Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              18    1482
NP_005913                                                              18    1482
XP_005267046                                                           18    1482
XP_005267045                                                           18    1482
NP_570901                                                              17    4312
NP_060549                                                              17    4312
XP_006719395                                                           17    4312
XP_006716662                                                           17    4312
XP_005264455                                                           17    4312
NP_054752                                                              17    4312
NP_001124468                                                           16    5631
NP_000850                                                              16    5631
NP_003162                                                              16    5631
XP_005270125                                                           16    5631
NP_005468                                                              16    7355
NP_001186728                                                           16    7355
NP_001269462                                                           16    7355
NP_001186729                                                           16    7355
NP_787120                                                              16    7355
XP_005260950                                                           16    7355
XP_005260949                                                           16    7355
XP_005260948                                                           16    7355
XP_005260947                                                           16    7355
XP_006722782                                                           16    7355
XP_006713669                                                           16    7355
NP_036241                                                              16    7355
NP_001264084                                                           15    9605
NP_068506                                                              15    9605
NP_114434                                                              15    9605
NP_001034659                                                           15    9605
NP_001018098                                                           15    9605
NP_060154                                                              15    9605
NP_060550                                                              15    9605
NP_065872                                                              15    9605
NP_001094343                                                           15    9605
NP_689550                                                              15    9605
NP_055653                                                              15    9605
NP_659456                                                              15    9605
NP_001036009                                                           15    9605
NP_001036010                                                           15    9605
NP_003564                                                              15    9605
NP_849193                                                              15    9605
XP_005261932                                                           15    9605
XP_005255849                                                           15    9605
XP_005255848                                                           15    9605
XP_005252630                                                           15    9605
XP_005252629                                                           15    9605
XP_005252628                                                           15    9605
XP_005252627                                                           15    9605
XP_005252626                                                           15    9605
XP_005252625                                                           15    9605
XP_005252624                                                           15    9605
XP_005252623                                                           15    9605
XP_005252622                                                           15    9605
XP_006717555                                                           15    9605
XP_005252621                                                           15    9605
XP_006713080                                                           15    9605
>NP_006715
          Length = 1558

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PAGE SLLS
Sbjct: 639 PAGEPSLLS 647
>NP_005913
          Length = 1608

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PAGE SLLS
Sbjct: 639 PAGEPSLLS 647
>XP_005267046
          Length = 1554

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PAGE SLLS
Sbjct: 639 PAGEPSLLS 647
>XP_005267045
          Length = 1604

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PAGE SLLS
Sbjct: 639 PAGEPSLLS 647
>NP_570901
          Length = 647

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PAGELSLLS 9
          PAG LSLL+
Sbjct: 25 PAGLLSLLT 33
>NP_060549
          Length = 995

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   GELSLLS 9
           GELSLLS
Sbjct: 344 GELSLLS 350
>XP_006719395
          Length = 244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  PAGELSLL 8
          P+G+LSLL
Sbjct: 68 PSGKLSLL 75
>XP_006716662
          Length = 596

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  PAGELSLLS 9
          PAG LSLL+
Sbjct: 25 PAGLLSLLT 33
>XP_005264455
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   GELSLLS 9
           GELSLLS
Sbjct: 344 GELSLLS 350
>NP_054752
          Length = 244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  PAGELSLL 8
          P+G+LSLL
Sbjct: 68 PSGKLSLL 75
>NP_001124468
          Length = 835

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AGELSLLS 9
           AGELSL++
Sbjct: 795 AGELSLMA 802
>NP_000850
          Length = 888

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AGELSLLS 9
           AGELSL++
Sbjct: 848 AGELSLMA 855
>NP_003162
          Length = 786

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AGELSLLS 9
           AGELSL S
Sbjct: 728 AGELSLAS 735
>XP_005270125
          Length = 655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AGELSLLS 9
           AGELSL S
Sbjct: 597 AGELSLAS 604
>NP_005468
          Length = 1203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   PAGELSL 7
           P GELSL
Sbjct: 978 PPGELSL 984
>NP_001186728
          Length = 546

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  PAGELSLL 8
          PAG LSLL
Sbjct: 18 PAGCLSLL 25
>NP_001269462
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AGELSLL 8
           AGE+SLL
Sbjct: 400 AGEISLL 406
>NP_001186729
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  PAGELSLL 8
          PAG LSLL
Sbjct: 18 PAGCLSLL 25
>NP_787120
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  PAGELSLL 8
          PAG LSLL
Sbjct: 18 PAGCLSLL 25
>XP_005260950
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AGELSLL 8
           AGE+SLL
Sbjct: 446 AGEISLL 452
>XP_005260949
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AGELSLL 8
           AGE+SLL
Sbjct: 446 AGEISLL 452
>XP_005260948
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AGELSLL 8
           AGE+SLL
Sbjct: 455 AGEISLL 461
>XP_005260947
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AGELSLL 8
           AGE+SLL
Sbjct: 476 AGEISLL 482
>XP_006722782
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P+G LSLL
Sbjct: 143 PSGALSLL 150
>XP_006713669
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  PAGELSLL 8
          PAG LSLL
Sbjct: 18 PAGCLSLL 25
>NP_036241
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P+G LSLL
Sbjct: 143 PSGALSLL 150
>NP_001264084
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  PAGELSLL 8
          PAG +SLL
Sbjct: 36 PAGGVSLL 43
>NP_068506
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 581 PYGEISML 588
>NP_114434
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PAGELSLLS 9
          PA  L+LLS
Sbjct: 4  PAARLALLS 12
>NP_001034659
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  PAGELSLLS 9
          PA  L+LLS
Sbjct: 4  PAARLALLS 12
>NP_001018098
          Length = 3628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GELSLLS 9
           GELSLL+
Sbjct: 223 GELSLLT 229
>NP_060154
          Length = 3710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GELSLLS 9
           GELSLL+
Sbjct: 180 GELSLLT 186
>NP_060550
          Length = 3585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GELSLLS 9
           GELSLL+
Sbjct: 180 GELSLLT 186
>NP_065872
          Length = 3753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GELSLLS 9
           GELSLL+
Sbjct: 223 GELSLLT 229
>NP_001094343
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PA ++SLL+
Sbjct: 284 PAAQISLLT 292
>NP_689550
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PA ++SLL+
Sbjct: 284 PAAQISLLT 292
>NP_055653
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAGELSLLS 9
           P GELS +S
Sbjct: 365 PEGELSSVS 373
>NP_659456
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  PAGELSL 7
          P+GELS+
Sbjct: 68 PSGELSV 74
>NP_001036009
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PAGELSL 7
            P+G+LSL
Sbjct: 1244 PSGDLSL 1250
>NP_001036010
          Length = 1557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PAGELSL 7
            P+G+LSL
Sbjct: 1177 PSGDLSL 1183
>NP_003564
          Length = 1587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    PAGELSL 7
            P+G+LSL
Sbjct: 1207 PSGDLSL 1213
>NP_849193
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PAGELSLLS 9
          PAG  SLLS
Sbjct: 65 PAGWQSLLS 73
>XP_005261932
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   PAGELSLLS 9
           P GELS +S
Sbjct: 365 PEGELSSVS 373
>XP_005255849
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PA ++SLL+
Sbjct: 284 PAAQISLLT 292
>XP_005255848
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   PAGELSLLS 9
           PA ++SLL+
Sbjct: 284 PAAQISLLT 292
>XP_005252630
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 581 PYGEISML 588
>XP_005252629
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 581 PYGEISML 588
>XP_005252628
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 581 PYGEISML 588
>XP_005252627
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 581 PYGEISML 588
>XP_005252626
          Length = 2260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 659 PYGEISML 666
>XP_005252625
          Length = 2277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 659 PYGEISML 666
>XP_005252624
          Length = 2292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 659 PYGEISML 666
>XP_005252623
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 659 PYGEISML 666
>XP_005252622
          Length = 2308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 659 PYGEISML 666
>XP_006717555
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 653 PYGEISML 660
>XP_005252621
          Length = 2334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   PAGELSLL 8
           P GE+S+L
Sbjct: 659 PYGEISML 666
>XP_006713080
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  PAGELSLLS 9
          PAG  SLLS
Sbjct: 65 PAGWQSLLS 73
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.129    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 607,043
Number of extensions: 849
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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