Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           20     299
NP_055903                                                              20     299
NP_003289                                                              17    3301
XP_006713383                                                           17    3301
XP_005265485                                                           17    3301
NP_008995                                                              16    5631
NP_001019831                                                           16    5631
NP_005307                                                              16    5631
NP_001135779                                                           16    5631
XP_006718271                                                           16    5631
XP_006713877                                                           16    5631
XP_006713876                                                           16    5631
XP_006713875                                                           16    5631
XP_006713874                                                           16    5631
XP_006713873                                                           16    5631
NP_004960                                                              16    7355
NP_060733                                                              16    7355
NP_056432                                                              16    7355
XP_005262467                                                           16    7355
XP_005262466                                                           16    7355
XP_005262465                                                           16    7355
XP_005254357                                                           16    7355
XP_005269826                                                           16    7355
XP_005269823                                                           16    7355
XP_006712103                                                           16    7355
XP_006712102                                                           16    7355
NP_001094827                                                           16    7355
NP_005142                                                              15    9605
NP_001032411                                                           15    9605
NP_004124                                                              15    9605
NP_001030331                                                           15    9605
NP_060034                                                              15    9605
NP_005453                                                              15    9605
NP_078873                                                              15    9605
NP_001166988                                                           15    9605
NP_201567                                                              15    9605
NP_001242992                                                           15    9605
NP_003476                                                              15    9605
NP_001171147                                                           15    9605
NP_001166987                                                           15    9605
NP_001242993                                                           15    9605
NP_778203                                                              15    9605
NP_001834                                                              15    9605
NP_149095                                                              15    9605
NP_001243359                                                           15    9605
NP_001093591                                                           15    9605
NP_001093590                                                           15    9605
NP_976050                                                              15    9605
NP_542391                                                              15    9605
XP_005262529                                                           15    9605
XP_006722063                                                           15    9605
XP_006722062                                                           15    9605
XP_006722061                                                           15    9605
XP_006722060                                                           15    9605
XP_005257605                                                           15    9605
XP_005257604                                                           15    9605
XP_006722059                                                           15    9605
XP_006720342                                                           15    9605
XP_005268169                                                           15    9605
XP_006720326                                                           15    9605
XP_005268168                                                           15    9605
XP_006720325                                                           15    9605
XP_005268167                                                           15    9605
XP_006719539                                                           15    9605
XP_006719304                                                           15    9605
XP_005268708                                                           15    9605
XP_005252041                                                           15    9605
XP_003846820                                                           15    9605
NP_001032401                                                           15    9605
NP_055508                                                              15    9605
>NP_001155973
          Length = 1833

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NTTDNSSAS 9
           NTTDN+SAS
Sbjct: 214 NTTDNNSAS 222
>NP_055903
          Length = 1723

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NTTDNSSAS 9
           NTTDN+SAS
Sbjct: 214 NTTDNNSAS 222
>NP_003289
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NTTDNSSA 8
           NTTD+SS+
Sbjct: 340 NTTDSSSS 347
>XP_006713383
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NTTDNSSA 8
           NTTD+SS+
Sbjct: 340 NTTDSSSS 347
>XP_005265485
          Length = 596

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NTTDNSSA 8
           NTTD+SS+
Sbjct: 321 NTTDSSSS 328
>NP_008995
          Length = 1289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TDNSSAS 9
           TDNSSA+
Sbjct: 817 TDNSSAT 823
>NP_001019831
          Length = 2986

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TDNSSAS 9
            TDNSSA+
Sbjct: 2514 TDNSSAT 2520
>NP_005307
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTTDNSSAS 9
           N TD+SS S
Sbjct: 150 NATDSSSTS 158
>NP_001135779
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTTDNSSAS 9
           N TD+SS S
Sbjct: 150 NATDSSSTS 158
>XP_006718271
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTTDNSSAS 9
           N TD+SS S
Sbjct: 150 NATDSSSTS 158
>XP_006713877
          Length = 2956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TDNSSAS 9
            TDNSSA+
Sbjct: 2484 TDNSSAT 2490
>XP_006713876
          Length = 2966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TDNSSAS 9
            TDNSSA+
Sbjct: 2494 TDNSSAT 2500
>XP_006713875
          Length = 2975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TDNSSAS 9
            TDNSSA+
Sbjct: 2503 TDNSSAT 2509
>XP_006713874
          Length = 2979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TDNSSAS 9
            TDNSSA+
Sbjct: 2507 TDNSSAT 2513
>XP_006713873
          Length = 2988

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TDNSSAS 9
            TDNSSA+
Sbjct: 2516 TDNSSAT 2522
>NP_004960
          Length = 1019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TTDNSSAS 9
          TTD SSA+
Sbjct: 82 TTDKSSAA 89
>NP_060733
          Length = 1435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NTTDNSS 7
            NTT+NS+
Sbjct: 997  NTTENST 1003
>NP_056432
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NTTDNSSA 8
           NT  NSSA
Sbjct: 248 NTNQNSSA 255
>XP_005262467
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NTTDNSSAS 9
          N TD +SAS
Sbjct: 89 NETDTNSAS 97
>XP_005262466
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NTTDNSSAS 9
          N TD +SAS
Sbjct: 89 NETDTNSAS 97
>XP_005262465
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTTDNSSAS 9
           N TD +SAS
Sbjct: 98  NETDTNSAS 106
>XP_005254357
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NTTDNSSA 8
           NT  NSSA
Sbjct: 248 NTNQNSSA 255
>XP_005269826
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TTDNSSAS 9
          TTD SSA+
Sbjct: 82 TTDKSSAA 89
>XP_005269823
          Length = 1019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TTDNSSAS 9
          TTD SSA+
Sbjct: 82 TTDKSSAA 89
>XP_006712103
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTTDNSS 7
           NTT+NS+
Sbjct: 737 NTTENST 743
>XP_006712102
          Length = 1313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTTDNSS 7
           NTT+NS+
Sbjct: 875 NTTENST 881
>NP_001094827
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NTTDNSSAS 9
          N TD +SAS
Sbjct: 89 NETDTNSAS 97
>NP_005142
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TDNSSAS 9
           TD+SSAS
Sbjct: 226 TDSSSAS 232
>NP_001032411
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TDNSSAS 9
           TD+SSAS
Sbjct: 191 TDSSSAS 197
>NP_004124
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NTTDN 5
          NTTDN
Sbjct: 39 NTTDN 43
>NP_001030331
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NTTDNSSAS 9
           NT+ +SSAS
Sbjct: 260 NTSTSSSAS 268
>NP_060034
          Length = 2551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NTTDN 5
           NTTDN
Sbjct: 619 NTTDN 623
>NP_005453
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    NTTDNSSAS 9
            +TTD+S+A+
Sbjct: 1119 DTTDDSTAT 1127
>NP_078873
          Length = 876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NTTDNSSA 8
           NTT  SSA
Sbjct: 849 NTTSRSSA 856
>NP_001166988
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NTTDNSSA 8
           NTT  SSA
Sbjct: 814 NTTSRSSA 821
>NP_201567
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NTTDNSSAS 9
          N+T NSS S
Sbjct: 78 NSTSNSSHS 86
>NP_001242992
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DNSSAS 9
           DNSSAS
Sbjct: 590 DNSSAS 595
>NP_003476
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTDNSSAS 9
          T DNSS S
Sbjct: 5  TADNSSMS 12
>NP_001171147
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTDNSSAS 9
          T DNSS S
Sbjct: 5  TADNSSMS 12
>NP_001166987
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NTTDNSSA 8
           NTT  SSA
Sbjct: 831 NTTSRSSA 838
>NP_001242993
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DNSSAS 9
           DNSSAS
Sbjct: 590 DNSSAS 595
>NP_778203
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DNSSAS 9
           DNSSAS
Sbjct: 579 DNSSAS 584
>NP_001834
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DNSSAS 9
           DNSSAS
Sbjct: 590 DNSSAS 595
>NP_149095
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTTDNSSA 8
           ++TDNSS+
Sbjct: 188 DSTDNSSS 195
>NP_001243359
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTTDNSSA 8
           ++TDNSS+
Sbjct: 188 DSTDNSSS 195
>NP_001093591
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTTDNSSA 8
           NTT NSS+
Sbjct: 161 NTTFNSSS 168
>NP_001093590
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTTDNSSA 8
           NTT NSS+
Sbjct: 207 NTTFNSSS 214
>NP_976050
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NTTDNSSAS 9
           NT+ +SSAS
Sbjct: 118 NTSTSSSAS 126
>NP_542391
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TDNSSAS 9
           TDNSS S
Sbjct: 253 TDNSSPS 259
>XP_005262529
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NTTDNSSA 8
           NTT  SSA
Sbjct: 848 NTTSRSSA 855
>XP_006722063
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TTDNSSAS 9
           TTD  SAS
Sbjct: 221 TTDTDSAS 228
>XP_006722062
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TTDNSSAS 9
           TTD  SAS
Sbjct: 221 TTDTDSAS 228
>XP_006722061
          Length = 1913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TTDNSSAS 9
           TTD  SAS
Sbjct: 221 TTDTDSAS 228
>XP_006722060
          Length = 1915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TTDNSSAS 9
           TTD  SAS
Sbjct: 221 TTDTDSAS 228
>XP_005257605
          Length = 1926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TTDNSSAS 9
           TTD  SAS
Sbjct: 221 TTDTDSAS 228
>XP_005257604
          Length = 1962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TTDNSSAS 9
           TTD  SAS
Sbjct: 221 TTDTDSAS 228
>XP_006722059
          Length = 1965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TTDNSSAS 9
           TTD  SAS
Sbjct: 221 TTDTDSAS 228
>XP_006720342
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTTDNSSA 8
           ++TDNSS+
Sbjct: 188 DSTDNSSS 195
>XP_005268169
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTDNSSAS 9
          T DNSS S
Sbjct: 15 TADNSSMS 22
>XP_006720326
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTDNSSAS 9
          T DNSS S
Sbjct: 15 TADNSSMS 22
>XP_005268168
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTDNSSAS 9
          T DNSS S
Sbjct: 15 TADNSSMS 22
>XP_006720325
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTDNSSAS 9
          T DNSS S
Sbjct: 15 TADNSSMS 22
>XP_005268167
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTDNSSAS 9
          T DNSS S
Sbjct: 15 TADNSSMS 22
>XP_006719539
          Length = 2246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NTTDN 5
           NTTDN
Sbjct: 619 NTTDN 623
>XP_006719304
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DNSSAS 9
           DNSSAS
Sbjct: 590 DNSSAS 595
>XP_005268708
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DNSSAS 9
           DNSSAS
Sbjct: 590 DNSSAS 595
>XP_005252041
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NTTDNSSAS 9
           NT+ +SSAS
Sbjct: 118 NTSTSSSAS 126
>XP_003846820
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    NTTDNSSAS 9
            +TTD+S+A+
Sbjct: 1154 DTTDDSTAT 1162
>NP_001032401
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTTDNSSA 8
           NTT NSS+
Sbjct: 132 NTTFNSSS 139
>NP_055508
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTTDNSSA 8
           NTT NSS+
Sbjct: 279 NTTFNSSS 286
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.266   0.0827    0.186 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 523,567
Number of extensions: 983
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 19 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.3 bits)
S2: 28 (15.4 bits)

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