Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              20     299
XP_005250598                                                           20     299
NP_443086                                                              18    1135
NP_112572                                                              17    3301
NP_705833                                                              17    3301
XP_005247174                                                           17    3301
NP_115766                                                              17    4312
NP_060862                                                              17    4312
XP_005263172                                                           17    4312
NP_000005                                                              16    5631
XP_006719119                                                           16    5631
NP_001159719                                                           16    7355
NP_068775                                                              16    7355
NP_786944                                                              16    7355
NP_055178                                                              16    7355
NP_001269524                                                           16    7355
NP_067004                                                              16    7355
NP_001269518                                                           16    7355
NP_001264984                                                           16    7355
NP_001269519                                                           16    7355
NP_001269523                                                           16    7355
NP_001269520                                                           16    7355
NP_000822                                                              16    7355
NP_653316                                                              16    7355
XP_005266395                                                           16    7355
XP_005267003                                                           16    7355
XP_006715528                                                           16    7355
XP_005267002                                                           16    7355
XP_005264948                                                           16    7355
XP_005264946                                                           16    7355
XP_005245443                                                           16    7355
NP_001035203                                                           15    9605
NP_074035                                                              15    9605
NP_001035202                                                           15    9605
NP_002465                                                              15    9605
NP_612486                                                              15    9605
NP_001157281                                                           15    9605
NP_653319                                                              15    9605
NP_055844                                                              15    9605
NP_001139332                                                           15    9605
NP_775894                                                              15    9605
NP_001124390                                                           15    9605
NP_542394                                                              15    9605
NP_005638                                                              15    9605
NP_112494                                                              15    9605
XP_006725317                                                           15    9605
XP_006721892                                                           15    9605
XP_006721891                                                           15    9605
XP_006721890                                                           15    9605
XP_005256511                                                           15    9605
XP_005254235                                                           15    9605
XP_005254233                                                           15    9605
XP_005254234                                                           15    9605
XP_006713578                                                           15    9605
NP_001139333                                                           15    9605
NP_001132940                                                           15    9605
NP_001132938                                                           15    9605
NP_001132939                                                           15    9605
>NP_919047
          Length = 520

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NTNRTLLQR 9
           NTNRTLLQ+
Sbjct: 345 NTNRTLLQQ 353
>XP_005250598
          Length = 457

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NTNRTLLQR 9
           NTNRTLLQ+
Sbjct: 282 NTNRTLLQQ 290
>NP_443086
          Length = 519

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NTNRTLLQR 9
           N NRTLLQ+
Sbjct: 341 NANRTLLQQ 349
>NP_112572
          Length = 515

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           NT+RTLL+
Sbjct: 478 NTSRTLLE 485
>NP_705833
          Length = 2970

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TNRTLLQR 9
           +NRTL+QR
Sbjct: 416 SNRTLVQR 423
>XP_005247174
          Length = 2679

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TNRTLLQR 9
           +NRTL+QR
Sbjct: 125 SNRTLVQR 132
>NP_115766
          Length = 293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTNRTLLQR 9
           N NRTL Q+
Sbjct: 150 NRNRTLTQK 158
>NP_060862
          Length = 2104

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TNRTLLQR 9
            TNRTLL++
Sbjct: 1775 TNRTLLKQ 1782
>XP_005263172
          Length = 2104

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    TNRTLLQR 9
            TNRTLL++
Sbjct: 1775 TNRTLLKQ 1782
>NP_000005
          Length = 1474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NTNRTLLQR 9
            N NR LLQ+
Sbjct: 1294 NNNRLLLQQ 1302
>XP_006719119
          Length = 1512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NTNRTLLQR 9
            N NR LLQ+
Sbjct: 1294 NNNRLLLQQ 1302
>NP_001159719
          Length = 892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  NTNRTLL 7
          N NRTLL
Sbjct: 65 NRNRTLL 71
>NP_068775
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  NTNRTLL 7
          N NRTLL
Sbjct: 65 NRNRTLL 71
>NP_786944
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  NTNRTLL 7
          N NRTLL
Sbjct: 65 NRNRTLL 71
>NP_055178
          Length = 4579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NTNRTLLQ 8
            N N TLLQ
Sbjct: 1136 NKNHTLLQ 1143
>NP_001269524
          Length = 201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           +TNRT+L+
Sbjct: 155 HTNRTILK 162
>NP_067004
          Length = 335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           +TNRT+L+
Sbjct: 289 HTNRTILK 296
>NP_001269518
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           +TNRT+L+
Sbjct: 158 HTNRTILK 165
>NP_001264984
          Length = 4432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NTNRTLLQ 8
           N N TLLQ
Sbjct: 989 NKNHTLLQ 996
>NP_001269519
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           +TNRT+L+
Sbjct: 182 HTNRTILK 189
>NP_001269523
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           +TNRT+L+
Sbjct: 195 HTNRTILK 202
>NP_001269520
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           +TNRT+L+
Sbjct: 142 HTNRTILK 149
>NP_000822
          Length = 919

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  NTNRTLL 7
          N NRTLL
Sbjct: 68 NRNRTLL 74
>NP_653316
          Length = 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NTNRTLLQR 9
          N +RT++QR
Sbjct: 78 NISRTVMQR 86
>XP_005266395
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NTNRTLLQ 8
            N N TLLQ
Sbjct: 1145 NKNHTLLQ 1152
>XP_005267003
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  NTNRTLL 7
          N NRTLL
Sbjct: 16 NRNRTLL 22
>XP_006715528
          Length = 892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  NTNRTLL 7
          N NRTLL
Sbjct: 65 NRNRTLL 71
>XP_005267002
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  NTNRTLL 7
          N NRTLL
Sbjct: 65 NRNRTLL 71
>XP_005264948
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NTNRTLLQR 9
          N +RT++QR
Sbjct: 78 NISRTVMQR 86
>XP_005264946
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NTNRTLLQR 9
          N +RT++QR
Sbjct: 78 NISRTVMQR 86
>XP_005245443
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTNRTLLQ 8
           +TNRT+L+
Sbjct: 249 HTNRTILK 256
>NP_001035203
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NTNRTLLQR 9
            N NR  LQR
Sbjct: 1904 NANRRKLQR 1912
>NP_074035
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NTNRTLLQR 9
            N NR  LQR
Sbjct: 1897 NANRRKLQR 1905
>NP_001035202
          Length = 1945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NTNRTLLQR 9
            N NR  LQR
Sbjct: 1904 NANRRKLQR 1912
>NP_002465
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NTNRTLLQR 9
            N NR  LQR
Sbjct: 1897 NANRRKLQR 1905
>NP_612486
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLLQR 9
           RTLLQR
Sbjct: 677 RTLLQR 682
>NP_001157281
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RTLLQR 9
          RTLLQR
Sbjct: 88 RTLLQR 93
>NP_653319
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TNRTLLQR 9
           TN +L+QR
Sbjct: 658 TNESLIQR 665
>NP_055844
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TNRTLLQ 8
           TNR LLQ
Sbjct: 239 TNRCLLQ 245
>NP_001139332
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TNRTLLQ 8
           TNR LLQ
Sbjct: 239 TNRCLLQ 245
>NP_775894
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTNRTLLQ 8
           NTN TLL+
Sbjct: 450 NTNWTLLK 457
>NP_001124390
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTNRTLLQ 8
           NTN TLL+
Sbjct: 757 NTNWTLLK 764
>NP_542394
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TNRTLLQR 9
           T RTLLQ+
Sbjct: 275 TYRTLLQK 282
>NP_005638
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NTNRTLL 7
           NTN TLL
Sbjct: 297 NTNGTLL 303
>NP_112494
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTNRTLLQR 9
           N N+ +LQR
Sbjct: 791 NDNKDILQR 799
>XP_006725317
          Length = 1745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RTLLQR 9
          RTLLQR
Sbjct: 88 RTLLQR 93
>XP_006721892
          Length = 843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTNRTLLQ 8
           NTN TLL+
Sbjct: 709 NTNWTLLK 716
>XP_006721891
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTNRTLLQ 8
           NTN TLL+
Sbjct: 757 NTNWTLLK 764
>XP_006721890
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NTNRTLLQ 8
           NTN TLL+
Sbjct: 757 NTNWTLLK 764
>XP_005256511
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RTLLQR 9
          RTLLQR
Sbjct: 88 RTLLQR 93
>XP_005254235
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLLQR 9
           RTLLQR
Sbjct: 678 RTLLQR 683
>XP_005254233
          Length = 1228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLLQR 9
           RTLLQR
Sbjct: 678 RTLLQR 683
>XP_005254234
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLLQR 9
           RTLLQR
Sbjct: 678 RTLLQR 683
>XP_006713578
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TNRTLLQR 9
           TN +L+QR
Sbjct: 658 TNESLIQR 665
>NP_001139333
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TNRTLLQ 8
           TNR LLQ
Sbjct: 239 TNRCLLQ 245
>NP_001132940
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NTNRTLL 7
           NTN TLL
Sbjct: 246 NTNGTLL 252
>NP_001132938
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NTNRTLL 7
           NTN TLL
Sbjct: 297 NTNGTLL 303
>NP_001132939
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NTNRTLL 7
           NTN TLL
Sbjct: 246 NTNGTLL 252
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.125    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 500,880
Number of extensions: 1287
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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