Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001121619                                                           18    1135
NP_000258                                                              18    1135
NP_001035957                                                           18    1135
XP_006721991                                                           18    1135
XP_006721990                                                           18    1135
XP_006721989                                                           18    1135
XP_005258041                                                           18    1135
XP_006721988                                                           18    1135
XP_006721987                                                           18    1135
XP_006721986                                                           18    1135
XP_005258040                                                           18    1135
XP_006721985                                                           18    1135
NP_001004731                                                           18    1935
NP_004806                                                              17    3301
XP_006711111                                                           17    3301
NP_001004696                                                           17    3301
NP_001004697                                                           17    3301
NP_001004694                                                           17    3301
NP_001136239                                                           17    4312
NP_001136238                                                           17    4312
NP_149045                                                              17    4312
XP_005273174                                                           17    4312
NP_004203                                                              17    4312
NP_001005522                                                           17    4312
NP_001004695                                                           17    4312
NP_001269356                                                           16    5631
NP_001269355                                                           16    5631
NP_002640                                                              16    5631
XP_006716090                                                           16    5631
XP_005250500                                                           16    5631
XP_006711828                                                           16    7355
XP_006711827                                                           16    7355
XP_006711826                                                           16    7355
NP_001001966                                                           16    7355
NP_001004759                                                           16    7355
NP_000541                                                              15    9605
NP_079239                                                              15    9605
NP_056041                                                              15    9605
NP_114072                                                              15    9605
NP_009145                                                              15    9605
NP_777562                                                              15    9605
NP_006134                                                              15    9605
NP_001230332                                                           15    9605
XP_006726822                                                           15    9605
XP_006725444                                                           15    9605
XP_005276974                                                           15    9605
XP_006722328                                                           15    9605
XP_006721523                                                           15    9605
XP_006720933                                                           15    9605
XP_005255273                                                           15    9605
XP_005255272                                                           15    9605
XP_005255271                                                           15    9605
XP_005255270                                                           15    9605
XP_005255268                                                           15    9605
XP_005255267                                                           15    9605
XP_005251631                                                           15    9605
NP_001026976                                                           15    9605
>NP_001121619
          Length = 593

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>NP_000258
          Length = 2818

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>NP_001035957
          Length = 2839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_006721991
          Length = 1632

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_006721990
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_006721989
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_005258041
          Length = 2836

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_006721988
          Length = 2846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_006721987
          Length = 2849

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_006721986
          Length = 2854

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 326 NSVIFLLV 333
>XP_005258040
          Length = 2857

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>XP_006721985
          Length = 2867

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           NSVIFLLV
Sbjct: 339 NSVIFLLV 346
>NP_001004731
          Length = 362

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           N V+FLL+H
Sbjct: 93  NLVMFLLIH 101
>NP_004806
          Length = 1261

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           NS+ FL+VH
Sbjct: 816 NSLHFLIVH 824
>XP_006711111
          Length = 1197

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           NS+ FL+VH
Sbjct: 752 NSLHFLIVH 760
>NP_001004696
          Length = 348

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NSVIFLLVH 9
          N+V+ LL+H
Sbjct: 74 NAVLILLIH 82
>NP_001004697
          Length = 315

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NSVIFLLVH 9
          N+V+ LL+H
Sbjct: 46 NAVLILLIH 54
>NP_001004694
          Length = 315

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NSVIFLLVH 9
          N+V+ LL+H
Sbjct: 46 NAVLILLIH 54
>NP_001136239
          Length = 1915

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSVIFLLVH 9
            +S++FLL H
Sbjct: 1414 SSILFLLYH 1422
>NP_001136238
          Length = 1952

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSVIFLLVH 9
            +S++FLL H
Sbjct: 1451 SSILFLLYH 1459
>NP_149045
          Length = 1955

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSVIFLLVH 9
            +S++FLL H
Sbjct: 1454 SSILFLLYH 1462
>XP_005273174
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NSVIFLLVH 9
          NS++ LL+H
Sbjct: 40 NSLMILLIH 48
>NP_004203
          Length = 658

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VIFLLVH 9
           VIF+LVH
Sbjct: 114 VIFVLVH 120
>NP_001005522
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NSVIFLLVH 9
          NS++ LL+H
Sbjct: 40 NSLMILLIH 48
>NP_001004695
          Length = 320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NSVIFLLVH 9
          NS++ LL+H
Sbjct: 40 NSLMILLIH 48
>NP_001269356
          Length = 1102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           N+ IF+++H
Sbjct: 217 NNCIFIVIH 225
>NP_001269355
          Length = 1102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           N+ IF+++H
Sbjct: 217 NNCIFIVIH 225
>NP_002640
          Length = 1102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           N+ IF+++H
Sbjct: 217 NNCIFIVIH 225
>XP_006716090
          Length = 878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           N+ IF+++H
Sbjct: 217 NNCIFIVIH 225
>XP_005250500
          Length = 1102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           N+ IF+++H
Sbjct: 217 NNCIFIVIH 225
>XP_006711828
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  NSVIFLLVH 9
          +S++FLL++
Sbjct: 48 HSILFLLIY 56
>XP_006711827
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  NSVIFLLVH 9
          +S++FLL++
Sbjct: 25 HSILFLLIY 33
>XP_006711826
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  NSVIFLLVH 9
          +S++FLL++
Sbjct: 48 HSILFLLIY 56
>NP_001001966
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  NSVIFLLVH 9
          +S++FLL++
Sbjct: 25 HSILFLLIY 33
>NP_001004759
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NSVIFLLV 8
          NS+IFL++
Sbjct: 71 NSMIFLVI 78
>NP_000541
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSVIFLLVH 9
           N  IF+L+H
Sbjct: 396 NDPIFVLLH 404
>NP_079239
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVIFLLVH 9
           N VIF L+H
Sbjct: 676 NVVIFPLLH 684
>NP_056041
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 318 SQVFLIIH 325
>NP_114072
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SVIFLLVH 9
           +V+FLLV+
Sbjct: 397 TVVFLLVY 404
>NP_009145
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSVIFLLVH 9
           NS++ LLV+
Sbjct: 188 NSILVLLVY 196
>NP_777562
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NSVIFLLV 8
           +SVIF+LV
Sbjct: 179 SSVIFVLV 186
>NP_006134
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  NSVIFLLVH 9
          NS++ L++H
Sbjct: 83 NSLVCLVIH 91
>NP_001230332
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 316 SQVFLIIH 323
>XP_006726822
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSVIFLLVH 9
           N  IF+L+H
Sbjct: 294 NIFIFILLH 302
>XP_006725444
          Length = 232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSVIFLLVH 9
           N  IF+L+H
Sbjct: 219 NIFIFILLH 227
>XP_005276974
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSVIFLLVH 9
           N  IF+L+H
Sbjct: 280 NIFIFILLH 288
>XP_006722328
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSVIFLLVH 9
           N  IF+L+H
Sbjct: 294 NIFIFILLH 302
>XP_006721523
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  SVIFLLV 8
          SV+FLLV
Sbjct: 31 SVLFLLV 37
>XP_006720933
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 318 SQVFLIIH 325
>XP_005255273
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 318 SQVFLIIH 325
>XP_005255272
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 318 SQVFLIIH 325
>XP_005255271
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 318 SQVFLIIH 325
>XP_005255270
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 316 SQVFLIIH 323
>XP_005255268
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 318 SQVFLIIH 325
>XP_005255267
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SVIFLLVH 9
           S +FL++H
Sbjct: 316 SQVFLIIH 323
>XP_005251631
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSVIFLLVH 9
           N  IF+L+H
Sbjct: 396 NDPIFVLLH 404
>NP_001026976
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VIFLLVH 9
           +IFL+VH
Sbjct: 493 LIFLVVH 499
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.152    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 391,772
Number of extensions: 731
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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