Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     390
XP_005266703                                                           20     390
NP_060649                                                              16    5631
NP_001273443                                                           16    5631
NP_001273444                                                           16    5631
NP_851997                                                              16    5631
NP_054729                                                              16    5631
XP_006719172                                                           16    5631
XP_006719171                                                           16    5631
XP_005253481                                                           16    5631
NP_055794                                                              16    7355
XP_005251238                                                           16    7355
XP_005251237                                                           16    7355
XP_005248527                                                           16    7355
NP_620419                                                              16    7355
NP_001092880                                                           15    9605
NP_001092881                                                           15    9605
NP_055525                                                              15    9605
NP_065816                                                              15    9605
NP_060285                                                              15    9605
NP_055872                                                              15    9605
NP_055475                                                              15    9605
NP_001171656                                                           15    9605
NP_001159742                                                           15    9605
NP_001159741                                                           15    9605
NP_775901                                                              15    9605
XP_005266736                                                           15    9605
XP_006722498                                                           15    9605
XP_006722497                                                           15    9605
XP_006719852                                                           15    9605
XP_005266357                                                           15    9605
XP_006719851                                                           15    9605
XP_006719850                                                           15    9605
XP_006719849                                                           15    9605
XP_006719848                                                           15    9605
XP_005266356                                                           15    9605
XP_006719847                                                           15    9605
XP_006719846                                                           15    9605
XP_006719845                                                           15    9605
XP_006719844                                                           15    9605
XP_006719843                                                           15    9605
XP_006719842                                                           15    9605
XP_005249967                                                           15    9605
XP_005249966                                                           15    9605
XP_006715864                                                           15    9605
XP_005249965                                                           15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605
>NP_443179
          Length = 2170

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SEANDETM 9
           SEANDETM
Sbjct: 744 SEANDETM 751
>XP_005266703
          Length = 1501

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  SEANDETM 9
          SEANDETM
Sbjct: 75 SEANDETM 82
>NP_060649
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           N +AN+ET+
Sbjct: 344 NIDANEETL 352
>NP_001273443
          Length = 1269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           N +AN+ET+
Sbjct: 344 NIDANEETL 352
>NP_001273444
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           N +AN+ET+
Sbjct: 344 NIDANEETL 352
>NP_851997
          Length = 1278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           N +AN+ET+
Sbjct: 352 NIDANEETL 360
>NP_054729
          Length = 1288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEANDET 8
           SEA+DET
Sbjct: 352 SEADDET 358
>XP_006719172
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           N +AN+ET+
Sbjct: 344 NIDANEETL 352
>XP_006719171
          Length = 1270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           N +AN+ET+
Sbjct: 344 NIDANEETL 352
>XP_005253481
          Length = 1277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           N +AN+ET+
Sbjct: 352 NIDANEETL 360
>NP_055794
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NSEANDE 7
          N EAND+
Sbjct: 66 NGEANDD 72
>XP_005251238
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  NSEANDET 8
          N E N+ET
Sbjct: 73 NKEGNEET 80
>XP_005251237
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  NSEANDET 8
          N E N+ET
Sbjct: 73 NKEGNEET 80
>XP_005248527
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NSEANDE 7
          N EAND+
Sbjct: 66 NGEANDD 72
>NP_620419
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  NSEANDET 8
          N E N+ET
Sbjct: 73 NKEGNEET 80
>NP_001092880
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSEANDETM 9
           N EA +ET+
Sbjct: 509 NQEAEEETI 517
>NP_001092881
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSEANDETM 9
           N EA +ET+
Sbjct: 509 NQEAEEETI 517
>NP_055525
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSEANDETM 9
           N EA +ET+
Sbjct: 509 NQEAEEETI 517
>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2809 DADDETM 2815
>NP_060285
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           NS+A+ ET+
Sbjct: 186 NSDADSETV 194
>NP_055872
          Length = 4678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 3999 NSQPNDE 4005
>NP_055475
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NSEANDE 7
           N E NDE
Sbjct: 251 NDEGNDE 257
>NP_001171656
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NSEANDETM 9
           N EA +ET+
Sbjct: 509 NQEAEEETI 517
>NP_001159742
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           NS+A+ ET+
Sbjct: 141 NSDADSETV 149
>NP_001159741
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NSEANDETM 9
           NS+A+ ET+
Sbjct: 186 NSDADSETV 194
>NP_775901
          Length = 2226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    NSEAND 6
            NSE+ND
Sbjct: 1514 NSESND 1519
>XP_005266736
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NSEAND 6
           NSE+ND
Sbjct: 602 NSESND 607
>XP_006722498
          Length = 2059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    NSEAND 6
            NSE+ND
Sbjct: 1515 NSESND 1520
>XP_006722497
          Length = 2227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    NSEAND 6
            NSE+ND
Sbjct: 1515 NSESND 1520
>XP_006719852
          Length = 4752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4073 NSQPNDE 4079
>XP_005266357
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 3921 NSQPNDE 3927
>XP_006719851
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4010 NSQPNDE 4016
>XP_006719850
          Length = 4697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4018 NSQPNDE 4024
>XP_006719849
          Length = 4703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4024 NSQPNDE 4030
>XP_006719848
          Length = 4737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4058 NSQPNDE 4064
>XP_005266356
          Length = 4755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4076 NSQPNDE 4082
>XP_006719847
          Length = 4761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4082 NSQPNDE 4088
>XP_006719846
          Length = 4763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4084 NSQPNDE 4090
>XP_006719845
          Length = 4772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4093 NSQPNDE 4099
>XP_006719844
          Length = 4789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4110 NSQPNDE 4116
>XP_006719843
          Length = 4794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4115 NSQPNDE 4121
>XP_006719842
          Length = 4797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    NSEANDE 7
            NS+ NDE
Sbjct: 4118 NSQPNDE 4124
>XP_005249967
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NSEANDE 7
           N E NDE
Sbjct: 251 NDEGNDE 257
>XP_005249966
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NSEANDE 7
           N E NDE
Sbjct: 251 NDEGNDE 257
>XP_006715864
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NSEANDE 7
           N E NDE
Sbjct: 251 NDEGNDE 257
>XP_005249965
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NSEANDE 7
           N E NDE
Sbjct: 251 NDEGNDE 257
>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2838 DADDETM 2844
>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2849 DADDETM 2855
>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2820 DADDETM 2826
>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2821 DADDETM 2827
>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2838 DADDETM 2844
>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2849 DADDETM 2855
>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2848 DADDETM 2854
>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2848 DADDETM 2854
>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EANDETM 9
            +A+DETM
Sbjct: 2849 DADDETM 2855
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.279   0.0979    0.231 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 538,776
Number of extensions: 1234
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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