Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              21     175
NP_001015882                                                           18    1482
NP_003791                                                              17    2528
NP_001273357                                                           17    2528
NP_001273355                                                           17    2528
XP_006715652                                                           17    2528
NP_001010909                                                           17    3301
XP_005275464                                                           17    3301
XP_005275463                                                           17    3301
XP_005275181                                                           17    3301
XP_005275180                                                           17    3301
NP_001135817                                                           17    4312
NP_001135815                                                           17    4312
NP_001135816                                                           17    4312
NP_004063                                                              17    4312
NP_001264771                                                           16    5631
NP_001231                                                              16    5631
NP_001784                                                              16    5631
NP_490595                                                              16    5631
XP_005263887                                                           16    5631
NP_001232                                                              16    5631
NP_689730                                                              16    5631
NP_689488                                                              16    5631
NP_002290                                                              16    7355
NP_776183                                                              16    7355
XP_005246532                                                           16    7355
XP_006712507                                                           16    7355
XP_006712506                                                           16    7355
XP_006712505                                                           16    7355
XP_006712504                                                           16    7355
XP_005246531                                                           16    7355
NP_004955                                                              15    9605
NP_001518                                                              15    9605
NP_079066                                                              15    9605
NP_001278268                                                           15    9605
NP_001032208                                                           15    9605
NP_055729                                                              15    9605
NP_001276109                                                           15    9605
NP_001276108                                                           15    9605
NP_001276106                                                           15    9605
XP_005259710                                                           15    9605
XP_006722978                                                           15    9605
XP_006716543                                                           15    9605
XP_006716542                                                           15    9605
XP_006716541                                                           15    9605
XP_006716540                                                           15    9605
XP_006716539                                                           15    9605
XP_006716538                                                           15    9605
XP_005251368                                                           15    9605
XP_006716537                                                           15    9605
XP_006716536                                                           15    9605
XP_005251364                                                           15    9605
XP_006716535                                                           15    9605
XP_006716534                                                           15    9605
XP_006716533                                                           15    9605
XP_006716532                                                           15    9605
XP_005251363                                                           15    9605
XP_005251362                                                           15    9605
XP_006712302                                                           15    9605
XP_006712301                                                           15    9605
XP_006712300                                                           15    9605
XP_005246116                                                           15    9605
XP_006712299                                                           15    9605
XP_005246115                                                           15    9605
XP_006712298                                                           15    9605
XP_006712297                                                           15    9605
XP_006711659                                                           15    9605
XP_005277493                                                           15    9605
XP_005277492                                                           15    9605
XP_005277490                                                           15    9605
XP_005277491                                                           15    9605
XP_005277489                                                           15    9605
NP_003628                                                              15    9605
NP_112186                                                              15    9605
NP_001276107                                                           15    9605
>NP_004351
          Length = 882

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NTYN AIAY
Sbjct: 294 NTYNAAIAY 302
>NP_001015882
          Length = 360

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           N+YN AI+Y
Sbjct: 169 NSYNKAISY 177
>NP_003791
          Length = 597

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNTA+A
Sbjct: 537 NAYNTAMA 544
>NP_001273357
          Length = 514

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNTA+A
Sbjct: 454 NAYNTAMA 461
>NP_001273355
          Length = 574

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNTA+A
Sbjct: 514 NAYNTAMA 521
>XP_006715652
          Length = 574

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNTA+A
Sbjct: 514 NAYNTAMA 521
>NP_001010909
          Length = 566

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTYNTAI 7
           NT+NTA+
Sbjct: 510 NTFNTAV 516
>XP_005275464
          Length = 572

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTYNTAI 7
           NT+NTA+
Sbjct: 516 NTFNTAV 522
>XP_005275463
          Length = 626

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTYNTAI 7
           NT+NTA+
Sbjct: 570 NTFNTAV 576
>XP_005275181
          Length = 572

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTYNTAI 7
           NT+NTA+
Sbjct: 516 NTFNTAV 522
>XP_005275180
          Length = 596

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTYNTAI 7
           NT+NTA+
Sbjct: 540 NTFNTAV 546
>NP_001135817
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YNTAIAY 9
          YNT+I+Y
Sbjct: 8  YNTSISY 14
>NP_001135815
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YNTAIAY 9
          YNT+I+Y
Sbjct: 8  YNTSISY 14
>NP_001135816
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YNTAIAY 9
          YNT+I+Y
Sbjct: 8  YNTSISY 14
>NP_004063
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YNTAIAY 9
          YNT+I+Y
Sbjct: 6  YNTSISY 12
>NP_001264771
          Length = 184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TYNTAIAY 9
          T NTAI Y
Sbjct: 58 TINTAIVY 65
>NP_001231
          Length = 726

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TYNTAIAY 9
          T NTAI Y
Sbjct: 58 TINTAIVY 65
>NP_001784
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TYNTAIAY 9
           TYN  +AY
Sbjct: 248 TYNGVVAY 255
>NP_490595
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TYNTAIAY 9
          T NTAI Y
Sbjct: 57 TINTAIVY 64
>XP_005263887
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TYNTAIAY 9
          T NTAI Y
Sbjct: 57 TINTAIVY 64
>NP_001232
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TYNTAIAY 9
          T NTAI Y
Sbjct: 57 TINTAIVY 64
>NP_689730
          Length = 665

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYNTAIAY 9
           +YN A+AY
Sbjct: 191 SYNLALAY 198
>NP_689488
          Length = 665

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TYNTAIAY 9
           +YN A+AY
Sbjct: 191 SYNLALAY 198
>NP_002290
          Length = 1927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NTYNTAIAY 9
            N Y T +AY
Sbjct: 1681 NHYTTVLAY 1689
>NP_776183
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_005246532
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YN+AI Y
Sbjct: 106 YNSAIVY 112
>XP_006712507
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_006712506
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_006712505
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_006712504
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>XP_005246531
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YN+AI Y
Sbjct: 188 YNSAIVY 194
>NP_004955
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYNTAIA 8
           TY TA+A
Sbjct: 313 TYETAVA 319
>NP_001518
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TYNTAIA 8
           TY TA+A
Sbjct: 314 TYETAVA 320
>NP_079066
          Length = 1221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 526 NTFDPSLAY 534
>NP_001278268
          Length = 876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 232 NTFDPSLAY 240
>NP_001032208
          Length = 857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 803 NTALAY 808
>NP_055729
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 750 NTALAY 755
>NP_001276109
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YNT ++Y
Sbjct: 178 YNTPVSY 184
>NP_001276108
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>NP_001276106
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>XP_005259710
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>XP_006722978
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>XP_006716543
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 561 NTFDPSLAY 569
>XP_006716542
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 561 NTFDPSLAY 569
>XP_006716541
          Length = 1032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 561 NTFDPSLAY 569
>XP_006716540
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 384 NTFDPSLAY 392
>XP_006716539
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 561 NTFDPSLAY 569
>XP_006716538
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 526 NTFDPSLAY 534
>XP_005251368
          Length = 1185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 490 NTFDPSLAY 498
>XP_006716537
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 561 NTFDPSLAY 569
>XP_006716536
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 517 NTFDPSLAY 525
>XP_005251364
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 517 NTFDPSLAY 525
>XP_006716535
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 525 NTFDPSLAY 533
>XP_006716534
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 525 NTFDPSLAY 533
>XP_006716533
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 525 NTFDPSLAY 533
>XP_006716532
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 528 NTFDPSLAY 536
>XP_005251363
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 553 NTFDPSLAY 561
>XP_005251362
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NTYNTAIAY 9
           NT++ ++AY
Sbjct: 561 NTFDPSLAY 569
>XP_006712302
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 728 NTALAY 733
>XP_006712301
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 694 NTALAY 699
>XP_006712300
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 694 NTALAY 699
>XP_005246116
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 754 NTALAY 759
>XP_006712299
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 779 NTALAY 784
>XP_005246115
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 807 NTALAY 812
>XP_006712298
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 828 NTALAY 833
>XP_006712297
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NTAIAY 9
           NTA+AY
Sbjct: 832 NTALAY 837
>XP_006711659
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNT+++
Sbjct: 715 NAYNTSLS 722
>XP_005277493
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNT+++
Sbjct: 774 NAYNTSLS 781
>XP_005277492
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNT+++
Sbjct: 788 NAYNTSLS 795
>XP_005277490
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNT+++
Sbjct: 850 NAYNTSLS 857
>XP_005277491
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNT+++
Sbjct: 850 NAYNTSLS 857
>XP_005277489
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNT+++
Sbjct: 850 NAYNTSLS 857
>NP_003628
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NTYNTAIA 8
           N YNT+++
Sbjct: 836 NAYNTSLS 843
>NP_112186
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YNT ++Y
Sbjct: 365 YNTPVSY 371
>NP_001276107
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   YNTAIAY 9
           YNT ++Y
Sbjct: 365 YNTPVSY 371
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.119    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,117
Number of extensions: 653
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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