001273086
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   PALMVEK 7
           PAL+VEK
Sbjct: 222 PALVVEK 228
>XP_006714867
          Length = 632

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   PALMVEKML 9
           P+L+VE++L
Sbjct: 600 PSLLVEELL 608
>XP_006714866
          Length = 647

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   PALMVEKML 9
           P+L+VE++L
Sbjct: 557 PSLLVEELL 565
>XP_005268581
          Length = 688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   PALMVEKML 9
           P+L+VE++L
Sbjct: 598 PSLLVEELL 606
>NP_005622
          Length = 787

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PALMVEKM 8
           P+L+VEK+
Sbjct: 513 PSLLVEKI 520
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.135    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 413,125
Number of extensions: 499
Number of successful extensions: 19
Number of sequences better than 10000.0: 19
Number of HSP's gapped: 19
Number of HSP's successfully gapped: 19
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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