Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064615                                                              18    1935
NP_001185619                                                           18    1935
NP_001035754                                                           18    1935
NP_751951                                                              17    3301
NP_058640                                                              17    3301
NP_001167594                                                           17    3301
XP_006722587                                                           17    3301
NP_599030                                                              16    5631
NP_001167597                                                           16    5631
NP_036438                                                              16    5631
NP_001167601                                                           16    5631
NP_001167596                                                           16    5631
NP_001167600                                                           16    5631
NP_037477                                                              16    5631
NP_001265623                                                           16    5631
NP_000608                                                              16    5631
NP_001167599                                                           16    5631
NP_001167598                                                           16    5631
NP_001265624                                                           16    5631
XP_005257062                                                           16    5631
XP_005268973                                                           16    5631
XP_005268971                                                           16    5631
XP_005268970                                                           16    5631
XP_005268969                                                           16    5631
XP_005268968                                                           16    5631
XP_005268787                                                           16    5631
NP_057197                                                              16    7355
NP_848622                                                              16    7355
NP_001229725                                                           16    7355
NP_001229724                                                           16    7355
NP_055484                                                              16    7355
XP_005256735                                                           16    7355
XP_005256734                                                           16    7355
XP_006721606                                                           16    7355
XP_006721605                                                           16    7355
XP_006721604                                                           16    7355
XP_005256733                                                           16    7355
XP_005256320                                                           16    7355
NP_056289                                                              15    9605
NP_056998                                                              15    9605
NP_055486                                                              15    9605
NP_002214                                                              15    9605
XP_005260441                                                           15    9605
XP_006719127                                                           15    9605
XP_005249622                                                           15    9605
XP_005249621                                                           15    9605
XP_006715729                                                           15    9605
XP_006715728                                                           15    9605
XP_006715727                                                           15    9605
XP_006715726                                                           15    9605
NP_872352                                                              15    9605
NP_795362                                                              15    9605
NP_795363                                                              15    9605
>NP_064615
          Length = 473

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           NVYFK++ L
Sbjct: 94  NVYFKLMRL 102
>NP_001185619
          Length = 520

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           NVYFK++ L
Sbjct: 94  NVYFKLMRL 102
>NP_001035754
          Length = 794

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           NVYFK++ L
Sbjct: 94  NVYFKLMRL 102
>NP_751951
          Length = 123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NVYFKILYL 9
          N Y+ ILYL
Sbjct: 45 NFYYVILYL 53
>NP_058640
          Length = 299

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VYFKILYL 9
           VYF ILY+
Sbjct: 233 VYFLILYI 240
>NP_001167594
          Length = 685

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVYFKIL 7
           N+YFK+L
Sbjct: 253 NIYFKML 259
>XP_006722587
          Length = 685

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVYFKIL 7
           N+YFK+L
Sbjct: 253 NIYFKML 259
>NP_599030
          Length = 190

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VYFKIL 7
           VYFKIL
Sbjct: 122 VYFKIL 127
>NP_001167597
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 491 NMYFVVVYV 499
>NP_036438
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N+Y  I+Y+
Sbjct: 295 NIYLDIIYI 303
>NP_001167601
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 487 NMYFVVVYV 495
>NP_001167596
          Length = 590

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 520 NMYFVVVYV 528
>NP_001167600
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 491 NMYFVVVYV 499
>NP_037477
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N+Y  IL+L
Sbjct: 125 NIYVSILFL 133
>NP_001265623
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N+Y  IL+L
Sbjct: 125 NIYVSILFL 133
>NP_000608
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 491 NMYFVVVYV 499
>NP_001167599
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 491 NMYFVVVYV 499
>NP_001167598
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 491 NMYFVVVYV 499
>NP_001265624
          Length = 371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N+Y  IL+L
Sbjct: 116 NIYVSILFL 124
>XP_005257062
          Length = 202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VYFKIL 7
           VYFKIL
Sbjct: 122 VYFKIL 127
>XP_005268973
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 412 NMYFVVVYV 420
>XP_005268971
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 454 NMYFVVVYV 462
>XP_005268970
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 454 NMYFVVVYV 462
>XP_005268969
          Length = 564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 487 NMYFVVVYV 495
>XP_005268968
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NVYFKILYL 9
           N+YF ++Y+
Sbjct: 520 NMYFVVVYV 528
>XP_005268787
          Length = 274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N+Y  I+Y+
Sbjct: 253 NIYLDIIYI 261
>NP_057197
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YFKILYL 9
           YF+IL+L
Sbjct: 469 YFEILFL 475
>NP_848622
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NVYFKILYL 9
           N YF  LY+
Sbjct: 644 NYYFMFLYV 652
>NP_001229725
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VYFKILYL 9
           +YF++L+L
Sbjct: 338 LYFQVLFL 345
>NP_001229724
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VYFKILYL 9
           +YF++L+L
Sbjct: 338 LYFQVLFL 345
>NP_055484
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VYFKILYL 9
           +YF++L+L
Sbjct: 461 LYFQVLFL 468
>XP_005256735
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YFKILYL 9
           YF+IL+L
Sbjct: 469 YFEILFL 475
>XP_005256734
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YFKILYL 9
           YF+IL+L
Sbjct: 469 YFEILFL 475
>XP_006721606
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YFKILYL 9
           YF+IL+L
Sbjct: 469 YFEILFL 475
>XP_006721605
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YFKILYL 9
           YF+IL+L
Sbjct: 469 YFEILFL 475
>XP_006721604
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YFKILYL 9
           YF+IL+L
Sbjct: 469 YFEILFL 475
>XP_005256733
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YFKILYL 9
           YF+IL+L
Sbjct: 468 YFEILFL 474
>XP_005256320
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VYFKILYL 9
           +YF++L+L
Sbjct: 461 LYFQVLFL 468
>NP_056289
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NVYFKILY 8
           N++ +ILY
Sbjct: 425 NIFLEILY 432
>NP_056998
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YFKILYL 9
           YF ++YL
Sbjct: 180 YFPVIYL 186
>NP_055486
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N Y++ LYL
Sbjct: 205 NGYYRSLYL 213
>NP_002214
          Length = 2701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    YFKILY 8
            +FK+LY
Sbjct: 1806 FFKVLY 1811
>XP_005260441
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NVYFKILY 8
           N++ +ILY
Sbjct: 425 NIFLEILY 432
>XP_006719127
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    YFKILY 8
            +FK+LY
Sbjct: 1806 FFKVLY 1811
>XP_005249622
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N Y++ LYL
Sbjct: 205 NGYYRSLYL 213
>XP_005249621
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVYFKILYL 9
           N Y++ LYL
Sbjct: 180 NGYYRSLYL 188
>XP_006715729
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VYFKILYL 9
          V+F +LY+
Sbjct: 12 VFFSVLYV 19
>XP_006715728
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VYFKILYL 9
          V+F +LY+
Sbjct: 12 VFFSVLYV 19
>XP_006715727
          Length = 240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VYFKILYL 9
          V+F +LY+
Sbjct: 12 VFFSVLYV 19
>XP_006715726
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VYFKILYL 9
          V+F +LY+
Sbjct: 12 VFFSVLYV 19
>NP_872352
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VYFKILYL 9
          V+F +LY+
Sbjct: 12 VFFSVLYV 19
>NP_795362
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YFKILYL 9
           YF ILY+
Sbjct: 266 YFLILYI 272
>NP_795363
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YFKILYL 9
           YF ILY+
Sbjct: 251 YFLILYI 257
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.162    0.493 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 488,362
Number of extensions: 973
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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