Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           21     175
NP_858045                                                              21     175
NP_006525                                                              21     175
NP_001167559                                                           21     175
NP_071347                                                              17    3301
XP_006713348                                                           17    3301
NP_573439                                                              17    4312
NP_573438                                                              17    4312
NP_001181930                                                           17    4312
NP_005695                                                              17    4312
NP_115871                                                              17    4312
XP_006722986                                                           17    4312
XP_005259717                                                           17    4312
XP_005259716                                                           17    4312
XP_006710336                                                           17    4312
XP_006710335                                                           17    4312
XP_006710334                                                           17    4312
XP_006710333                                                           17    4312
XP_006710332                                                           17    4312
NP_036441                                                              16    5631
NP_573573                                                              16    5631
XP_005277989                                                           16    5631
XP_006718541                                                           16    5631
XP_006718540                                                           16    5631
XP_005277987                                                           16    5631
NP_077017                                                              16    5631
NP_006337                                                              16    7355
XP_006719819                                                           16    7355
NP_002309                                                              15    9605
NP_542388                                                              15    9605
NP_055950                                                              15    9605
NP_055797                                                              15    9605
XP_005267486                                                           15    9605
XP_006720145                                                           15    9605
XP_005267485                                                           15    9605
XP_005267483                                                           15    9605
XP_005267482                                                           15    9605
XP_005267481                                                           15    9605
XP_005267480                                                           15    9605
XP_005267479                                                           15    9605
XP_005267478                                                           15    9605
XP_005267477                                                           15    9605
XP_005250292                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NSMINQMNQ 9
            NSM+NQMNQ
Sbjct: 1136 NSMMNQMNQ 1144
>NP_858045
          Length = 1424

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NSMINQMNQ 9
            NSM+NQMNQ
Sbjct: 1136 NSMMNQMNQ 1144
>NP_006525
          Length = 1420

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NSMINQMNQ 9
            NSM+NQMNQ
Sbjct: 1136 NSMMNQMNQ 1144
>NP_001167559
          Length = 1415

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NSMINQMNQ 9
            NSM+NQMNQ
Sbjct: 1131 NSMMNQMNQ 1139
>NP_071347
          Length = 1314

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NSMINQMN 8
            NS++NQ+N
Sbjct: 1031 NSVLNQLN 1038
>XP_006713348
          Length = 1314

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NSMINQMN 8
            NS++NQ+N
Sbjct: 1031 NSVLNQLN 1038
>NP_573439
          Length = 1436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1265 MLNQLNQ 1271
>NP_573438
          Length = 1440

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1271 MLNQLNQ 1277
>NP_001181930
          Length = 1433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1262 MLNQLNQ 1268
>NP_005695
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1275 MLNQLNQ 1281
>NP_115871
          Length = 1537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NSM++ +NQ
Sbjct: 1128 NSMVSNINQ 1136
>XP_006722986
          Length = 1519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSMINQMNQ 9
           NSM++ +NQ
Sbjct: 909 NSMVSNINQ 917
>XP_005259717
          Length = 1738

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NSM++ +NQ
Sbjct: 1128 NSMVSNINQ 1136
>XP_005259716
          Length = 1738

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NSM++ +NQ
Sbjct: 1128 NSMVSNINQ 1136
>XP_006710336
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1006 MLNQLNQ 1012
>XP_006710335
          Length = 1370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1199 MLNQLNQ 1205
>XP_006710334
          Length = 1292

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1121 MLNQLNQ 1127
>XP_006710333
          Length = 1439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1268 MLNQLNQ 1274
>XP_006710332
          Length = 1442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MINQMNQ 9
            M+NQ+NQ
Sbjct: 1271 MLNQLNQ 1277
>NP_036441
          Length = 1849

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NS++ QMN+
Sbjct: 1628 NSILQQMNR 1636
>NP_573573
          Length = 1261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NS++ QMN+
Sbjct: 1040 NSILQQMNR 1048
>XP_005277989
          Length = 1470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NS++ QMN+
Sbjct: 1249 NSILQQMNR 1257
>XP_006718541
          Length = 1839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NS++ QMN+
Sbjct: 1618 NSILQQMNR 1626
>XP_006718540
          Length = 1842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NS++ QMN+
Sbjct: 1621 NSILQQMNR 1629
>XP_005277987
          Length = 1849

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NSMINQMNQ 9
            NS++ QMN+
Sbjct: 1628 NSILQQMNR 1636
>NP_077017
          Length = 83

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NSMINQMN 8
          NSM++Q+N
Sbjct: 32 NSMLDQIN 39
>NP_006337
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSMINQMNQ 9
           NS++NQ  Q
Sbjct: 616 NSLLNQTQQ 624
>XP_006719819
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSMINQMNQ 9
           NS++NQ  Q
Sbjct: 191 NSLLNQTQQ 199
>NP_002309
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NSMINQM 7
           NS+INQ+
Sbjct: 170 NSLINQI 176
>NP_542388
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NSMINQMN 8
           NS+IN+ N
Sbjct: 221 NSVINRFN 228
>NP_055950
          Length = 2012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SMINQMN 8
            SM+NQM+
Sbjct: 1108 SMLNQMS 1114
>NP_055797
          Length = 2341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2170 SMVNQM 2175
>XP_005267486
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 1250 SMVNQM 1255
>XP_006720145
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 1252 SMVNQM 1257
>XP_005267485
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 1288 SMVNQM 1293
>XP_005267483
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2059 SMVNQM 2064
>XP_005267482
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2072 SMVNQM 2077
>XP_005267481
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2122 SMVNQM 2127
>XP_005267480
          Length = 2336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2165 SMVNQM 2170
>XP_005267479
          Length = 2344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2173 SMVNQM 2178
>XP_005267478
          Length = 2348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2177 SMVNQM 2182
>XP_005267477
          Length = 2349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SMINQM 7
            SM+NQM
Sbjct: 2178 SMVNQM 2183
>XP_005250292
          Length = 1654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SMINQMN 8
           SM+NQM+
Sbjct: 750 SMLNQMS 756
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.110    0.272 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 287,348
Number of extensions: 458
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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