Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              19     665
NP_689599                                                              17    4312
XP_005246354                                                           17    4312
NP_001032208                                                           15    9605
NP_055729                                                              15    9605
XP_006716244                                                           15    9605
XP_005250774                                                           15    9605
XP_006712302                                                           15    9605
XP_006712301                                                           15    9605
XP_006712300                                                           15    9605
XP_005246116                                                           15    9605
XP_006712299                                                           15    9605
XP_005246115                                                           15    9605
XP_006712298                                                           15    9605
XP_006712297                                                           15    9605
NP_004270                                                              15    9605

>NP_004351
          Length = 882

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NTAIAYTIL 9
           N AIAYTIL
Sbjct: 297 NAAIAYTIL 305



>NP_689599
          Length = 399

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TAIAYTIL 9
           TAIA+T+L
Sbjct: 171 TAIAFTLL 178



>XP_005246354
          Length = 271

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  TAIAYTIL 9
          TAIA+T+L
Sbjct: 43 TAIAFTLL 50



>NP_001032208
          Length = 857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 803 NTALAY 808



>NP_055729
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 750 NTALAY 755



>XP_006716244
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTAIAYTIL 9
           NTA+  TIL
Sbjct: 204 NTALGRTIL 212



>XP_005250774
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTAIAYTIL 9
           NTA+  TIL
Sbjct: 204 NTALGRTIL 212



>XP_006712302
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 728 NTALAY 733



>XP_006712301
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 694 NTALAY 699



>XP_006712300
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 694 NTALAY 699



>XP_005246116
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 754 NTALAY 759



>XP_006712299
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 779 NTALAY 784



>XP_005246115
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 807 NTALAY 812



>XP_006712298
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 828 NTALAY 833



>XP_006712297
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NTAIAY 6
           NTA+AY
Sbjct: 832 NTALAY 837



>NP_004270
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NTAIAYTIL 9
           NTA+  TIL
Sbjct: 204 NTALGRTIL 212



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.131    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 345,099
Number of extensions: 512
Number of successful extensions: 16
Number of sequences better than 10000.0: 16
Number of HSP's gapped: 16
Number of HSP's successfully gapped: 16
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)