Blast-Search of mutated query peptide against human proteome |
BLASTP 2.2.15 [Oct-15-2006] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= User_input (9 letters) Database: HUMAN_PROTEOME_FASTA 71,491 sequences; 45,948,801 total letters Searching..................................................doneScore E Sequences producing significant alignments: (bits) Value XP_006721912 17 2528 NP_115804 17 3301 XP_006724772 17 3301 XP_005255351 17 3301 XP_005252336 17 3301 NP_001034592 17 3301 NP_002542 17 4312 NP_919310 17 4312 NP_919311 17 4312 NP_919309 17 4312 NP_919313 17 4312 NP_073618 17 4312 NP_060482 17 4312 NP_001092049 17 4312 NP_036505 17 4312 XP_006716784 17 4312 XP_005251425 17 4312 XP_005251424 17 4312 XP_005251423 17 4312 XP_005251422 17 4312 XP_005251421 17 4312 NP_001191355 16 5631 NP_001093320 16 5631 NP_001094101 16 5631 NP_667345 16 5631 NP_002495 16 5631 NP_003300 16 5631 NP_667344 16 5631 NP_001693 16 5631 NP_002305 16 5631 NP_775871 16 5631 XP_006721061 16 5631 XP_006716839 16 5631 XP_005251532 16 5631 XP_005251531 16 5631 XP_005251530 16 5631 XP_005251072 16 5631 XP_006710064 16 5631 NP_001171512 16 7355 NP_001171488 16 7355 NP_001068567 16 7355 NP_003717 16 7355 NP_001156757 16 7355 NP_001156758 16 7355 NP_005234 16 7355 NP_053733 16 7355 NP_058633 16 7355 NP_055030 16 7355 XP_006724562 16 7355 XP_005274609 16 7355 XP_006724230 16 7355 XP_005257813 16 7355 XP_005257814 16 7355 XP_005257812 16 7355 XP_005258114 16 7355 XP_005258113 16 7355 XP_005258112 16 7355 XP_005258111 16 7355 XP_005254804 16 7355 XP_006720791 16 7355 XP_005254803 16 7355 XP_005254800 16 7355 XP_005254799 16 7355 XP_005254051 16 7355 NP_003913 16 7355 NP_110402 15 9605 NP_116031 15 9605 NP_001073336 15 9605 NP_000309 15 9605 NP_689703 15 9605 NP_001264084 15 9605 NP_001165557 15 9605 NP_001165558 15 9605 NP_862827 15 9605 NP_001131140 15 9605 NP_001096637 15 9605 NP_036247 15 9605 NP_001010883 15 9605 NP_001131139 15 9605 XP_006719082 15 9605 XP_005253849 15 9605 XP_006711813 15 9605 XP_005273128 15 9605 XP_006711812 15 9605 NP_612209 15 9605>XP_006721912 Length = 162 Score = 17.3 bits (33), Expect = 2528 Identities = 6/7 (85%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQR Sbjct: 106 PACWTQR 112>NP_115804 Length = 1810 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PACGTQRTA 9 P+CGT+ +A Sbjct: 370 PSCGTKGSA 378>XP_006724772 Length = 1605 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 PACGTQRTA 9 P+CGT+ +A Sbjct: 165 PSCGTKGSA 173>XP_005255351 Length = 370 Score = 16.9 bits (32), Expect = 3301 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 ACGTQRTA 9 ACG+ RTA Sbjct: 89 ACGSLRTA 96>XP_005252336 Length = 227 Score = 16.9 bits (32), Expect = 3301 Identities = 5/9 (55%), Positives = 7/9 (77%) Query: 1 PACGTQRTA 9 PAC + RT+ Sbjct: 187 PACSSSRTS 195>NP_001034592 Length = 553 Score = 16.9 bits (32), Expect = 3301 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 ACGTQRTA 9 ACG+ RTA Sbjct: 295 ACGSLRTA 302>NP_002542 Length = 321 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 6/9 (66%) Query: 1 PACGTQRTA 9 P GT RTA Sbjct: 9 PEAGTNRTA 17>NP_919310 Length = 465 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 169 PACSTQQ 175>NP_919311 Length = 432 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 136 PACSTQQ 142>NP_919309 Length = 432 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 136 PACSTQQ 142>NP_919313 Length = 432 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 136 PACSTQQ 142>NP_073618 Length = 515 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 219 PACSTQQ 225>NP_060482 Length = 2108 Score = 16.5 bits (31), Expect = 4312 Identities = 5/6 (83%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGTQ Sbjct: 633 PICGTQ 638>NP_001092049 Length = 904 Score = 16.5 bits (31), Expect = 4312 Identities = 5/6 (83%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 PACG Q Sbjct: 13 PACGAQ 18>NP_036505 Length = 321 Score = 16.5 bits (31), Expect = 4312 Identities = 6/9 (66%), Positives = 6/9 (66%) Query: 1 PACGTQRTA 9 P GT RTA Sbjct: 9 PEAGTNRTA 17>XP_006716784 Length = 432 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 136 PACSTQQ 142>XP_005251425 Length = 432 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 136 PACSTQQ 142>XP_005251424 Length = 432 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 136 PACSTQQ 142>XP_005251423 Length = 432 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 136 PACSTQQ 142>XP_005251422 Length = 481 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 185 PACSTQQ 191>XP_005251421 Length = 619 Score = 16.5 bits (31), Expect = 4312 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 PACGTQR 7 PAC TQ+ Sbjct: 323 PACSTQQ 329>NP_001191355 Length = 613 Score = 16.2 bits (30), Expect = 5631 Identities = 4/8 (50%), Positives = 6/8 (75%) Query: 1 PACGTQRT 8 P CGT+ + Sbjct: 155 PGCGTEHS 162>NP_001093320 Length = 479 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 5/8 (62%) Query: 1 PACGTQRT 8 P CGT T Sbjct: 458 PCCGTSPT 465>NP_001094101 Length = 481 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 5/8 (62%) Query: 1 PACGTQRT 8 P CGT T Sbjct: 460 PCCGTSPT 467>NP_667345 Length = 833 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 32 CGTQR 36>NP_002495 Length = 1120 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 32 CGTQR 36>NP_003300 Length = 437 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 CGTQRTA 9 CG QR+A Sbjct: 135 CGAQRSA 141>NP_667344 Length = 1024 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 32 CGTQR 36>NP_001693 Length = 1584 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 569 CGTQR 573>NP_002305 Length = 647 Score = 16.2 bits (30), Expect = 5631 Identities = 4/8 (50%), Positives = 6/8 (75%) Query: 1 PACGTQRT 8 P CGT+ + Sbjct: 189 PGCGTEHS 196>NP_775871 Length = 8384 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 716 CGTQR 720>XP_006721061 Length = 688 Score = 16.2 bits (30), Expect = 5631 Identities = 4/6 (66%), Positives = 6/6 (100%) Query: 1 PACGTQ 6 P+CGT+ Sbjct: 35 PSCGTE 40>XP_006716839 Length = 833 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 32 CGTQR 36>XP_005251532 Length = 834 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 32 CGTQR 36>XP_005251531 Length = 1025 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 32 CGTQR 36>XP_005251530 Length = 1121 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 32 CGTQR 36>XP_005251072 Length = 1586 Score = 16.2 bits (30), Expect = 5631 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 3 CGTQR 7 CGTQR Sbjct: 566 CGTQR 570>XP_006710064 Length = 688 Score = 16.2 bits (30), Expect = 5631 Identities = 4/6 (66%), Positives = 6/6 (100%) Query: 1 PACGTQ 6 P+CGT+ Sbjct: 35 PSCGTE 40>NP_001171512 Length = 129 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 CGTQRTA 9 CGT+R A Sbjct: 35 CGTRRIA 41>NP_001171488 Length = 148 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 3 CGTQRTA 9 CGT+R A Sbjct: 54 CGTRRIA 60>NP_001068567 Length = 358 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 6/6 (100%) Query: 1 PACGTQ 6 P+CG+Q Sbjct: 241 PSCGSQ 246>NP_003717 Length = 359 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 6/6 (100%) Query: 1 PACGTQ 6 P+CG+Q Sbjct: 241 PSCGSQ 246>NP_001156757 Length = 655 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 5/9 (55%) Query: 1 PACGTQRTA 9 P CG Q A Sbjct: 526 PGCGNQNFA 534>NP_001156758 Length = 600 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 5/9 (55%) Query: 1 PACGTQRTA 9 P CG Q A Sbjct: 471 PGCGNQNFA 479>NP_005234 Length = 656 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 5/9 (55%) Query: 1 PACGTQRTA 9 P CG Q A Sbjct: 527 PGCGNQNFA 535>NP_053733 Length = 661 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 5/9 (55%) Query: 1 PACGTQRTA 9 P CG Q A Sbjct: 532 PGCGNQNFA 540>NP_058633 Length = 1462 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 1284 PTCGTE 1289>NP_055030 Length = 1297 Score = 15.8 bits (29), Expect = 7355 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 2 ACGTQ 6 ACGTQ Sbjct: 537 ACGTQ 541>XP_006724562 Length = 1326 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 1148 PTCGTE 1153>XP_005274609 Length = 1468 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 1290 PTCGTE 1295>XP_006724230 Length = 639 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 5/9 (55%) Query: 1 PACGTQRTA 9 P CG Q A Sbjct: 527 PGCGNQNFA 535>XP_005257813 Length = 265 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 6/6 (100%) Query: 1 PACGTQ 6 P+CG+Q Sbjct: 147 PSCGSQ 152>XP_005257814 Length = 265 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 6/6 (100%) Query: 1 PACGTQ 6 P+CG+Q Sbjct: 147 PSCGSQ 152>XP_005257812 Length = 341 Score = 15.8 bits (29), Expect = 7355 Identities = 4/6 (66%), Positives = 6/6 (100%) Query: 1 PACGTQ 6 P+CG+Q Sbjct: 241 PSCGSQ 246>XP_005258114 Length = 237 Score = 15.8 bits (29), Expect = 7355 Identities = 5/6 (83%), Positives = 5/6 (83%) Query: 2 ACGTQR 7 ACG QR Sbjct: 12 ACGAQR 17>XP_005258113 Length = 237 Score = 15.8 bits (29), Expect = 7355 Identities = 5/6 (83%), Positives = 5/6 (83%) Query: 2 ACGTQR 7 ACG QR Sbjct: 12 ACGAQR 17>XP_005258112 Length = 238 Score = 15.8 bits (29), Expect = 7355 Identities = 5/6 (83%), Positives = 5/6 (83%) Query: 2 ACGTQR 7 ACG QR Sbjct: 12 ACGAQR 17>XP_005258111 Length = 238 Score = 15.8 bits (29), Expect = 7355 Identities = 5/6 (83%), Positives = 5/6 (83%) Query: 2 ACGTQR 7 ACG QR Sbjct: 12 ACGAQR 17>XP_005254804 Length = 4796 Score = 15.8 bits (29), Expect = 7355 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 2 ACGTQ 6 ACGTQ Sbjct: 4180 ACGTQ 4184>XP_006720791 Length = 4853 Score = 15.8 bits (29), Expect = 7355 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 2 ACGTQ 6 ACGTQ Sbjct: 4237 ACGTQ 4241>XP_005254803 Length = 4854 Score = 15.8 bits (29), Expect = 7355 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 2 ACGTQ 6 ACGTQ Sbjct: 4238 ACGTQ 4242>XP_005254800 Length = 4861 Score = 15.8 bits (29), Expect = 7355 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 2 ACGTQ 6 ACGTQ Sbjct: 4245 ACGTQ 4249>XP_005254799 Length = 4861 Score = 15.8 bits (29), Expect = 7355 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 2 ACGTQ 6 ACGTQ Sbjct: 4245 ACGTQ 4249>XP_005254051 Length = 306 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 6/8 (75%) Query: 2 ACGTQRTA 9 AC TQR + Sbjct: 15 ACATQRAS 22>NP_003913 Length = 4861 Score = 15.8 bits (29), Expect = 7355 Identities = 5/5 (100%), Positives = 5/5 (100%) Query: 2 ACGTQ 6 ACGTQ Sbjct: 4245 ACGTQ 4249>NP_110402 Length = 359 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 5/7 (71%) Query: 3 CGTQRTA 9 CG RTA Sbjct: 141 CGCSRTA 147>NP_116031 Length = 359 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 5/7 (71%) Query: 3 CGTQRTA 9 CG RTA Sbjct: 141 CGCSRTA 147>NP_001073336 Length = 305 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 281 PKCGTE 286>NP_000309 Length = 305 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 281 PKCGTE 286>NP_689703 Length = 500 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P+CG Q Sbjct: 196 PSCGVQ 201>NP_001264084 Length = 326 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P+CG Q Sbjct: 237 PSCGVQ 242>NP_001165557 Length = 305 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 281 PKCGTE 286>NP_001165558 Length = 305 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 281 PKCGTE 286>NP_862827 Length = 480 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 416 PTCGTR 421>NP_001131140 Length = 1982 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 673 PICGTE 678>NP_001096637 Length = 271 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 2 ACGTQRT 8 +C TQRT Sbjct: 208 SCRTQRT 214>NP_036247 Length = 1982 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 673 PICGTE 678>NP_001010883 Length = 360 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 6/8 (75%) Query: 2 ACGTQRTA 9 ACG RT+ Sbjct: 200 ACGHSRTS 207>NP_001131139 Length = 1982 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P CGT+ Sbjct: 673 PICGTE 678>XP_006719082 Length = 400 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 5/7 (71%) Query: 3 CGTQRTA 9 CG RTA Sbjct: 182 CGCSRTA 188>XP_005253849 Length = 411 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 5/7 (71%) Query: 3 CGTQRTA 9 CG RTA Sbjct: 193 CGCSRTA 199>XP_006711813 Length = 225 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P+CG Q Sbjct: 196 PSCGVQ 201>XP_005273128 Length = 291 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P+CG Q Sbjct: 196 PSCGVQ 201>XP_006711812 Length = 586 Score = 15.4 bits (28), Expect = 9605 Identities = 4/6 (66%), Positives = 5/6 (83%) Query: 1 PACGTQ 6 P+CG Q Sbjct: 196 PSCGVQ 201>NP_612209 Length = 252 Score = 15.4 bits (28), Expect = 9605 Identities = 4/7 (57%), Positives = 5/7 (71%) Query: 1 PACGTQR 7 P CGT + Sbjct: 164 PLCGTNK 170Database: HUMAN_PROTEOME_FASTA Posted date: May 26, 2014 10:46 AM Number of letters in database: 45,948,801 Number of sequences in database: 71,491 Lambda K H 0.318 0.124 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 71491 Number of Hits to DB: 609,236 Number of extensions: 976 Number of successful extensions: 85 Number of sequences better than 10000.0: 85 Number of HSP's gapped: 85 Number of HSP's successfully gapped: 85 Length of query: 9 Length of database: 45,948,801 Length adjustment: 0 Effective length of query: 9 Effective length of database: 45,948,801 Effective search space: 413539209 Effective search space used: 413539209 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 28 (15.8 bits) S2: 28 (15.4 bits)
|
CANCERTOPE | Raghava's Group | IMTECH | CSIR | CRDD | GPSR Package |