Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     665
NP_001263689                                                           19     665
NP_001119584                                                           19     665
NP_001119586                                                           19     665
NP_001263625                                                           19     665
NP_001119590                                                           19     665
NP_001263690                                                           19     665
NP_001119585                                                           19     665
NP_001263624                                                           19     665
NP_001119588                                                           19     665
NP_001119587                                                           19     665
NP_001119589                                                           19     665
NP_001263627                                                           19     665
NP_001263628                                                           19     665
NP_001263626                                                           19     665
NP_001137469                                                           17    4312
NP_001137468                                                           17    4312
NP_060715                                                              17    4312
NP_005804                                                              16    7355
NP_002696                                                              16    7355
NP_002733                                                              16    7355
NP_001073351                                                           16    7355
NP_001073350                                                           16    7355
NP_001073349                                                           16    7355
NP_057541                                                              16    7355
NP_001191443                                                           16    7355
XP_005258773                                                           16    7355
XP_006720965                                                           16    7355
XP_005267916                                                           16    7355
XP_006712043                                                           16    7355
XP_006712042                                                           16    7355
XP_006712041                                                           16    7355
XP_005264295                                                           16    7355
XP_005264294                                                           16    7355
NP_009052                                                              15    9605
NP_005968                                                              15    9605
NP_689417                                                              15    9605
NP_898865                                                              15    9605
NP_898864                                                              15    9605
NP_000520                                                              15    9605
XP_006720248                                                           15    9605
XP_005267848                                                           15    9605
XP_006719917                                                           15    9605
XP_005266543                                                           15    9605
XP_005266542                                                           15    9605
NP_060413                                                              15    9605
>NP_000537
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 210 NTFRHSVVV 218
>NP_001263689
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 171 NTFRHSVVV 179
>NP_001119584
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 210 NTFRHSVVV 218
>NP_001119586
          Length = 341

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 210 NTFRHSVVV 218
>NP_001263625
          Length = 302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 171 NTFRHSVVV 179
>NP_001119590
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 171 NTFRHSVVV 179
>NP_001263690
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 171 NTFRHSVVV 179
>NP_001119585
          Length = 346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 210 NTFRHSVVV 218
>NP_001263624
          Length = 307

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTFRRSVVV 9
           NTFR SVVV
Sbjct: 171 NTFRHSVVV 179
>NP_001119588
          Length = 209

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTFRRSVVV 9
          NTFR SVVV
Sbjct: 78 NTFRHSVVV 86
>NP_001119587
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTFRRSVVV 9
          NTFR SVVV
Sbjct: 78 NTFRHSVVV 86
>NP_001119589
          Length = 214

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTFRRSVVV 9
          NTFR SVVV
Sbjct: 78 NTFRHSVVV 86
>NP_001263627
          Length = 182

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTFRRSVVV 9
          NTFR SVVV
Sbjct: 51 NTFRHSVVV 59
>NP_001263628
          Length = 187

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTFRRSVVV 9
          NTFR SVVV
Sbjct: 51 NTFRHSVVV 59
>NP_001263626
          Length = 234

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTFRRSVVV 9
          NTFR SVVV
Sbjct: 51 NTFRHSVVV 59
>NP_001137469
          Length = 801

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTFRRSVVV 9
           NTF + VVV
Sbjct: 273 NTFNKDVVV 281
>NP_001137468
          Length = 953

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTFRRSVVV 9
           NTF + VVV
Sbjct: 425 NTFNKDVVV 433
>NP_060715
          Length = 1010

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTFRRSVVV 9
           NTF + VVV
Sbjct: 482 NTFNKDVVV 490
>NP_005804
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 731 SFRRSVV 737
>NP_002696
          Length = 1756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NTFRRSVVV 9
            N  RRS+VV
Sbjct: 1652 NHLRRSIVV 1660
>NP_002733
          Length = 912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 738 SFRRSVV 744
>NP_001073351
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 549 SFRRSVV 555
>NP_001073350
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_001073349
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_057541
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_001191443
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NTFRRSV 7
          NT+RRS+
Sbjct: 7  NTYRRSL 13
>XP_005258773
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 549 SFRRSVV 555
>XP_006720965
          Length = 1769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NTFRRSVVV 9
            N  RRS+VV
Sbjct: 1665 NHLRRSIVV 1673
>XP_005267916
          Length = 920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 746 SFRRSVV 752
>XP_006712043
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 472 SFRRSVV 478
>XP_006712042
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 558 SFRRSVV 564
>XP_006712041
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 558 SFRRSVV 564
>XP_005264295
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 627 SFRRSVV 633
>XP_005264294
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TFRRSVV 8
           +FRRSVV
Sbjct: 731 SFRRSVV 737
>NP_009052
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FRRSVV 8
           FRRSVV
Sbjct: 111 FRRSVV 116
>NP_005968
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTFRRS 6
           NTFRR+
Sbjct: 115 NTFRRT 120
>NP_689417
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTFRRSV 7
           N+FRR+V
Sbjct: 306 NSFRRNV 312
>NP_898865
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTFRRS 6
           NTFRR+
Sbjct: 115 NTFRRT 120
>NP_898864
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTFRRS 6
           NTFRR+
Sbjct: 115 NTFRRT 120
>NP_000520
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TFRRSVVV 9
           T RR+VVV
Sbjct: 143 TMRRTVVV 150
>XP_006720248
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTFRRSV 7
           N+FRR+V
Sbjct: 306 NSFRRNV 312
>XP_005267848
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTFRRSV 7
           N+FRR+V
Sbjct: 306 NSFRRNV 312
>XP_006719917
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTFRRS 6
           NTFRR+
Sbjct: 115 NTFRRT 120
>XP_005266543
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTFRRS 6
           NTFRR+
Sbjct: 115 NTFRRT 120
>XP_005266542
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTFRRS 6
           NTFRR+
Sbjct: 115 NTFRRT 120
>NP_060413
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTFRRSV 7
           N+FRR+V
Sbjct: 306 NSFRRNV 312
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.137    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 384,863
Number of extensions: 613
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package