Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              20     509
NP_059984                                                              16    5631
NP_060212                                                              16    5631
XP_006724893                                                           16    5631
XP_005274763                                                           16    5631
XP_006724892                                                           16    5631
XP_005274762                                                           16    5631
XP_006722557                                                           16    5631
XP_006722556                                                           16    5631
NP_001243297                                                           16    7355
NP_004817                                                              16    7355
NP_001277716                                                           16    7355
NP_940918                                                              16    7355
NP_001186804                                                           16    7355
NP_001254                                                              16    7355
NP_001123367                                                           16    7355
XP_005276467                                                           16    7355
XP_006722869                                                           16    7355
XP_005272548                                                           16    7355
XP_006720086                                                           16    7355
XP_006720085                                                           16    7355
XP_006720084                                                           16    7355
XP_006718287                                                           16    7355
XP_005262744                                                           16    7355
XP_005263976                                                           16    7355
NP_003699                                                              16    7355
NP_006579                                                              16    7355
NP_940857                                                              16    7355
NP_065953                                                              16    7355
NP_001073898                                                           16    7355
NP_065988                                                              15    9605
NP_001068567                                                           15    9605
NP_003717                                                              15    9605
NP_002825                                                              15    9605
NP_001264128                                                           15    9605
NP_054903                                                              15    9605
NP_001264129                                                           15    9605
NP_002198                                                              15    9605
NP_874358                                                              15    9605
NP_597713                                                              15    9605
NP_001166171                                                           15    9605
NP_060349                                                              15    9605
NP_001180473                                                           15    9605
NP_001146                                                              15    9605
XP_005259108                                                           15    9605
XP_005257813                                                           15    9605
XP_005257814                                                           15    9605
XP_005257812                                                           15    9605
XP_005267986                                                           15    9605
XP_006719590                                                           15    9605
XP_006719589                                                           15    9605
XP_005268489                                                           15    9605
XP_005271944                                                           15    9605
XP_005271943                                                           15    9605
XP_006714596                                                           15    9605
XP_005271942                                                           15    9605
XP_006711831                                                           15    9605
>NP_115803
          Length = 1156

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NVGIMQPTA 9
           NVG MQPTA
Sbjct: 807 NVGNMQPTA 815
>NP_059984
          Length = 1871

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VGIMQP 7
           VG+MQP
Sbjct: 696 VGVMQP 701
>NP_060212
          Length = 1178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGIMQPTA 9
           VGI+ PTA
Sbjct: 770 VGILGPTA 777
>XP_006724893
          Length = 1719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VGIMQP 7
           VG+MQP
Sbjct: 696 VGVMQP 701
>XP_005274763
          Length = 1789

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VGIMQP 7
           VG+MQP
Sbjct: 614 VGVMQP 619
>XP_006724892
          Length = 1841

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VGIMQP 7
           VG+MQP
Sbjct: 696 VGVMQP 701
>XP_005274762
          Length = 1853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VGIMQP 7
           VG+MQP
Sbjct: 696 VGVMQP 701
>XP_006722557
          Length = 1076

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGIMQPTA 9
           VGI+ PTA
Sbjct: 668 VGILGPTA 675
>XP_006722556
          Length = 1100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGIMQPTA 9
           VGI+ PTA
Sbjct: 692 VGILGPTA 699
>NP_001243297
          Length = 102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  NVGIMQP 7
          N+G++QP
Sbjct: 31 NLGLLQP 37
>NP_004817
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GIMQPT 8
           GI+QPT
Sbjct: 586 GILQPT 591
>NP_001277716
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GIMQPT 8
           GI+QPT
Sbjct: 584 GILQPT 589
>NP_940918
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVGIMQPT 8
           +VGI+ PT
Sbjct: 515 HVGILSPT 522
>NP_001186804
          Length = 170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  VGIMQPTA 9
          VG+ QP A
Sbjct: 40 VGVQQPNA 47
>NP_001254
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GIMQPT 8
           GI+QPT
Sbjct: 453 GILQPT 458
>NP_001123367
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GIMQPTA 9
           G+M PTA
Sbjct: 126 GVMTPTA 132
>XP_005276467
          Length = 97

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  NVGIMQP 7
          N+G++QP
Sbjct: 91 NLGLLQP 97
>XP_006722869
          Length = 1260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NVGIMQPTA 9
            N+G+ +PT+
Sbjct: 1073 NLGVKRPTS 1081
>XP_005272548
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NVGIMQPTA 9
            N+G+ +PT+
Sbjct: 1078 NLGVKRPTS 1086
>XP_006720086
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NVGIMQP 7
           N+G++QP
Sbjct: 691 NLGLLQP 697
>XP_006720085
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NVGIMQP 7
           N+G++QP
Sbjct: 692 NLGLLQP 698
>XP_006720084
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NVGIMQP 7
           N+G++QP
Sbjct: 718 NLGLLQP 724
>XP_006718287
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVGIMQPT 8
           +VGI+ PT
Sbjct: 453 HVGILSPT 460
>XP_005262744
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GIMQPT 8
           GI+QPT
Sbjct: 413 GILQPT 418
>XP_005263976
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  GIMQPT 8
          GI+QPT
Sbjct: 24 GILQPT 29
>NP_003699
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NVGIMQPTA 9
           N GI  PTA
Sbjct: 112 NAGISLPTA 120
>NP_006579
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  GIMQPT 8
          GI+QPT
Sbjct: 24 GILQPT 29
>NP_940857
          Length = 5147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    GIMQPTA 9
            G+++PTA
Sbjct: 1162 GVLEPTA 1168
>NP_065953
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NVGIMQPTA 9
            N+G+ +PT+
Sbjct: 1062 NLGVKRPTS 1070
>NP_001073898
          Length = 1276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NVGIMQPTA 9
            N+G+ +PT+
Sbjct: 1089 NLGVKRPTS 1097
>NP_065988
          Length = 2048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NVGIMQPT 8
            NVGI  PT
Sbjct: 1956 NVGIHVPT 1963
>NP_001068567
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVGIMQPT 8
           +VGI +PT
Sbjct: 255 SVGIKEPT 262
>NP_003717
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVGIMQPT 8
           +VGI +PT
Sbjct: 255 SVGIKEPT 262
>NP_002825
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVGIMQ 6
           NVG+MQ
Sbjct: 582 NVGLMQ 587
>NP_001264128
          Length = 76

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  NVGIMQPT 8
          N+G+  PT
Sbjct: 29 NMGVFDPT 36
>NP_054903
          Length = 139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  NVGIMQPT 8
          N+G+  PT
Sbjct: 92 NMGVFDPT 99
>NP_001264129
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  NVGIMQPT 8
          N+G+  PT
Sbjct: 92 NMGVFDPT 99
>NP_002198
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GIMQPTA 9
           GIM PT+
Sbjct: 775 GIMSPTS 781
>NP_874358
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VGIMQPT 8
           VGI++PT
Sbjct: 240 VGIVKPT 246
>NP_597713
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGIMQPTA 9
           +VGI +PT+
Sbjct: 460 SVGISRPTS 468
>NP_001166171
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGIMQPTA 9
           +VGI +PT+
Sbjct: 460 SVGISRPTS 468
>NP_060349
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGIMQPTA 9
           +GI+QP A
Sbjct: 184 LGILQPQA 191
>NP_001180473
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VGIMQPTA 9
          VG+M+P A
Sbjct: 55 VGLMRPPA 62
>NP_001146
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VGIMQPTA 9
          VG+M+P A
Sbjct: 87 VGLMRPPA 94
>XP_005259108
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGIMQPTA 9
           +GI+QP A
Sbjct: 112 LGILQPQA 119
>XP_005257813
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVGIMQPT 8
           +VGI +PT
Sbjct: 161 SVGIKEPT 168
>XP_005257814
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVGIMQPT 8
           +VGI +PT
Sbjct: 161 SVGIKEPT 168
>XP_005257812
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NVGIMQPT 8
           +VGI +PT
Sbjct: 255 SVGIKEPT 262
>XP_005267986
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NVGIMQPT 8
            NVGI  PT
Sbjct: 1930 NVGIHVPT 1937
>XP_006719590
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVGIMQ 6
           NVG+MQ
Sbjct: 548 NVGLMQ 553
>XP_006719589
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NVGIMQ 6
           NVG+MQ
Sbjct: 586 NVGLMQ 591
>XP_005268489
          Length = 667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VGIMQPTA 9
          VG+M+P A
Sbjct: 87 VGLMRPPA 94
>XP_005271944
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGIMQPTA 9
           +VGI +PT+
Sbjct: 460 SVGISRPTS 468
>XP_005271943
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGIMQPTA 9
           +VGI +PT+
Sbjct: 460 SVGISRPTS 468
>XP_006714596
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGIMQPTA 9
           +VGI +PT+
Sbjct: 460 SVGISRPTS 468
>XP_005271942
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NVGIMQPTA 9
           +VGI +PT+
Sbjct: 460 SVGISRPTS 468
>XP_006711831
          Length = 76

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  NVGIMQPT 8
          N+G+  PT
Sbjct: 29 NMGVFDPT 36
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.129    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 753,904
Number of extensions: 1294
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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