Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              20     509
XP_005267290                                                           20     509
NP_001275918                                                           17    4312
NP_057425                                                              17    4312
XP_006717952                                                           17    4312
XP_006717951                                                           17    4312
XP_006717950                                                           17    4312
XP_006717949                                                           17    4312
XP_006717948                                                           17    4312
NP_001012660                                                           17    4312
NP_061885                                                              16    7355
NP_001137378                                                           16    7355
NP_006691                                                              16    7355
NP_001243716                                                           16    7355
NP_001243399                                                           16    7355
NP_001137293                                                           16    7355
NP_065145                                                              16    7355
NP_055792                                                              16    7355
NP_001158287                                                           16    7355
NP_001158286                                                           16    7355
NP_001456                                                              16    7355
NP_955367                                                              16    7355
NP_001158288                                                           16    7355
NP_001158289                                                           16    7355
NP_068834                                                              16    7355
NP_569712                                                              16    7355
NP_085059                                                              16    7355
NP_001230022                                                           16    7355
XP_005267475                                                           16    7355
XP_005267473                                                           16    7355
XP_005267472                                                           16    7355
XP_006719159                                                           16    7355
XP_006719157                                                           16    7355
XP_006719156                                                           16    7355
XP_006719155                                                           16    7355
XP_005253457                                                           16    7355
XP_006719154                                                           16    7355
XP_005253456                                                           16    7355
XP_005253455                                                           16    7355
XP_006719153                                                           16    7355
XP_006719152                                                           16    7355
XP_006714529                                                           16    7355
XP_006714528                                                           16    7355
XP_006714527                                                           16    7355
NP_001164263                                                           15    9605
NP_001164262                                                           15    9605
NP_001129599                                                           15    9605
NP_056150                                                              15    9605
NP_055907                                                              15    9605
NP_001271226                                                           15    9605
NP_001039                                                              15    9605
NP_001271227                                                           15    9605
XP_006726695                                                           15    9605
XP_005255242                                                           15    9605
XP_005255241                                                           15    9605
XP_005255240                                                           15    9605
XP_005255239                                                           15    9605
XP_005254507                                                           15    9605
XP_005254506                                                           15    9605
XP_005254505                                                           15    9605
XP_006720635                                                           15    9605
XP_006720634                                                           15    9605
XP_006719370                                                           15    9605
XP_006719369                                                           15    9605
XP_006719368                                                           15    9605
XP_005264218                                                           15    9605
XP_005245137                                                           15    9605
NP_004564                                                              15    9605
>NP_005091
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NSVAEQDEL 9
          N VAEQDEL
Sbjct: 66 NGVAEQDEL 74
>XP_005267290
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NSVAEQDEL 9
          N VAEQDEL
Sbjct: 66 NGVAEQDEL 74
>NP_001275918
          Length = 2286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           NSVAE+D
Sbjct: 127 NSVAEED 133
>NP_057425
          Length = 2302

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717952
          Length = 2300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717951
          Length = 2315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717950
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717949
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717948
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           NSVAE+D
Sbjct: 127 NSVAEED 133
>NP_001012660
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NSVAEQDEL 9
           N+V E+DEL
Sbjct: 287 NAVYEEDEL 295
>NP_061885
          Length = 1116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1059 NSVDEQEE 1066
>NP_001137378
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           +SVAEQD
Sbjct: 255 SSVAEQD 261
>NP_006691
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NSVAEQD 7
           +SVAEQD
Sbjct: 255 SSVAEQD 261
>NP_001243716
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1041 NSVDEQEE 1048
>NP_001243399
          Length = 1282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1225 NSVDEQEE 1232
>NP_001137293
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1117 NSVDEQEE 1124
>NP_065145
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEQDEL 9
           AEQDEL
Sbjct: 183 AEQDEL 188
>NP_055792
          Length = 1341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    AEQDEL 9
            AEQDEL
Sbjct: 1087 AEQDEL 1092
>NP_001158287
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    AEQDEL 9
            AEQDEL
Sbjct: 1047 AEQDEL 1052
>NP_001158286
          Length = 1328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    AEQDEL 9
            AEQDEL
Sbjct: 1074 AEQDEL 1079
>NP_001456
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSVAEQDEL 9
           + VAEQD++
Sbjct: 596 DDVAEQDDI 604
>NP_955367
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSVAEQDEL 9
           + VAEQD++
Sbjct: 596 DDVAEQDDI 604
>NP_001158288
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEQDEL 9
           AEQDEL
Sbjct: 360 AEQDEL 365
>NP_001158289
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEQDEL 9
           AEQDEL
Sbjct: 329 AEQDEL 334
>NP_068834
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VAEQDEL 9
          VAEQD+L
Sbjct: 69 VAEQDKL 75
>NP_569712
          Length = 1336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VAEQDEL 9
            VAEQ+EL
Sbjct: 1051 VAEQEEL 1057
>NP_085059
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VAEQDEL 9
            VAEQ+EL
Sbjct: 1231 VAEQEEL 1237
>NP_001230022
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSVAEQDEL 9
           + VAEQD++
Sbjct: 606 DDVAEQDDI 614
>XP_005267475
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEQDEL 9
           AEQDEL
Sbjct: 329 AEQDEL 334
>XP_005267473
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    AEQDEL 9
            AEQDEL
Sbjct: 1075 AEQDEL 1080
>XP_005267472
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    AEQDEL 9
            AEQDEL
Sbjct: 1086 AEQDEL 1091
>XP_006719159
          Length = 1276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1219 NSVDEQEE 1226
>XP_006719157
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1071 NSVDEQEE 1078
>XP_006719156
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1094 NSVDEQEE 1101
>XP_006719155
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1116 NSVDEQEE 1123
>XP_005253457
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1122 NSVDEQEE 1129
>XP_006719154
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1140 NSVDEQEE 1147
>XP_005253456
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1149 NSVDEQEE 1156
>XP_005253455
          Length = 1218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1161 NSVDEQEE 1168
>XP_006719153
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1167 NSVDEQEE 1174
>XP_006719152
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSV EQ+E
Sbjct: 1179 NSVDEQEE 1186
>XP_006714529
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSVAEQDEL 9
           + VAEQD++
Sbjct: 596 DDVAEQDDI 604
>XP_006714528
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSVAEQDEL 9
           + VAEQD++
Sbjct: 596 DDVAEQDDI 604
>XP_006714527
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSVAEQDEL 9
           + VAEQD++
Sbjct: 596 DDVAEQDDI 604
>NP_001164263
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  NSVAEQDEL 9
          NS+  QDE+
Sbjct: 50 NSITLQDEI 58
>NP_001164262
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  NSVAEQDEL 9
          NS+  QDE+
Sbjct: 50 NSITLQDEI 58
>NP_001129599
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SVAEQDE 8
           SVAE DE
Sbjct: 626 SVAENDE 632
>NP_056150
          Length = 2210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SVAEQDEL 9
            SVA+ DEL
Sbjct: 2137 SVAQTDEL 2144
>NP_055907
          Length = 3661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSVA+Q E
Sbjct: 1108 NSVAQQAE 1115
>NP_001271226
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
>NP_001039
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  NSVAEQDEL 9
          +  AEQDE+
Sbjct: 74 SQAAEQDEM 82
>NP_001271227
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
>XP_006726695
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NSVAEQDE 8
           NSVA+Q E
Sbjct: 623 NSVAQQAE 630
>XP_005255242
          Length = 3609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSVA+Q E
Sbjct: 1056 NSVAQQAE 1063
>XP_005255241
          Length = 3637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSVA+Q E
Sbjct: 1056 NSVAQQAE 1063
>XP_005255240
          Length = 3663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSVA+Q E
Sbjct: 1082 NSVAQQAE 1089
>XP_005255239
          Length = 3689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NSVAEQDE 8
            NSVA+Q E
Sbjct: 1108 NSVAQQAE 1115
>XP_005254507
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
>XP_005254506
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
>XP_005254505
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
>XP_006720635
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
>XP_006720634
          Length = 1184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
>XP_006719370
          Length = 2076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SVAEQDEL 9
            SVA+ DEL
Sbjct: 2003 SVAQTDEL 2010
>XP_006719369
          Length = 2200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SVAEQDEL 9
            SVA+ DEL
Sbjct: 2127 SVAQTDEL 2134
>XP_006719368
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SVAEQDEL 9
            SVA+ DEL
Sbjct: 2136 SVAQTDEL 2143
>XP_005264218
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  NSVAEQDEL 9
          NS+  QDE+
Sbjct: 50 NSITLQDEI 58
>XP_005245137
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SVAEQDE 8
           SVAE DE
Sbjct: 636 SVAENDE 642
>NP_004564
          Length = 1185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NSVAEQDEL 9
           NSV  QD+L
Sbjct: 300 NSVLAQDKL 308
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.288    0.111    0.255 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 559,598
Number of extensions: 754
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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