Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              21     229
NP_005913                                                              21     229
XP_005267046                                                           21     229
XP_005267045                                                           21     229
NP_075044                                                              17    4312
NP_060484                                                              17    4312
NP_001923                                                              17    4312
XP_006721980                                                           17    4312
XP_006721978                                                           17    4312
NP_001013421                                                           16    5631
NP_001092286                                                           16    5631
XP_006718561                                                           16    5631
NP_690867                                                              16    5631
NP_006026                                                              16    7355
NP_006724                                                              16    7355
NP_076962                                                              16    7355
NP_059129                                                              16    7355
XP_005262168                                                           16    7355
XP_005268287                                                           16    7355
XP_005268286                                                           16    7355
XP_005268285                                                           16    7355
XP_005268284                                                           16    7355
XP_005269201                                                           16    7355
NP_115976                                                              16    7355
NP_005076                                                              15    9605
NP_001193698                                                           15    9605
NP_001273206                                                           15    9605
NP_002429                                                              15    9605
NP_066943                                                              15    9605
NP_001136171                                                           15    9605
NP_001136174                                                           15    9605
NP_001136172                                                           15    9605
NP_001273207                                                           15    9605
NP_001273208                                                           15    9605
NP_001073944                                                           15    9605
NP_006313                                                              15    9605
NP_937839                                                              15    9605
NP_059344                                                              15    9605
NP_060862                                                              15    9605
NP_006331                                                              15    9605
NP_059345                                                              15    9605
NP_065781                                                              15    9605
XP_005262305                                                           15    9605
XP_006724689                                                           15    9605
XP_006724688                                                           15    9605
XP_005257005                                                           15    9605
XP_006721700                                                           15    9605
XP_005268350                                                           15    9605
XP_006718502                                                           15    9605
XP_005273868                                                           15    9605
XP_006718501                                                           15    9605
XP_005273867                                                           15    9605
XP_005273866                                                           15    9605
XP_005273864                                                           15    9605
XP_005273863                                                           15    9605
XP_005273862                                                           15    9605
XP_005272276                                                           15    9605
XP_005272275                                                           15    9605
XP_006717355                                                           15    9605
XP_005272274                                                           15    9605
XP_005272273                                                           15    9605
XP_005263172                                                           15    9605
XP_005247120                                                           15    9605
XP_006713533                                                           15    9605
XP_006713532                                                           15    9605
XP_005246602                                                           15    9605
XP_006712584                                                           15    9605
XP_005246601                                                           15    9605
XP_005246600                                                           15    9605
NP_001159750                                                           15    9605
NP_001355                                                              15    9605
NP_001138360                                                           15    9605
NP_005807                                                              15    9605
NP_060947                                                              15    9605
>NP_006715
          Length = 1558

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTENLYATS 9
          NTENLY TS
Sbjct: 76 NTENLYGTS 84
>NP_005913
          Length = 1608

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTENLYATS 9
          NTENLY TS
Sbjct: 76 NTENLYGTS 84
>XP_005267046
          Length = 1554

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTENLYATS 9
          NTENLY TS
Sbjct: 76 NTENLYGTS 84
>XP_005267045
          Length = 1604

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NTENLYATS 9
          NTENLY TS
Sbjct: 76 NTENLYGTS 84
>NP_075044
          Length = 835

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTENLYA 7
           NTEN+Y+
Sbjct: 651 NTENVYS 657
>NP_060484
          Length = 773

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NTENLYA 7
           NTEN+Y+
Sbjct: 651 NTENVYS 657
>NP_001923
          Length = 585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           ENLY TS
Sbjct: 459 ENLYGTS 465
>XP_006721980
          Length = 383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           ENLY TS
Sbjct: 257 ENLYGTS 263
>XP_006721978
          Length = 585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           ENLY TS
Sbjct: 459 ENLYGTS 465
>NP_001013421
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NTENLYATS 9
           NT+NL+ +S
Sbjct: 293 NTQNLHVSS 301
>NP_001092286
          Length = 2769

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    NTENLYATS 9
            NT+N+Y  S
Sbjct: 1571 NTQNMYELS 1579
>XP_006718561
          Length = 2794

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    NTENLYATS 9
            NT+N+Y  S
Sbjct: 1596 NTQNMYELS 1604
>NP_690867
          Length = 674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NTENLYATS 9
           N E LYA S
Sbjct: 140 NVERLYAAS 148
>NP_006026
          Length = 1711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NTENLYA 7
           NTE +YA
Sbjct: 97  NTERIYA 103
>NP_006724
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NTENLYATS 9
           N+ENL+ T+
Sbjct: 264 NSENLWKTA 272
>NP_076962
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TENLYATS 9
           +ENL+AT+
Sbjct: 263 SENLFATT 270
>NP_059129
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NTENLYA 7
            NT NLY+
Sbjct: 1389 NTHNLYS 1395
>XP_005262168
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NTENLYATS 9
           N+ENL+ T+
Sbjct: 264 NSENLWKTA 272
>XP_005268287
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NTENLYA 7
           NTE +YA
Sbjct: 97  NTERIYA 103
>XP_005268286
          Length = 1685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NTENLYA 7
           NTE +YA
Sbjct: 97  NTERIYA 103
>XP_005268285
          Length = 1702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NTENLYA 7
           NTE +YA
Sbjct: 97  NTERIYA 103
>XP_005268284
          Length = 1728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NTENLYA 7
           NTE +YA
Sbjct: 97  NTERIYA 103
>XP_005269201
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TENLYATS 9
           +ENL+AT+
Sbjct: 263 SENLFATT 270
>NP_115976
          Length = 1037

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NTENLYAT 8
           N +NLY T
Sbjct: 714 NLQNLYGT 721
>NP_005076
          Length = 2090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NTENLYATS 9
            NT NL+  S
Sbjct: 1917 NTSNLFGNS 1925
>NP_001193698
          Length = 909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 791 DNLYGTS 797
>NP_001273206
          Length = 897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NTENLY 6
           NTEN Y
Sbjct: 260 NTENCY 265
>NP_002429
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NTENLYATS 9
           N EN Y T+
Sbjct: 533 NNENAYLTT 541
>NP_066943
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 699 DNLYGTS 705
>NP_001136171
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 857 DNLYGTS 863
>NP_001136174
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 216 DNLYGTS 222
>NP_001136172
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 631 DNLYGTS 637
>NP_001273207
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NTENLY 6
           NTEN Y
Sbjct: 270 NTENCY 275
>NP_001273208
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NTENLY 6
           NTEN Y
Sbjct: 270 NTENCY 275
>NP_001073944
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ENLYAT 8
           +NLYAT
Sbjct: 251 QNLYAT 256
>NP_006313
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NTENLY 6
           NTEN Y
Sbjct: 270 NTENCY 275
>NP_937839
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  ENLYAT 8
          EN+YAT
Sbjct: 31 ENVYAT 36
>NP_059344
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TENLYAT 8
          TEN+Y T
Sbjct: 13 TENVYKT 19
>NP_060862
          Length = 2104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTENLY 6
           +TENLY
Sbjct: 307 STENLY 312
>NP_006331
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TENLYAT 8
          TEN+Y T
Sbjct: 13 TENVYKT 19
>NP_059345
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TENLYAT 8
          TEN+Y T
Sbjct: 13 TENVYKT 19
>NP_065781
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 394 DNLYGTS 400
>XP_005262305
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 248 DNLYGTS 254
>XP_006724689
          Length = 831

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 713 DNLYGTS 719
>XP_006724688
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 731 DNLYGTS 737
>XP_005257005
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TENLYAT 8
          TEN+Y T
Sbjct: 13 TENVYKT 19
>XP_006721700
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TENLYAT 8
          TEN+Y T
Sbjct: 13 TENVYKT 19
>XP_005268350
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   NTENLY 6
           NTEN Y
Sbjct: 270 NTENCY 275
>XP_006718502
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 625 DNLYGTS 631
>XP_005273868
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 701 DNLYGTS 707
>XP_006718501
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 710 DNLYGTS 716
>XP_005273867
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 719 DNLYGTS 725
>XP_005273866
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 734 DNLYGTS 740
>XP_005273864
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 754 DNLYGTS 760
>XP_005273863
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 772 DNLYGTS 778
>XP_005273862
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 773 DNLYGTS 779
>XP_005272276
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NTENLYATS 9
            NT NL+  S
Sbjct: 1863 NTSNLFGNS 1871
>XP_005272275
          Length = 2083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NTENLYATS 9
            NT NL+  S
Sbjct: 1910 NTSNLFGNS 1918
>XP_006717355
          Length = 2120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NTENLYATS 9
            NT NL+  S
Sbjct: 1947 NTSNLFGNS 1955
>XP_005272274
          Length = 2121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NTENLYATS 9
            NT NL+  S
Sbjct: 1948 NTSNLFGNS 1956
>XP_005272273
          Length = 2132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NTENLYATS 9
            NT NL+  S
Sbjct: 1959 NTSNLFGNS 1967
>XP_005263172
          Length = 2104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTENLY 6
           +TENLY
Sbjct: 307 STENLY 312
>XP_005247120
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  ENLYAT 8
          EN+YAT
Sbjct: 31 ENVYAT 36
>XP_006713533
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  ENLYAT 8
          EN+YAT
Sbjct: 31 ENVYAT 36
>XP_006713532
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  ENLYAT 8
          EN+YAT
Sbjct: 31 ENVYAT 36
>XP_005246602
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ENLYAT 8
           +NLYAT
Sbjct: 251 QNLYAT 256
>XP_006712584
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ENLYAT 8
           +NLYAT
Sbjct: 251 QNLYAT 256
>XP_005246601
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ENLYAT 8
           +NLYAT
Sbjct: 251 QNLYAT 256
>XP_005246600
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ENLYAT 8
           +NLYAT
Sbjct: 251 QNLYAT 256
>NP_001159750
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 248 DNLYGTS 254
>NP_001355
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ENLYATS 9
           +NLY TS
Sbjct: 752 DNLYGTS 758
>NP_001138360
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TENLYAT 8
          TEN+Y T
Sbjct: 13 TENVYKT 19
>NP_005807
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  ENLYAT 8
          EN+YAT
Sbjct: 31 ENVYAT 36
>NP_060947
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NTENLYA 7
          NTE LY+
Sbjct: 60 NTEELYS 66
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.291    0.106    0.266 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 508,173
Number of extensions: 780
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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