Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              20     509
NP_001277155                                                           17    4312
NP_001277156                                                           17    4312
NP_055998                                                              17    4312
NP_001158136                                                           17    4312
XP_006714675                                                           17    4312
XP_006714673                                                           17    4312
XP_006714672                                                           17    4312
XP_006714670                                                           17    4312
XP_006714669                                                           17    4312
XP_006714668                                                           17    4312
XP_006714667                                                           17    4312
XP_006714666                                                           17    4312
XP_005248555                                                           17    4312
XP_006714665                                                           17    4312
NP_000426                                                              16    5631
NP_002038                                                              16    5631
NP_002935                                                              16    5631
XP_005259981                                                           16    5631
XP_006715611                                                           16    5631
NP_001548                                                              16    7355
NP_001161770                                                           16    7355
NP_004454                                                              16    7355
NP_066983                                                              16    7355
NP_060417                                                              16    7355
XP_005246588                                                           16    7355
XP_005246587                                                           16    7355
NP_001170986                                                           16    7355
NP_542189                                                              16    7355
NP_001167539                                                           15    9605
NP_001123368                                                           15    9605
NP_542775                                                              15    9605
NP_859052                                                              15    9605
NP_055529                                                              15    9605
NP_006827                                                              15    9605
NP_057419                                                              15    9605
XP_005276193                                                           15    9605
XP_006724998                                                           15    9605
XP_005262286                                                           15    9605
XP_006724781                                                           15    9605
XP_006724780                                                           15    9605
XP_005262283                                                           15    9605
XP_006721055                                                           15    9605
XP_006721054                                                           15    9605
XP_006721053                                                           15    9605
XP_006721052                                                           15    9605
XP_005271430                                                           15    9605
XP_006710440                                                           15    9605
NP_054735                                                              15    9605
NP_859069                                                              15    9605
>NP_005179
          Length = 906

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   PALLARRTL 9
           PA+LARRTL
Sbjct: 782 PAVLARRTL 790
>NP_001277155
          Length = 2417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1879 ALLARRSL 1886
>NP_001277156
          Length = 2362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1824 ALLARRSL 1831
>NP_055998
          Length = 2434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1896 ALLARRSL 1903
>NP_001158136
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 2085 ALLARRSL 2092
>XP_006714675
          Length = 2275

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1737 ALLARRSL 1744
>XP_006714673
          Length = 2362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1824 ALLARRSL 1831
>XP_006714672
          Length = 2414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1876 ALLARRSL 1883
>XP_006714670
          Length = 2425

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1887 ALLARRSL 1894
>XP_006714669
          Length = 2429

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1891 ALLARRSL 1898
>XP_006714668
          Length = 2429

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1891 ALLARRSL 1898
>XP_006714667
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1894 ALLARRSL 1901
>XP_006714666
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 1894 ALLARRSL 1901
>XP_005248555
          Length = 2626

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 2088 ALLARRSL 2095
>XP_006714665
          Length = 2651

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    ALLARRTL 9
            ALLARR+L
Sbjct: 2113 ALLARRSL 2120
>NP_000426
          Length = 2321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    PALLARRTL 9
            PALLAR  L
Sbjct: 1505 PALLARGVL 1513
>NP_002038
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  PALLARRTL 9
          P+LL RR+L
Sbjct: 28 PSLLLRRSL 36
>NP_002935
          Length = 2347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALLARRTL 9
            PA+LA +TL
Sbjct: 1377 PAMLAGKTL 1385
>XP_005259981
          Length = 2269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    PALLARRTL 9
            PALLAR  L
Sbjct: 1453 PALLARGVL 1461
>XP_006715611
          Length = 2342

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    PALLARRTL 9
            PA+LA +TL
Sbjct: 1372 PAMLAGKTL 1380
>NP_001548
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PALLARRTL 9
           P LL RRT+
Sbjct: 179 PVLLFRRTV 187
>NP_001161770
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PALLARRTL 9
           P LL RRT+
Sbjct: 179 PVLLFRRTV 187
>NP_004454
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PALLARR 7
          P LLARR
Sbjct: 40 PGLLARR 46
>NP_066983
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PALLARRT 8
           P LL RRT
Sbjct: 421 PVLLIRRT 428
>NP_060417
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PALLARRTL 9
           PA++ RR+L
Sbjct: 521 PAVMGRRSL 529
>XP_005246588
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PALLARRTL 9
           P LL RRT+
Sbjct: 179 PVLLFRRTV 187
>XP_005246587
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PALLARRTL 9
           P LL RRT+
Sbjct: 179 PVLLFRRTV 187
>NP_001170986
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PALLARRT 8
           P LL RRT
Sbjct: 388 PVLLIRRT 395
>NP_542189
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   PALLARRT 8
           P LL RRT
Sbjct: 313 PVLLLRRT 320
>NP_001167539
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLA+RTL
Sbjct: 435 SLLAQRTL 442
>NP_001123368
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLA+RTL
Sbjct: 435 SLLAQRTL 442
>NP_542775
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLA+RTL
Sbjct: 435 SLLAQRTL 442
>NP_859052
          Length = 698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PALLARRT 8
          PAL ARR+
Sbjct: 18 PALRARRS 25
>NP_055529
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PALLAR 6
            PALLAR
Sbjct: 1123 PALLAR 1128
>NP_006827
          Length = 2671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PALLAR 6
           PALLAR
Sbjct: 688 PALLAR 693
>NP_057419
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  PALLAR 6
          PALLAR
Sbjct: 83 PALLAR 88
>XP_005276193
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PALLARR 7
          PAL ARR
Sbjct: 76 PALAARR 82
>XP_006724998
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  PALLAR 6
          PALLAR
Sbjct: 83 PALLAR 88
>XP_005262286
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLA+RTL
Sbjct: 435 SLLAQRTL 442
>XP_006724781
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLA+RTL
Sbjct: 435 SLLAQRTL 442
>XP_006724780
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLA+RTL
Sbjct: 435 SLLAQRTL 442
>XP_005262283
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLA+RTL
Sbjct: 435 SLLAQRTL 442
>XP_006721055
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   PALLAR 6
           PALLAR
Sbjct: 334 PALLAR 339
>XP_006721054
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PALLAR 6
            PALLAR
Sbjct: 1123 PALLAR 1128
>XP_006721053
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PALLAR 6
            PALLAR
Sbjct: 1123 PALLAR 1128
>XP_006721052
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    PALLAR 6
            PALLAR
Sbjct: 1123 PALLAR 1128
>XP_005271430
          Length = 144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  PALLARR 7
          PAL ARR
Sbjct: 76 PALAARR 82
>XP_006710440
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  PALLARRTL 9
          P+LL+RR +
Sbjct: 5  PSLLSRRAV 13
>NP_054735
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ALLARRTL 9
           +LLARR+L
Sbjct: 401 SLLARRSL 408
>NP_859069
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PALLARRTL 9
          P LLAR +L
Sbjct: 58 PGLLARASL 66
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.141    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 375,226
Number of extensions: 524
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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