Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              21     175
XP_005271924                                                           21     175
XP_005271923                                                           21     175
NP_065861                                                              18    1482
XP_005267973                                                           18    1482
NP_112211                                                              17    2528
XP_005267209                                                           17    2528
NP_000072                                                              16    5631
XP_006711794                                                           16    5631
XP_005273086                                                           16    5631
XP_005273085                                                           16    5631
XP_005273084                                                           16    5631
NP_525023                                                              16    7355
XP_006721856                                                           16    7355
XP_006721855                                                           16    7355
XP_006721854                                                           16    7355
XP_006721853                                                           16    7355
XP_005248127                                                           16    7355
XP_005248126                                                           16    7355
XP_005248125                                                           16    7355
XP_005248124                                                           16    7355
XP_005248123                                                           16    7355
XP_005248122                                                           16    7355
XP_005248121                                                           16    7355
XP_005248120                                                           16    7355
XP_006714059                                                           16    7355
XP_005248119                                                           16    7355
XP_005248118                                                           16    7355
XP_005248117                                                           16    7355
XP_005248116                                                           16    7355
XP_005248115                                                           16    7355
XP_005248114                                                           16    7355
NP_619634                                                              16    7355
NP_002462                                                              15    9605
NP_031399                                                              15    9605
NP_115495                                                              15    9605
NP_000248                                                              15    9605
NP_055928                                                              15    9605
NP_065816                                                              15    9605
NP_001255968                                                           15    9605
NP_001191676                                                           15    9605
NP_002904                                                              15    9605
NP_001264198                                                           15    9605
NP_036553                                                              15    9605
XP_005256618                                                           15    9605
XP_005256617                                                           15    9605
XP_005267753                                                           15    9605
XP_006720215                                                           15    9605
XP_006720214                                                           15    9605
XP_005267751                                                           15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605
NP_001005514                                                           15    9605
NP_001004759                                                           15    9605
>NP_001261
          Length = 1710

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NVRGMRKLD 9
           NVRGM+KLD
Sbjct: 342 NVRGMKKLD 350
>XP_005271924
          Length = 1710

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NVRGMRKLD 9
           NVRGM+KLD
Sbjct: 342 NVRGMKKLD 350
>XP_005271923
          Length = 1798

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NVRGMRKLD 9
           NVRGM+KLD
Sbjct: 342 NVRGMKKLD 350
>NP_065861
          Length = 509

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  NVRGMRKLD 9
          +VRGM KLD
Sbjct: 78 DVRGMTKLD 86
>XP_005267973
          Length = 537

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NVRGMRKLD 9
           +VRGM KLD
Sbjct: 106 DVRGMTKLD 114
>NP_112211
          Length = 165

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRGMRKL 8
           +RGMRKL
Sbjct: 151 IRGMRKL 157
>XP_005267209
          Length = 108

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRGMRKL 8
           +RGMRKL
Sbjct: 94  IRGMRKL 100
>NP_000072
          Length = 3801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NVRGMRKLD 9
            ++RGM K+D
Sbjct: 2908 HIRGMYKVD 2916
>XP_006711794
          Length = 3022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NVRGMRKLD 9
            ++RGM K+D
Sbjct: 2129 HIRGMYKVD 2137
>XP_005273086
          Length = 3264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NVRGMRKLD 9
            ++RGM K+D
Sbjct: 2908 HIRGMYKVD 2916
>XP_005273085
          Length = 3755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NVRGMRKLD 9
            ++RGM K+D
Sbjct: 2862 HIRGMYKVD 2870
>XP_005273084
          Length = 3801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NVRGMRKLD 9
            ++RGM K+D
Sbjct: 2908 HIRGMYKVD 2916
>NP_525023
          Length = 1617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRGMRKLD 9
            V+G+RK D
Sbjct: 1381 VKGLRKAD 1388
>XP_006721856
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRGMRKLD 9
            V+G+RK D
Sbjct: 1064 VKGLRKAD 1071
>XP_006721855
          Length = 1551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRGMRKLD 9
            V+G+RK D
Sbjct: 1315 VKGLRKAD 1322
>XP_006721854
          Length = 1577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRGMRKLD 9
            V+G+RK D
Sbjct: 1341 VKGLRKAD 1348
>XP_006721853
          Length = 1617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRGMRKLD 9
            V+G+RK D
Sbjct: 1381 VKGLRKAD 1388
>XP_005248127
          Length = 1322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>XP_005248126
          Length = 1359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 528 LKGQRKLD 535
>XP_005248125
          Length = 1439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 608 LKGQRKLD 615
>XP_005248124
          Length = 1467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 640 LKGQRKLD 647
>XP_005248123
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 640 LKGQRKLD 647
>XP_005248122
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 640 LKGQRKLD 647
>XP_005248121
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 712 LKGQRKLD 719
>XP_005248120
          Length = 1549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 718 LKGQRKLD 725
>XP_006714059
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>XP_005248119
          Length = 1601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>XP_005248118
          Length = 1602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>XP_005248117
          Length = 1626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>XP_005248116
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>XP_005248115
          Length = 1629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>XP_005248114
          Length = 1630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRGMRKLD 9
           ++G RKLD
Sbjct: 799 LKGQRKLD 806
>NP_619634
          Length = 147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRGMRKL 8
           +RGM+KL
Sbjct: 135 IRGMQKL 141
>NP_002462
          Length = 1939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NVRGMRK 7
            +V+GMRK
Sbjct: 1838 SVKGMRK 1844
>NP_031399
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVRGMRKLD 9
           N+R +R+LD
Sbjct: 446 NLRKLRELD 454
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VRGMRKLD 9
            +RG++K D
Sbjct: 5099 IRGLQKFD 5106
>NP_000248
          Length = 1935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NVRGMRK 7
            +V+GMRK
Sbjct: 1836 SVKGMRK 1842
>NP_055928
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    GMRKLD 9
            G+RKLD
Sbjct: 1075 GLRKLD 1080
>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3236 HVRGIKKL 3243
>NP_001255968
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVRGMRKLD 9
           N+R +R+LD
Sbjct: 400 NLRKLRELD 408
>NP_001191676
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVRGMRKL 8
           NV+G RK+
Sbjct: 510 NVQGKRKI 517
>NP_002904
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVRGMRKL 8
           NV+G RK+
Sbjct: 510 NVQGKRKI 517
>NP_001264198
          Length = 2925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  NVRGMR 6
          NV+GMR
Sbjct: 48 NVKGMR 53
>NP_036553
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NVRGMRK 7
           N RGM+K
Sbjct: 967 NARGMQK 973
>XP_005256618
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    GMRKLD 9
            G+RKLD
Sbjct: 1076 GLRKLD 1081
>XP_005256617
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    GMRKLD 9
            G+RKLD
Sbjct: 1076 GLRKLD 1081
>XP_005267753
          Length = 1935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NVRGMRK 7
            +V+GMRK
Sbjct: 1836 SVKGMRK 1842
>XP_006720215
          Length = 1968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NVRGMRK 7
            +V+GMRK
Sbjct: 1867 SVKGMRK 1873
>XP_006720214
          Length = 1978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NVRGMRK 7
            +V+GMRK
Sbjct: 1877 SVKGMRK 1883
>XP_005267751
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NVRGMRK 7
            +V+GMRK
Sbjct: 1878 SVKGMRK 1884
>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3230 HVRGIKKL 3237
>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3241 HVRGIKKL 3248
>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3247 HVRGIKKL 3254
>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3248 HVRGIKKL 3255
>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3265 HVRGIKKL 3272
>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3274 HVRGIKKL 3281
>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3275 HVRGIKKL 3282
>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3275 HVRGIKKL 3282
>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NVRGMRKL 8
            +VRG++KL
Sbjct: 3276 HVRGIKKL 3283
>NP_001005514
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVRGMRK 7
           +V+GMRK
Sbjct: 230 SVKGMRK 236
>NP_001004759
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVRGMR 6
           NVRG+R
Sbjct: 345 NVRGLR 350
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.143    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,142
Number of extensions: 632
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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