Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_598397                                                              17    2528
NP_004728                                                              17    2528
NP_001245240                                                           17    2528
XP_006724438                                                           17    2528
XP_005261889                                                           17    2528
XP_005261888                                                           17    2528
NP_036601                                                              16    7355
NP_001243481                                                           16    7355
NP_078884                                                              16    7355
NP_085150                                                              16    7355
XP_006723832                                                           16    7355
XP_006720745                                                           16    7355
XP_005254716                                                           16    7355
XP_006720744                                                           16    7355
XP_006720743                                                           16    7355
XP_006720742                                                           16    7355
XP_006720740                                                           16    7355
NP_001182657                                                           15    9605
NP_004162                                                              15    9605
NP_001239581                                                           15    9605
NP_001273712                                                           15    9605
NP_443169                                                              15    9605
NP_001230050                                                           15    9605
NP_001104779                                                           15    9605
NP_006193                                                              15    9605
NP_001104778                                                           15    9605
NP_001104777                                                           15    9605
NP_001258029                                                           15    9605
NP_001129505                                                           15    9605
NP_659410                                                              15    9605
NP_055096                                                              15    9605
NP_510965                                                              15    9605
NP_001032416                                                           15    9605
NP_002591                                                              15    9605
NP_001258028                                                           15    9605
NP_001258026                                                           15    9605
NP_001032418                                                           15    9605
NP_001273711                                                           15    9605
NP_078895                                                              15    9605
NP_001258025                                                           15    9605
NP_001258027                                                           15    9605
XP_005259990                                                           15    9605
XP_006722828                                                           15    9605
XP_005253387                                                           15    9605
XP_006719103                                                           15    9605
XP_005253384                                                           15    9605
XP_005253383                                                           15    9605
XP_005253124                                                           15    9605
XP_006718340                                                           15    9605
XP_005253123                                                           15    9605
XP_005270983                                                           15    9605
XP_005270981                                                           15    9605
XP_005270982                                                           15    9605
XP_006710743                                                           15    9605
XP_005270980                                                           15    9605
NP_001032417                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NVLRNMVMK 9
            N LRNMVMK
Sbjct: 3607 NDLRNMVMK 3615
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NVLRNMVMK 9
            N LRNMVMK
Sbjct: 3599 NDLRNMVMK 3607
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NVLRNMVMK 9
            N LRNMVMK
Sbjct: 3560 NDLRNMVMK 3568
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NVLRNMVMK 9
            N LRNMVMK
Sbjct: 3639 NDLRNMVMK 3647
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NVLRNMVMK 9
            N LRNMVMK
Sbjct: 3652 NDLRNMVMK 3660
>NP_598397
          Length = 756

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVLRNMVMK 9
           N+LRN+ MK
Sbjct: 544 NLLRNVAMK 552
>NP_004728
          Length = 756

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVLRNMVMK 9
           N+LRN+ MK
Sbjct: 544 NLLRNVAMK 552
>NP_001245240
          Length = 524

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NVLRNMVMK 9
           NVL+NMV++
Sbjct: 133 NVLKNMVVQ 141
>XP_006724438
          Length = 577

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVLRNMVMK 9
           N+LRN+ MK
Sbjct: 544 NLLRNVAMK 552
>XP_005261889
          Length = 756

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVLRNMVMK 9
           N+LRN+ MK
Sbjct: 544 NLLRNVAMK 552
>XP_005261888
          Length = 756

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NVLRNMVMK 9
           N+LRN+ MK
Sbjct: 544 NLLRNVAMK 552
>NP_036601
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VLRNMVMK 9
           V RN++MK
Sbjct: 327 VARNLIMK 334
>NP_001243481
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 233 NVLRNLADK 241
>NP_078884
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 147 NVLRNLADK 155
>NP_085150
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NV+RN + K
Sbjct: 701 NVMRNFLQK 709
>XP_006723832
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VLRNMVMK 9
           V RN++MK
Sbjct: 327 VARNLIMK 334
>XP_006720745
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 147 NVLRNLADK 155
>XP_005254716
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 147 NVLRNLADK 155
>XP_006720744
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 147 NVLRNLADK 155
>XP_006720743
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 147 NVLRNLADK 155
>XP_006720742
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 190 NVLRNLADK 198
>XP_006720740
          Length = 467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           NVLRN+  K
Sbjct: 224 NVLRNLADK 232
>NP_001182657
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+L  +VMK
Sbjct: 262 NILNEIVMK 270
>NP_004162
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+L  +VMK
Sbjct: 271 NILNEIVMK 279
>NP_001239581
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+L  +VMK
Sbjct: 262 NILNEIVMK 270
>NP_001273712
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+LR  +MK
Sbjct: 156 NLLREKIMK 164
>NP_443169
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+LR  +MK
Sbjct: 332 NLLREKIMK 340
>NP_001230050
          Length = 864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 560 VLRNMV 565
>NP_001104779
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 521 VLRNMV 526
>NP_006193
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 343 VLRNMV 348
>NP_001104778
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 556 VLRNMV 561
>NP_001104777
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 582 VLRNMV 587
>NP_001258029
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 405 VLRNMV 410
>NP_001129505
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 422 VLRNMV 427
>NP_659410
          Length = 1274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LRNMVMK 9
           L+NMV+K
Sbjct: 420 LKNMVLK 426
>NP_055096
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 448 VLRNMV 453
>NP_510965
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 465 VLRNMV 470
>NP_001032416
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 383 VLRNMV 388
>NP_002591
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 555 VLRNMV 560
>NP_001258028
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 436 VLRNMV 441
>NP_001258026
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 419 VLRNMV 424
>NP_001032418
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 555 VLRNMV 560
>NP_001273711
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+LR  +MK
Sbjct: 256 NLLREKIMK 264
>NP_078895
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NVLRNMV 7
           N++RN+V
Sbjct: 302 NIMRNLV 308
>NP_001258025
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 447 VLRNMV 452
>NP_001258027
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 464 VLRNMV 469
>XP_005259990
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 278 VLRNMV 283
>XP_006722828
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 395 VLRNMV 400
>XP_005253387
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LRNMVMK 9
           L+NMV+K
Sbjct: 265 LKNMVLK 271
>XP_006719103
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LRNMVMK 9
           L+NMV+K
Sbjct: 442 LKNMVLK 448
>XP_005253384
          Length = 1311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LRNMVMK 9
           L+NMV+K
Sbjct: 420 LKNMVLK 426
>XP_005253383
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LRNMVMK 9
           L+NMV+K
Sbjct: 442 LKNMVLK 448
>XP_005253124
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+L  +VMK
Sbjct: 268 NILNEIVMK 276
>XP_006718340
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+L  +VMK
Sbjct: 276 NILNEIVMK 284
>XP_005253123
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NVLRNMVMK 9
           N+L  +VMK
Sbjct: 287 NILNEIVMK 295
>XP_005270983
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 322 VLRNMV 327
>XP_005270981
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 336 VLRNMV 341
>XP_005270982
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 336 VLRNMV 341
>XP_006710743
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 350 VLRNMV 355
>XP_005270980
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 358 VLRNMV 363
>NP_001032417
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VLRNMV 7
           VLRNMV
Sbjct: 540 VLRNMV 545
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.134    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 294,845
Number of extensions: 542
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package