Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              21     175
NP_000757                                                              18    1935
NP_000753                                                              18    1935
NP_001138                                                              18    1935
NP_001112359                                                           18    1935
NP_694987                                                              17    3301
NP_060166                                                              17    3301
NP_055928                                                              17    4312
NP_001186308                                                           17    4312
NP_001186307                                                           17    4312
NP_006257                                                              17    4312
NP_001035827                                                           17    4312
NP_001258705                                                           17    4312
NP_001258704                                                           17    4312
NP_001258703                                                           17    4312
NP_004184                                                              17    4312
XP_005261542                                                           17    4312
XP_005256618                                                           17    4312
XP_005256617                                                           17    4312
XP_006718114                                                           17    4312
XP_005270318                                                           17    4312
XP_006718113                                                           17    4312
XP_006718112                                                           17    4312
XP_006718111                                                           17    4312
XP_006718110                                                           17    4312
NP_777592                                                              17    4312
NP_443120                                                              16    5631
NP_570969                                                              16    7355
NP_031363                                                              16    7355
NP_031361                                                              16    7355
NP_085079                                                              16    7355
NP_000755                                                              16    7355
NP_060024                                                              16    7355
NP_056535                                                              16    7355
XP_005247602                                                           16    7355
XP_006713504                                                           16    7355
XP_006713503                                                           16    7355
XP_005265688                                                           16    7355
XP_006713502                                                           16    7355
XP_006713501                                                           16    7355
XP_006713500                                                           16    7355
XP_005265687                                                           16    7355
XP_005273394                                                           16    7355
NP_076985                                                              15    9605
NP_057710                                                              15    9605
NP_002053                                                              15    9605
NP_003373                                                              15    9605
NP_775808                                                              15    9605
XP_005255411                                                           15    9605
XP_006721113                                                           15    9605
XP_005277669                                                           15    9605
XP_006716171                                                           15    9605
XP_006716170                                                           15    9605
XP_005249618                                                           15    9605
XP_005277638                                                           15    9605
XP_005277637                                                           15    9605
XP_005277636                                                           15    9605
XP_006715128                                                           15    9605
NP_001027563                                                           15    9605
NP_057393                                                              15    9605
NP_001003795                                                           15    9605
>NP_004251
          Length = 1208

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NYVQLNMKQ 9
           NYV+LNMKQ
Sbjct: 352 NYVRLNMKQ 360
>NP_000757
          Length = 494

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  NYVQLNMKQ 9
          NY+QLN +Q
Sbjct: 45 NYLQLNTEQ 53
>NP_000753
          Length = 494

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  NYVQLNMKQ 9
          NY+QLN +Q
Sbjct: 45 NYLQLNTEQ 53
>NP_001138
          Length = 496

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+Q NMK+
Sbjct: 99  NYIQDNMKK 107
>NP_001112359
          Length = 495

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+Q NMK+
Sbjct: 99  NYIQDNMKK 107
>NP_694987
          Length = 391

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+Q+N +Q
Sbjct: 266 NYIQVNNEQ 274
>NP_060166
          Length = 1143

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+Q+N +Q
Sbjct: 266 NYIQVNNEQ 274
>NP_055928
          Length = 2961

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YVQLNMKQ 9
           YVQ+N+K+
Sbjct: 356 YVQINIKR 363
>NP_001186308
          Length = 1855

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>NP_001186307
          Length = 1856

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>NP_006257
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YVQLNM 7
           YVQLNM
Sbjct: 227 YVQLNM 232
>NP_001035827
          Length = 859

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YVQLNM 7
           YVQLNM
Sbjct: 172 YVQLNM 177
>NP_001258705
          Length = 902

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YVQLNM 7
           YVQLNM
Sbjct: 215 YVQLNM 220
>NP_001258704
          Length = 913

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YVQLNM 7
           YVQLNM
Sbjct: 226 YVQLNM 231
>NP_001258703
          Length = 885

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YVQLNM 7
           YVQLNM
Sbjct: 198 YVQLNM 203
>NP_004184
          Length = 1859

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>XP_005261542
          Length = 264

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  NYVQLNMK 8
          NY+ LN+K
Sbjct: 56 NYLDLNLK 63
>XP_005256618
          Length = 2962

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YVQLNMKQ 9
           YVQ+N+K+
Sbjct: 356 YVQINIKR 363
>XP_005256617
          Length = 2966

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YVQLNMKQ 9
           YVQ+N+K+
Sbjct: 356 YVQINIKR 363
>XP_006718114
          Length = 1850

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>XP_005270318
          Length = 1860

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>XP_006718113
          Length = 1881

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>XP_006718112
          Length = 1889

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>XP_006718111
          Length = 1892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>XP_006718110
          Length = 1893

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NYV  NMK+
Sbjct: 205 NYVGTNMKK 213
>NP_777592
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NYVQLNMK 8
           NY+ LN+K
Sbjct: 242 NYLDLNLK 249
>NP_443120
          Length = 947

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NY+  NM+Q
Sbjct: 874 NYINENMEQ 882
>NP_570969
          Length = 605

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  NYVQLNMK 8
          N++Q+N K
Sbjct: 50 NFIQINKK 57
>NP_031363
          Length = 1778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 769 NYIGINVKK 777
>NP_031361
          Length = 1755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 769 NYIGINVKK 777
>NP_085079
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  NYVQLN 6
          NY+QLN
Sbjct: 45 NYLQLN 50
>NP_000755
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  NYVQLN 6
          NY+QLN
Sbjct: 45 NYLQLN 50
>NP_060024
          Length = 1801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NYVQLNMK 8
           N+V+ NMK
Sbjct: 663 NFVEQNMK 670
>NP_056535
          Length = 605

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NYVQLNMKQ 9
           NY+ LNM +
Sbjct: 390 NYIILNMTE 398
>XP_005247602
          Length = 1665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NYVQLNMK 8
           N+V+ NMK
Sbjct: 527 NFVEQNMK 534
>XP_006713504
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  NYVQLNMKQ 9
          NY+ +N+K+
Sbjct: 66 NYIGINVKK 74
>XP_006713503
          Length = 1438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 769 NYIGINVKK 777
>XP_005265688
          Length = 1480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 468 NYIGINVKK 476
>XP_006713502
          Length = 1578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 769 NYIGINVKK 777
>XP_006713501
          Length = 1727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 769 NYIGINVKK 777
>XP_006713500
          Length = 1746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 769 NYIGINVKK 777
>XP_005265687
          Length = 1758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY+ +N+K+
Sbjct: 769 NYIGINVKK 777
>XP_005273394
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NYVQLNMKQ 9
           NY++ NM++
Sbjct: 403 NYIEKNMER 411
>NP_076985
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  NYVQLNMKQ 9
          N++Q N K+
Sbjct: 43 NFIQANFKK 51
>NP_057710
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   NYVQLN 6
           NY++LN
Sbjct: 397 NYIELN 402
>NP_002053
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY+ LN+
Sbjct: 177 NYIHLNL 183
>NP_003373
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY+ LN+
Sbjct: 159 NYIHLNL 165
>NP_775808
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYVQLNMK 8
           NY Q NM+
Sbjct: 242 NYYQYNMQ 249
>XP_005255411
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY Q+NM
Sbjct: 127 NYEQVNM 133
>XP_006721113
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY Q+NM
Sbjct: 204 NYEQVNM 210
>XP_005277669
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYVQLNMK 8
           NY Q NM+
Sbjct: 242 NYYQYNMQ 249
>XP_006716171
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY+ LN+
Sbjct: 96  NYIHLNL 102
>XP_006716170
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY+ LN+
Sbjct: 159 NYIHLNL 165
>XP_005249618
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY+ LN+
Sbjct: 184 NYIHLNL 190
>XP_005277638
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  NYVQLNMK 8
          NY Q NM+
Sbjct: 48 NYYQYNMQ 55
>XP_005277637
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYVQLNMK 8
           NY Q NM+
Sbjct: 171 NYYQYNMQ 178
>XP_005277636
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYVQLNMK 8
           NY Q NM+
Sbjct: 242 NYYQYNMQ 249
>XP_006715128
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY+ LN+
Sbjct: 177 NYIHLNL 183
>NP_001027563
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY Q+NM
Sbjct: 172 NYEQVNM 178
>NP_057393
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYVQLNM 7
           NY Q+NM
Sbjct: 227 NYEQVNM 233
>NP_001003795
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NYVQLNMK 8
           NY Q NM+
Sbjct: 242 NYYQYNMQ 249
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.125    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 391,267
Number of extensions: 731
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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