Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              19     665
NP_001087241                                                           19     665
XP_006714101                                                           19     665
XP_005265799                                                           19     665
XP_005265798                                                           19     665
XP_005265797                                                           19     665
NP_001028198                                                           16    5631
NP_219488                                                              16    5631
NP_006314                                                              16    5631
NP_001036199                                                           16    5631
XP_005259735                                                           16    5631
XP_005259733                                                           16    5631
XP_005259732                                                           16    5631
XP_005262748                                                           16    5631
XP_005262746                                                           16    5631
XP_005262745                                                           16    5631
NP_005273                                                              16    5631
NP_115783                                                              16    5631
NP_061752                                                              16    5631
NP_001139317                                                           16    7355
NP_598334                                                              16    7355
NP_002932                                                              16    7355
NP_001239268                                                           16    7355
NP_001239267                                                           16    7355
NP_001785                                                              16    7355
NP_001276968                                                           16    7355
NP_001276969                                                           16    7355
NP_001122401                                                           16    7355
NP_002010                                                              16    7355
NP_001153392                                                           16    7355
NP_002933                                                              16    7355
NP_001153503                                                           16    7355
NP_001153502                                                           16    7355
NP_071765                                                              16    7355
XP_006713342                                                           16    7355
XP_006713341                                                           16    7355
XP_006713340                                                           16    7355
XP_006713339                                                           16    7355
NP_039225                                                              15    9605
NP_115604                                                              15    9605
NP_851322                                                              15    9605
XP_005275582                                                           15    9605
XP_005275581                                                           15    9605
XP_005275423                                                           15    9605
XP_005275422                                                           15    9605
XP_005275288                                                           15    9605
XP_005275287                                                           15    9605
XP_005275147                                                           15    9605
XP_005275146                                                           15    9605
XP_005274992                                                           15    9605
XP_005274991                                                           15    9605
XP_005272846                                                           15    9605
XP_005272845                                                           15    9605
XP_005274901                                                           15    9605
XP_005274900                                                           15    9605
XP_005249059                                                           15    9605
XP_005249058                                                           15    9605
XP_005265887                                                           15    9605
NP_004937                                                              15    9605
>NP_000213
          Length = 976

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           NSIYVFV D
Sbjct: 105 NSIYVFVRD 113
>NP_001087241
          Length = 972

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           NSIYVFV D
Sbjct: 105 NSIYVFVRD 113
>XP_006714101
          Length = 526

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           NSIYVFV D
Sbjct: 105 NSIYVFVRD 113
>XP_005265799
          Length = 973

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           NSIYVFV D
Sbjct: 105 NSIYVFVRD 113
>XP_005265798
          Length = 976

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           NSIYVFV D
Sbjct: 105 NSIYVFVRD 113
>XP_005265797
          Length = 977

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           NSIYVFV D
Sbjct: 105 NSIYVFVRD 113
>NP_001028198
          Length = 620

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           + I+VF++D
Sbjct: 327 HQIFVFIVD 335
>NP_219488
          Length = 408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           + I+VF++D
Sbjct: 327 HQIFVFIVD 335
>NP_006314
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SIYVFVID 9
           ++Y+FV+D
Sbjct: 678 AVYLFVLD 685
>NP_001036199
          Length = 1233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SIYVFVID 9
           ++Y+FV+D
Sbjct: 643 AVYLFVLD 650
>XP_005259735
          Length = 626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           + I+VF++D
Sbjct: 333 HQIFVFIVD 341
>XP_005259733
          Length = 655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           + I+VF++D
Sbjct: 327 HQIFVFIVD 335
>XP_005259732
          Length = 661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           + I+VF++D
Sbjct: 333 HQIFVFIVD 341
>XP_005262748
          Length = 1263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SIYVFVID 9
           ++Y+FV+D
Sbjct: 673 AVYLFVLD 680
>XP_005262746
          Length = 1298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SIYVFVID 9
           ++Y+FV+D
Sbjct: 708 AVYLFVLD 715
>XP_005262745
          Length = 1299

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SIYVFVID 9
           ++Y+FV+D
Sbjct: 709 AVYLFVLD 716
>NP_005273
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          S+Y+FVI
Sbjct: 22 SLYIFVI 28
>NP_115783
          Length = 878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SIYVFVID 9
           S++VFV+D
Sbjct: 549 SLHVFVLD 556
>NP_061752
          Length = 944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SIYVFVID 9
           S++VFV+D
Sbjct: 549 SLHVFVLD 556
>NP_001139317
          Length = 1551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 591 NAIYLFLV 598
>NP_598334
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 591 NAIYLFLV 598
>NP_002932
          Length = 1651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 627 NAIYLFLV 634
>NP_001239268
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IYVFVID 9
           +Y++VID
Sbjct: 189 LYIYVID 195
>NP_001239267
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IYVFVID 9
           +Y++VID
Sbjct: 226 LYIYVID 232
>NP_001785
          Length = 916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IYVFVID 9
           +Y++VID
Sbjct: 263 LYIYVID 269
>NP_001276968
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 592 NTIYLFMV 599
>NP_001276969
          Length = 1443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 592 NTIYLFMV 599
>NP_001122401
          Length = 1394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 604 NTIYLFMV 611
>NP_002010
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           ++IY+F+ D
Sbjct: 122 SAIYIFISD 130
>NP_001153392
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           ++IY+F+ D
Sbjct: 122 SAIYIFISD 130
>NP_002933
          Length = 1378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 588 NTIYLFMV 595
>NP_001153503
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           ++IY+F+ D
Sbjct: 122 SAIYIFISD 130
>NP_001153502
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NSIYVFVID 9
           ++IY+F+ D
Sbjct: 122 SAIYIFISD 130
>NP_071765
          Length = 1386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 622 NTIYLFLV 629
>XP_006713342
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 608 NTIYLFMV 615
>XP_006713341
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 576 NAIYLFLV 583
>XP_006713340
          Length = 1615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 591 NAIYLFLV 598
>XP_006713339
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NSIYVFVI 8
           N+IY+F++
Sbjct: 592 NAIYLFLV 599
>NP_039225
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>NP_115604
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NSIYVFV 7
          NS+YV V
Sbjct: 38 NSVYVLV 44
>NP_851322
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NSIYVFVI 8
           N +YVF++
Sbjct: 227 NYLYVFIL 234
>XP_005275582
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275581
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275423
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275422
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275288
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275287
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275147
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005275146
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274992
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274991
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005272846
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005272845
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274901
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005274900
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005249059
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005249058
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  SIYVFVI 8
          ++YVF+I
Sbjct: 35 AVYVFII 41
>XP_005265887
          Length = 939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NSIYVFV 7
           +S+YVFV
Sbjct: 221 HSLYVFV 227
>NP_004937
          Length = 1830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NSIYVFV 7
           +S+YVFV
Sbjct: 221 HSLYVFV 227
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.153    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 394,918
Number of extensions: 841
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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