Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_116176                                                              18    1482
XP_005247896                                                           18    1482
XP_006713857                                                           18    1482
NP_001693                                                              17    2528
XP_005251072                                                           17    2528
NP_008862                                                              17    3301
NP_001273164                                                           17    3301
NP_001273166                                                           17    3301
NP_001273163                                                           17    3301
NP_001273162                                                           17    3301
NP_703150                                                              17    3301
XP_005253374                                                           17    3301
XP_005253372                                                           17    3301
XP_006710853                                                           17    3301
XP_006710852                                                           17    3301
XP_006710851                                                           17    3301
XP_006710850                                                           17    3301
XP_006710849                                                           17    3301
XP_005271124                                                           17    3301
XP_006710848                                                           17    3301
XP_006710847                                                           17    3301
XP_006710846                                                           17    3301
NP_001694                                                              17    3301
NP_940933                                                              15    9605
NP_056051                                                              15    9605
XP_006722513                                                           15    9605
XP_006722512                                                           15    9605
XP_006722510                                                           15    9605
XP_005266750                                                           15    9605
XP_005266749                                                           15    9605
XP_005266748                                                           15    9605
XP_005266747                                                           15    9605
XP_005253033                                                           15    9605
XP_005253030                                                           15    9605
XP_006714219                                                           15    9605
XP_006714218                                                           15    9605
XP_006714217                                                           15    9605
XP_006714216                                                           15    9605
NP_919227                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PA+MVAITV
Sbjct: 2861 PAIMVAITV 2869
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PA+MVAITV
Sbjct: 2656 PAIMVAITV 2664
>NP_116176
          Length = 797

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PA++VAITV
Sbjct: 578 PAIVVAITV 586
>XP_005247896
          Length = 502

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PA++VAITV
Sbjct: 283 PAIVVAITV 291
>XP_006713857
          Length = 560

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PA++VAITV
Sbjct: 341 PAIVVAITV 349
>NP_001693
          Length = 1584

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PAL+VAI+V
Sbjct: 1061 PALVVAISV 1069
>XP_005251072
          Length = 1586

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PAL+VAI+V
Sbjct: 1058 PALVVAISV 1066
>NP_008862
          Length = 496

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 8  PALIFAITV 16
>NP_001273164
          Length = 497

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 9  PALIFAITV 17
>NP_001273166
          Length = 535

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 47 PALIFAITV 55
>NP_001273163
          Length = 497

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 9  PALIFAITV 17
>NP_001273162
          Length = 520

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 32 PALIFAITV 40
>NP_703150
          Length = 520

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 32 PALIFAITV 40
>XP_005253374
          Length = 497

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 9  PALIFAITV 17
>XP_005253372
          Length = 497

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          PAL+ AITV
Sbjct: 9  PALIFAITV 17
>XP_006710853
          Length = 1478

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PAL+VA++V
Sbjct: 991 PALVVAVSV 999
>XP_006710852
          Length = 1497

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PAL+VA++V
Sbjct: 991 PALVVAVSV 999
>XP_006710851
          Length = 1511

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PAL+VA++V
Sbjct: 991 PALVVAVSV 999
>XP_006710850
          Length = 1530

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PAL+VA++V
Sbjct: 991 PALVVAVSV 999
>XP_006710849
          Length = 1530

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   PALMVAITV 9
           PAL+VA++V
Sbjct: 991 PALVVAVSV 999
>XP_005271124
          Length = 1551

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PAL+VA++V
Sbjct: 1046 PALVVAVSV 1054
>XP_006710848
          Length = 1552

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PAL+VA++V
Sbjct: 1046 PALVVAVSV 1054
>XP_006710847
          Length = 1566

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PAL+VA++V
Sbjct: 1046 PALVVAVSV 1054
>XP_006710846
          Length = 1584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PAL+VA++V
Sbjct: 1046 PALVVAVSV 1054
>NP_001694
          Length = 1585

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    PALMVAITV 9
            PAL+VA++V
Sbjct: 1046 PALVVAVSV 1054
>NP_940933
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LMVAITV 9
            LMVA+TV
Sbjct: 1056 LMVALTV 1062
>NP_056051
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PALMVAIT 8
           PAL+VA++
Sbjct: 991 PALIVAVS 998
>XP_006722513
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LMVAITV 9
           LMVA+TV
Sbjct: 696 LMVALTV 702
>XP_006722512
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LMVAITV 9
           LMVA+TV
Sbjct: 750 LMVALTV 756
>XP_006722510
          Length = 1054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LMVAITV 9
           LMVA+TV
Sbjct: 963 LMVALTV 969
>XP_005266750
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LMVAITV 9
            LMVA+TV
Sbjct: 1015 LMVALTV 1021
>XP_005266749
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LMVAITV 9
            LMVA+TV
Sbjct: 1056 LMVALTV 1062
>XP_005266748
          Length = 1136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LMVAITV 9
            LMVA+TV
Sbjct: 1056 LMVALTV 1062
>XP_005266747
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LMVAITV 9
            LMVA+TV
Sbjct: 1056 LMVALTV 1062
>XP_005253033
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          P+L++ ITV
Sbjct: 40 PSLLLTITV 48
>XP_005253030
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PALMVAITV 9
          P+L++ ITV
Sbjct: 40 PSLLLTITV 48
>XP_006714219
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PALMVAIT 8
           PAL+VA++
Sbjct: 557 PALIVAVS 564
>XP_006714218
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PALMVAIT 8
           PAL+VA++
Sbjct: 362 PALIVAVS 369
>XP_006714217
          Length = 1013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PALMVAIT 8
           PAL+VA++
Sbjct: 544 PALIVAVS 551
>XP_006714216
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   PALMVAIT 8
           PAL+VA++
Sbjct: 557 PALIVAVS 564
>NP_919227
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PALMVAI 7
          PAL+VA+
Sbjct: 40 PALLVAV 46
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.136    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 271,773
Number of extensions: 386
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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