Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              18    1135
XP_005253413                                                           16    5631
XP_005253412                                                           16    5631
NP_001635                                                              16    5631
NP_065831                                                              16    7355
NP_001122386                                                           15    9605
NP_001122383                                                           15    9605
NP_001122385                                                           15    9605
NP_005007                                                              15    9605
NP_001092090                                                           15    9605
NP_114366                                                              15    9605
NP_001122384                                                           15    9605
NP_001274745                                                           15    9605
NP_055662                                                              15    9605
NP_002536                                                              15    9605
NP_001012393                                                           15    9605
NP_006187                                                              15    9605
NP_001128625                                                           15    9605
NP_001123613                                                           15    9605
NP_065389                                                              15    9605
XP_005271636                                                           15    9605
XP_005271635                                                           15    9605
XP_005271632                                                           15    9605
XP_006718909                                                           15    9605
XP_005271631                                                           15    9605
XP_005273523                                                           15    9605
XP_006716387                                                           15    9605
XP_005273522                                                           15    9605
XP_005273521                                                           15    9605
XP_005273520                                                           15    9605
XP_006716386                                                           15    9605
XP_006711752                                                           15    9605
XP_006711751                                                           15    9605
XP_006711750                                                           15    9605
XP_006711749                                                           15    9605
XP_005245729                                                           15    9605
XP_005245727                                                           15    9605
XP_005245726                                                           15    9605
XP_005245725                                                           15    9605
XP_005245724                                                           15    9605
XP_005245715                                                           15    9605
XP_006711748                                                           15    9605
XP_006711747                                                           15    9605
XP_006711746                                                           15    9605
XP_006711745                                                           15    9605
XP_006711744                                                           15    9605
XP_006711743                                                           15    9605
XP_006711742                                                           15    9605
NP_001121903                                                           15    9605
NP_001128626                                                           15    9605
NP_056174                                                              15    9605
>NP_004110
          Length = 993

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TGVSIQVA 9
           TGVSIQVA
Sbjct: 635 TGVSIQVA 642
>XP_005253413
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NTGVSIQV 8
          N+GV+IQ+
Sbjct: 91 NSGVTIQI 98
>XP_005253412
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTGVSIQV 8
           N+GV+IQ+
Sbjct: 136 NSGVTIQI 143
>NP_001635
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NTGVSIQV 8
           N+GV+IQ+
Sbjct: 136 NSGVTIQI 143
>NP_065831
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    NTGVSI 6
            NTGVSI
Sbjct: 1325 NTGVSI 1330
>NP_001122386
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_001122383
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_001122385
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_005007
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_001092090
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_114366
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_001122384
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_001274745
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>NP_055662
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 966 NTGVSV 971
>NP_002536
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 231 NTGVSV 236
>NP_001012393
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 224 NTGVSV 229
>NP_006187
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 126 STGAQVQVA 134
>NP_001128625
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 390 NAGMSIQQA 398
>NP_001123613
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 158 STGAQVQVA 166
>NP_065389
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           +TG  +QVA
Sbjct: 158 STGAQVQVA 166
>XP_005271636
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  NTGVSI 6
          NTGVS+
Sbjct: 93 NTGVSV 98
>XP_005271635
          Length = 245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 131 NTGVSV 136
>XP_005271632
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 231 NTGVSV 236
>XP_006718909
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 223 NTGVSV 228
>XP_005271631
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 230 NTGVSV 235
>XP_005273523
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 390 NAGMSIQQA 398
>XP_006716387
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 390 NAGMSIQQA 398
>XP_005273522
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 390 NAGMSIQQA 398
>XP_005273521
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 400 NAGMSIQQA 408
>XP_005273520
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 400 NAGMSIQQA 408
>XP_006716386
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 400 NAGMSIQQA 408
>XP_006711752
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711751
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 626 NTGVSV 631
>XP_006711750
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 736 NTGVSV 741
>XP_006711749
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 771 NTGVSV 776
>XP_005245729
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_005245727
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245726
          Length = 1095

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245725
          Length = 1096

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245724
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245715
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711748
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711747
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711746
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711745
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711744
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711743
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711742
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTGVSI 6
           NTGVS+
Sbjct: 977 NTGVSV 982
>NP_001121903
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 390 NAGMSIQQA 398
>NP_001128626
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 390 NAGMSIQQA 398
>NP_056174
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTGVSIQVA 9
           N G+SIQ A
Sbjct: 390 NAGMSIQQA 398
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.120    0.298 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,446
Number of extensions: 507
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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