Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              17    2528
XP_006722198                                                           17    2528
XP_005257783                                                           17    2528
XP_005257782                                                           17    2528
XP_006722197                                                           17    2528
XP_006722196                                                           17    2528
NP_115509                                                              17    2528
NP_002086                                                              17    4312
NP_001129631                                                           17    4312
NP_001129630                                                           17    4312
NP_001129629                                                           17    4312
NP_689929                                                              17    4312
NP_060072                                                              17    4312
XP_005278099                                                           17    4312
XP_005272679                                                           17    4312
XP_006724600                                                           17    4312
XP_005278096                                                           17    4312
XP_005273892                                                           17    4312
XP_005273891                                                           17    4312
XP_005273890                                                           17    4312
NP_848563                                                              16    5631
NP_001265455                                                           16    7355
NP_004200                                                              16    7355
NP_001265454                                                           16    7355
NP_001265453                                                           16    7355
NP_835739                                                              16    7355
NP_055618                                                              16    7355
NP_001157877                                                           16    7355
XP_005271345                                                           16    7355
NP_116241                                                              16    7355
NP_775831                                                              15    9605
NP_001123453                                                           15    9605
NP_001278148                                                           15    9605
NP_001171899                                                           15    9605
NP_037436                                                              15    9605
NP_001165102                                                           15    9605
NP_056346                                                              15    9605
NP_689775                                                              15    9605
NP_009160                                                              15    9605
NP_443178                                                              15    9605
NP_001273506                                                           15    9605
NP_001171900                                                           15    9605
NP_001165103                                                           15    9605
NP_065825                                                              15    9605
NP_001034813                                                           15    9605
XP_005261376                                                           15    9605
XP_006724183                                                           15    9605
XP_006724182                                                           15    9605
XP_006724181                                                           15    9605
XP_006724180                                                           15    9605
XP_005255972                                                           15    9605
XP_006721248                                                           15    9605
XP_005255971                                                           15    9605
XP_005273954                                                           15    9605
XP_006718558                                                           15    9605
XP_005273953                                                           15    9605
XP_005273952                                                           15    9605
XP_005273950                                                           15    9605
XP_005273475                                                           15    9605
XP_006716359                                                           15    9605
XP_006716358                                                           15    9605
XP_006716357                                                           15    9605
XP_005246327                                                           15    9605
XP_006712296                                                           15    9605
NP_997260                                                              15    9605
NP_057607                                                              15    9605
NP_690862                                                              15    9605
>NP_002430
          Length = 1137

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NVRDKKR 7
           NVRDKK+
Sbjct: 377 NVRDKKK 383
>XP_006722198
          Length = 996

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  NVRDKKRA 8
          NV++KKRA
Sbjct: 66 NVKEKKRA 73
>XP_005257783
          Length = 999

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  NVRDKKRA 8
          NV++KKRA
Sbjct: 66 NVKEKKRA 73
>XP_005257782
          Length = 1000

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  NVRDKKRA 8
          NV++KKRA
Sbjct: 66 NVKEKKRA 73
>XP_006722197
          Length = 1010

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  NVRDKKRA 8
          NV++KKRA
Sbjct: 66 NVKEKKRA 73
>XP_006722196
          Length = 1011

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  NVRDKKRA 8
          NV++KKRA
Sbjct: 66 NVKEKKRA 73
>NP_115509
          Length = 984

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  NVRDKKRA 8
          NV++KKRA
Sbjct: 66 NVKEKKRA 73
>NP_002086
          Length = 291

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NVRDKK 6
           NVRDKK
Sbjct: 144 NVRDKK 149
>NP_001129631
          Length = 349

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 160 LEDKKRAT 167
>NP_001129630
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 377 LEDKKRAT 384
>NP_001129629
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 377 LEDKKRAT 384
>NP_689929
          Length = 770

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           VRDK+R T
Sbjct: 515 VRDKRRKT 522
>NP_060072
          Length = 571

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 382 LEDKKRAT 389
>XP_005278099
          Length = 355

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 165 LEDKKRAT 172
>XP_005272679
          Length = 567

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 377 LEDKKRAT 384
>XP_006724600
          Length = 571

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 382 LEDKKRAT 389
>XP_005278096
          Length = 572

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           + DKKRAT
Sbjct: 382 LEDKKRAT 389
>XP_005273892
          Length = 551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           VRDK+R T
Sbjct: 296 VRDKRRKT 303
>XP_005273891
          Length = 740

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           VRDK+R T
Sbjct: 485 VRDKRRKT 492
>XP_005273890
          Length = 770

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           VRDK+R T
Sbjct: 515 VRDKRRKT 522
>NP_848563
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           VRD+KR T
Sbjct: 714 VRDEKRLT 721
>NP_001265455
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           V+DK RAT
Sbjct: 371 VKDKLRAT 378
>NP_004200
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NVRDKKRA 8
           +VRD++RA
Sbjct: 97  SVRDRRRA 104
>NP_001265454
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           V+DK RAT
Sbjct: 901 VKDKLRAT 908
>NP_001265453
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           V+DK RAT
Sbjct: 901 VKDKLRAT 908
>NP_835739
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVRDKKRAT 9
           NV+D KRA+
Sbjct: 390 NVQDFKRAS 398
>NP_055618
          Length = 1483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           V+DK RAT
Sbjct: 901 VKDKLRAT 908
>NP_001157877
          Length = 235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NVRDKKR 7
          NVR++KR
Sbjct: 71 NVRERKR 77
>XP_005271345
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVRDKKRAT 9
           NV+D KRA+
Sbjct: 390 NVQDFKRAS 398
>NP_116241
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVRDKKRAT 9
           NV+D KRA+
Sbjct: 390 NVQDFKRAS 398
>NP_775831
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRDKKRAT 9
           V+DKK+ T
Sbjct: 114 VKDKKKQT 121
>NP_001123453
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           NVRDK+  T
Sbjct: 241 NVRDKEGDT 249
>NP_001278148
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           NVRDK+  T
Sbjct: 327 NVRDKEGDT 335
>NP_001171899
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 315 REKKKAT 321
>NP_037436
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NVRDKKRA 8
           NVRDK  A
Sbjct: 109 NVRDKSYA 116
>NP_001165102
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVRDKKR 7
           NV++KKR
Sbjct: 106 NVQEKKR 112
>NP_056346
          Length = 1963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NVRDKKRA 8
            NVRD+K A
Sbjct: 1120 NVRDQKVA 1127
>NP_689775
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           N+R +KR T
Sbjct: 386 NMRKRKRVT 394
>NP_009160
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 315 REKKKAT 321
>NP_443178
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NVRDKKR 7
          NV++KKR
Sbjct: 28 NVQEKKR 34
>NP_001273506
          Length = 2353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NVRDKKRA 8
            NVRD+K A
Sbjct: 1120 NVRDQKVA 1127
>NP_001171900
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 315 REKKKAT 321
>NP_001165103
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NVRDKKR 7
          NV++KKR
Sbjct: 78 NVQEKKR 84
>NP_065825
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           N R+K+R T
Sbjct: 524 NARNKRRQT 532
>NP_001034813
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVRDKKR 7
           NV++KKR
Sbjct: 106 NVQEKKR 112
>XP_005261376
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 315 REKKKAT 321
>XP_006724183
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 274 REKKKAT 280
>XP_006724182
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 315 REKKKAT 321
>XP_006724181
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 315 REKKKAT 321
>XP_006724180
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDKKRAT 9
           R+KK+AT
Sbjct: 315 REKKKAT 321
>XP_005255972
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NVRDKKRA 8
           NVRDK  A
Sbjct: 109 NVRDKSYA 116
>XP_006721248
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NVRDKKRA 8
           NVRDK  A
Sbjct: 109 NVRDKSYA 116
>XP_005255971
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NVRDKKRA 8
           NVRDK  A
Sbjct: 109 NVRDKSYA 116
>XP_005273954
          Length = 1676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NVRDKKRA 8
            NVRD+K A
Sbjct: 1120 NVRDQKVA 1127
>XP_006718558
          Length = 1841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVRDKKRA 8
           NVRD+K A
Sbjct: 607 NVRDQKVA 614
>XP_005273953
          Length = 2171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVRDKKRA 8
           NVRD+K A
Sbjct: 937 NVRDQKVA 944
>XP_005273952
          Length = 2245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NVRDKKRA 8
            NVRD+K A
Sbjct: 1011 NVRDQKVA 1018
>XP_005273950
          Length = 2354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NVRDKKRA 8
            NVRD+K A
Sbjct: 1120 NVRDQKVA 1127
>XP_005273475
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           N+R +KR T
Sbjct: 386 NMRKRKRVT 394
>XP_006716359
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           N+R +KR T
Sbjct: 391 NMRKRKRVT 399
>XP_006716358
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           N+R +KR T
Sbjct: 391 NMRKRKRVT 399
>XP_006716357
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVRDKKRAT 9
           N+R +KR T
Sbjct: 391 NMRKRKRVT 399
>XP_005246327
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVRDKKR 7
           NV++KKR
Sbjct: 106 NVQEKKR 112
>XP_006712296
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVRDKKR 7
           NV++KKR
Sbjct: 106 NVQEKKR 112
>NP_997260
          Length = 152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VRDKKRA 8
          +RDK+RA
Sbjct: 43 LRDKRRA 49
>NP_057607
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NVRDKKRAT 9
          NV+ KKR++
Sbjct: 11 NVQSKKRSS 19
>NP_690862
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NVRDKKR 7
           N+R++KR
Sbjct: 107 NIRERKR 113
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.121    0.313 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 514,087
Number of extensions: 714
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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