Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     299
NP_001075109                                                           20     299
NP_112180                                                              18    1482
XP_005245569                                                           18    1482
XP_005245568                                                           18    1482
XP_005245567                                                           18    1482
XP_005245566                                                           18    1482
NP_000520                                                              17    3301
NP_005126                                                              17    4312
NP_598408                                                              17    4312
NP_001035959                                                           17    4312
NP_001035962                                                           17    4312
NP_001035960                                                           17    4312
NP_001035961                                                           17    4312
NP_056045                                                              17    4312
NP_065759                                                              17    4312
NP_001128243                                                           17    4312
NP_001139433                                                           17    4312
NP_005063                                                              17    4312
NP_001139436                                                           17    4312
NP_001139435                                                           17    4312
NP_001139434                                                           17    4312
NP_055698                                                              17    4312
NP_006589                                                              17    4312
XP_006725069                                                           17    4312
XP_006720856                                                           17    4312
XP_005248288                                                           17    4312
XP_005262742                                                           17    4312
XP_005262741                                                           17    4312
XP_006714120                                                           17    4312
XP_005262740                                                           17    4312
XP_005262739                                                           17    4312
XP_005262738                                                           17    4312
XP_005262700                                                           17    4312
XP_005262697                                                           17    4312
XP_006714054                                                           17    4312
XP_005262695                                                           17    4312
XP_005276150                                                           17    4312
NP_001186020                                                           16    5631
NP_001186014                                                           16    5631
NP_775804                                                              16    5631
NP_001186018                                                           16    5631
NP_569733                                                              16    5631
NP_904324                                                              16    5631
XP_006719745                                                           16    5631
XP_006719744                                                           16    5631
XP_005254044                                                           16    5631
XP_005244992                                                           16    5631
XP_006711258                                                           16    5631
XP_005244991                                                           16    5631
NP_443099                                                              16    7355
NP_001231888                                                           16    7355
NP_777598                                                              16    7355
NP_001231889                                                           16    7355
NP_036477                                                              16    7355
NP_775922                                                              16    7355
XP_005254432                                                           16    7355
XP_006720008                                                           16    7355
XP_006720007                                                           16    7355
XP_006720006                                                           16    7355
XP_005251939                                                           16    7355
NP_004611                                                              15    9605
NP_665802                                                              15    9605
>NP_008835
          Length = 4128

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NYMSLFEVL 9
           NY+SLFEVL
Sbjct: 289 NYVSLFEVL 297
>NP_001075109
          Length = 4097

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NYMSLFEVL 9
           NY+SLFEVL
Sbjct: 289 NYVSLFEVL 297
>NP_112180
          Length = 528

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NYMSLFEVL 9
           NY +LFEV+
Sbjct: 316 NYFALFEVI 324
>XP_005245569
          Length = 355

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NYMSLFEVL 9
           NY +LFEV+
Sbjct: 130 NYFALFEVI 138
>XP_005245568
          Length = 342

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NYMSLFEVL 9
           NY +LFEV+
Sbjct: 130 NYFALFEVI 138
>XP_005245567
          Length = 438

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NYMSLFEVL 9
           NY +LFEV+
Sbjct: 213 NYFALFEVI 221
>XP_005245566
          Length = 541

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NYMSLFEVL 9
           NY +LFEV+
Sbjct: 316 NYFALFEVI 324
>NP_000520
          Length = 297

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YMSLFEV 8
           YMSLF+V
Sbjct: 254 YMSLFQV 260
>NP_005126
          Length = 1099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1069 NYMEFLEVL 1077
>NP_598408
          Length = 1150

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1120 NYMEFLEVL 1128
>NP_001035959
          Length = 1091

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1061 NYMEFLEVL 1069
>NP_001035962
          Length = 1135

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1105 NYMEFLEVL 1113
>NP_001035960
          Length = 1091

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1061 NYMEFLEVL 1069
>NP_001035961
          Length = 1141

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1111 NYMEFLEVL 1119
>NP_056045
          Length = 1704

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NYMSLFEV 8
            NY+ +FEV
Sbjct: 1292 NYVEIFEV 1299
>NP_065759
          Length = 1116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1086 NYMEFLEVL 1094
>NP_001128243
          Length = 1139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1109 NYMEFLEVL 1117
>NP_001139433
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1049 NYMEFLEVL 1057
>NP_005063
          Length = 1085

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1055 NYMEFLEVL 1063
>NP_001139436
          Length = 1054

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1024 NYMEFLEVL 1032
>NP_001139435
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1049 NYMEFLEVL 1057
>NP_001139434
          Length = 1087

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1057 NYMEFLEVL 1065
>NP_055698
          Length = 1023

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY +LFEV
Sbjct: 226 NYNTLFEV 233
>NP_006589
          Length = 1083

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1053 NYMEFLEVL 1061
>XP_006725069
          Length = 1088

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1058 NYMEFLEVL 1066
>XP_006720856
          Length = 1101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1071 NYMEFLEVL 1079
>XP_005248288
          Length = 1088

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NYMSLFEVL 9
            NYM   EVL
Sbjct: 1058 NYMEFLEVL 1066
>XP_005262742
          Length = 584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY +LFEV
Sbjct: 226 NYNTLFEV 233
>XP_005262741
          Length = 814

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NYMSLFEV 8
          NY +LFEV
Sbjct: 17 NYNTLFEV 24
>XP_006714120
          Length = 834

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NYMSLFEV 8
          NY +LFEV
Sbjct: 37 NYNTLFEV 44
>XP_005262740
          Length = 995

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY +LFEV
Sbjct: 226 NYNTLFEV 233
>XP_005262739
          Length = 1003

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY +LFEV
Sbjct: 206 NYNTLFEV 213
>XP_005262738
          Length = 1009

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY +LFEV
Sbjct: 226 NYNTLFEV 233
>XP_005262700
          Length = 907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY+ +FEV
Sbjct: 495 NYVEIFEV 502
>XP_005262697
          Length = 1681

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NYMSLFEV 8
            NY+ +FEV
Sbjct: 1292 NYVEIFEV 1299
>XP_006714054
          Length = 1693

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NYMSLFEV 8
            NY+ +FEV
Sbjct: 1281 NYVEIFEV 1288
>XP_005262695
          Length = 1704

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NYMSLFEV 8
            NY+ +FEV
Sbjct: 1292 NYVEIFEV 1299
>XP_005276150
          Length = 156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYMSLFEVL 9
           NY++L EV+
Sbjct: 148 NYLALLEVM 156
>NP_001186020
          Length = 981

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_001186014
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_775804
          Length = 981

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_001186018
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_569733
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYMSLFE 7
           NY+ LFE
Sbjct: 770 NYLQLFE 776
>NP_904324
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYMSLFE 7
           NY+ LFE
Sbjct: 770 NYLQLFE 776
>XP_006719745
          Length = 1043

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYMSLFE 7
           NY+ LFE
Sbjct: 770 NYLQLFE 776
>XP_006719744
          Length = 1044

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYMSLFE 7
           NY+ LFE
Sbjct: 770 NYLQLFE 776
>XP_005254044
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYMSLFE 7
           NY+ LFE
Sbjct: 770 NYLQLFE 776
>XP_005244992
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>XP_006711258
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>XP_005244991
          Length = 1035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           ++S+FEVL
Sbjct: 172 FLSMFEVL 179
>NP_443099
          Length = 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           +MS+F++L
Sbjct: 544 FMSMFQIL 551
>NP_001231888
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY+S FE+
Sbjct: 171 NYISEFEI 178
>NP_777598
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY+S FE+
Sbjct: 171 NYISEFEI 178
>NP_001231889
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NYMSLFEV 8
           NY+S FE+
Sbjct: 127 NYISEFEI 134
>NP_036477
          Length = 495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NYMSLFE 7
           NY +LFE
Sbjct: 440 NYQTLFE 446
>NP_775922
          Length = 6996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YMSLFEV 8
            Y+SLF+V
Sbjct: 1321 YLSLFDV 1327
>XP_005254432
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  NYMSLFEVL 9
          NYM   EVL
Sbjct: 12 NYMGCVEVL 20
>XP_006720008
          Length = 1645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           +MS+F++L
Sbjct: 544 FMSMFQIL 551
>XP_006720007
          Length = 1709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           +MS+F++L
Sbjct: 515 FMSMFQIL 522
>XP_006720006
          Length = 1713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YMSLFEVL 9
           +MS+F++L
Sbjct: 544 FMSMFQIL 551
>XP_005251939
          Length = 501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  NYMSLFEV 8
          NY+S FE+
Sbjct: 75 NYISEFEI 82
>NP_004611
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMSLF 6
           NY+SLF
Sbjct: 405 NYISLF 410
>NP_665802
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMSLF 6
           NY+SLF
Sbjct: 405 NYISLF 410
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.143    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 344,262
Number of extensions: 581
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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