Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              19     665
NP_001091680                                                           19     665
NP_001091679                                                           19     665
XP_006713048                                                           19     665
XP_006713047                                                           19     665
XP_006713046                                                           19     665
XP_005264943                                                           19     665
NP_002221                                                              17    3301
NP_068831                                                              17    3301
XP_006721941                                                           17    3301
XP_006721940                                                           17    3301
XP_006721939                                                           17    3301
XP_006721938                                                           17    3301
XP_006721937                                                           17    3301
XP_006721936                                                           17    3301
XP_006721935                                                           17    3301
XP_006721934                                                           17    3301
XP_005257370                                                           17    3301
NP_733762                                                              17    4312
XP_006713860                                                           17    4312
XP_006713859                                                           17    4312
XP_005247910                                                           17    4312
XP_005247909                                                           17    4312
NP_006293                                                              16    7355
NP_001139630                                                           16    7355
NP_001277114                                                           16    7355
NP_068375                                                              16    7355

>NP_001895
          Length = 781

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVNFLAITT 9
           NV FLAITT
Sbjct: 290 NVKFLAITT 298



>NP_001091680
          Length = 781

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVNFLAITT 9
           NV FLAITT
Sbjct: 290 NVKFLAITT 298



>NP_001091679
          Length = 781

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVNFLAITT 9
           NV FLAITT
Sbjct: 290 NVKFLAITT 298



>XP_006713048
          Length = 720

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVNFLAITT 9
           NV FLAITT
Sbjct: 290 NVKFLAITT 298



>XP_006713047
          Length = 774

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVNFLAITT 9
           NV FLAITT
Sbjct: 283 NVKFLAITT 291



>XP_006713046
          Length = 774

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVNFLAITT 9
           NV FLAITT
Sbjct: 283 NVKFLAITT 291



>XP_005264943
          Length = 781

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVNFLAITT 9
           NV FLAITT
Sbjct: 290 NVKFLAITT 298



>NP_002221
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>NP_068831
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>XP_006721941
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>XP_006721940
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>XP_006721939
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>XP_006721938
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>XP_006721937
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>XP_006721936
          Length = 745

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 281 NPKFLAITT 289



>XP_006721935
          Length = 762

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 298 NPKFLAITT 306



>XP_006721934
          Length = 783

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 319 NPKFLAITT 327



>XP_005257370
          Length = 783

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NVNFLAITT 9
           N  FLAITT
Sbjct: 319 NPKFLAITT 327



>NP_733762
          Length = 982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVNFLAIT 8
           N NFLA+T
Sbjct: 249 NWNFLAVT 256



>XP_006713860
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVNFLAIT 8
           N NFLA+T
Sbjct: 277 NWNFLAVT 284



>XP_006713859
          Length = 966

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVNFLAIT 8
           N NFLA+T
Sbjct: 277 NWNFLAVT 284



>XP_005247910
          Length = 982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVNFLAIT 8
           N NFLA+T
Sbjct: 249 NWNFLAVT 256



>XP_005247909
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NVNFLAIT 8
           N NFLA+T
Sbjct: 277 NWNFLAVT 284



>NP_006293
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVNFLAI 7
           NVN+LA+
Sbjct: 757 NVNYLAL 763



>NP_001139630
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVNFLAI 7
           NVN+LA+
Sbjct: 651 NVNYLAL 657



>NP_001277114
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVNFLAI 7
           N+NF+AI
Sbjct: 141 NLNFMAI 147



>NP_068375
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NVNFLAI 7
           N+NF+AI
Sbjct: 151 NLNFMAI 157



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.133    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 320,386
Number of extensions: 288
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)