Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              20     390
NP_060626                                                              18    1935
NP_056193                                                              18    1935
NP_001136069                                                           17    2528
NP_001180584                                                           16    5631
NP_001180586                                                           16    5631
NP_001180583                                                           16    5631
NP_001093877                                                           16    5631
NP_001180582                                                           16    5631
NP_001028218                                                           16    5631
NP_001093878                                                           16    5631
XP_006722356                                                           16    5631
NP_001006658                                                           16    7355
NP_065830                                                              16    7355
NP_001107604                                                           15    9605
XP_005253558                                                           15    9605
XP_006719219                                                           15    9605
XP_005253556                                                           15    9605
XP_005253555                                                           15    9605
XP_006712765                                                           15    9605
XP_006712764                                                           15    9605
XP_005246844                                                           15    9605
XP_006712763                                                           15    9605
XP_006712762                                                           15    9605
XP_006712761                                                           15    9605
>NP_055365
          Length = 1032

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NYMITMRLA 9
           NYMI MRLA
Sbjct: 206 NYMIAMRLA 214
>NP_060626
          Length = 4363

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NYMITMRL 8
            NYM+ MRL
Sbjct: 3222 NYMVRMRL 3229
>NP_056193
          Length = 4388

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NYMITMRL 8
            NYM+ MRL
Sbjct: 3247 NYMVRMRL 3254
>NP_001136069
          Length = 361

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NYMITMRLA 9
           NY IT RLA
Sbjct: 136 NYAITSRLA 144
>NP_001180584
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 124 YMVVLRLA 131
>NP_001180586
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 124 YMVVLRLA 131
>NP_001180583
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 124 YMVVLRLA 131
>NP_001093877
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 124 YMVVLRLA 131
>NP_001180582
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 124 YMVVLRLA 131
>NP_001028218
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 124 YMVVLRLA 131
>NP_001093878
          Length = 173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 110 YMVVLRLA 117
>XP_006722356
          Length = 173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YMITMRLA 9
           YM+ +RLA
Sbjct: 110 YMVVLRLA 117
>NP_001006658
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYMITMRLA 9
           N+MI M+L+
Sbjct: 188 NFMIKMKLS 196
>NP_065830
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NYMITMRLA 9
           N+MI M+L+
Sbjct: 188 NFMIKMKLS 196
>NP_001107604
          Length = 2694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMITM 6
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_005253558
          Length = 897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NYMITMR 7
           N+++TMR
Sbjct: 253 NFLLTMR 259
>XP_006719219
          Length = 910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NYMITMR 7
           N+++TMR
Sbjct: 322 NFLLTMR 328
>XP_005253556
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NYMITMR 7
           N+++TMR
Sbjct: 322 NFLLTMR 328
>XP_005253555
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NYMITMR 7
           N+++TMR
Sbjct: 322 NFLLTMR 328
>XP_006712765
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMITM 6
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712764
          Length = 2697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMITM 6
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_005246844
          Length = 2707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMITM 6
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712763
          Length = 2716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMITM 6
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712762
          Length = 2723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMITM 6
           NY+ITM
Sbjct: 117 NYVITM 122
>XP_006712761
          Length = 2736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NYMITM 6
           NY+ITM
Sbjct: 117 NYVITM 122
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.137    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 269,310
Number of extensions: 286
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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