Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           19     869
NP_858045                                                              19     869
NP_006525                                                              19     869
NP_001167559                                                           19     869
NP_000236                                                              18    1482
NP_001120972                                                           18    1482
XP_006716052                                                           18    1482
XP_006716051                                                           18    1482
NP_001035545                                                           18    1482
NP_000266                                                              17    4312
XP_005268316                                                           17    4312
NP_056261                                                              16    7355
NP_060082                                                              16    7355
NP_055590                                                              16    7355
NP_001007468                                                           16    7355
NP_001245256                                                           16    7355
NP_001245255                                                           16    7355
NP_001245254                                                           16    7355
XP_005261931                                                           16    7355
XP_006724453                                                           16    7355
XP_005261930                                                           16    7355
XP_006724452                                                           16    7355
XP_005261929                                                           16    7355
XP_005261928                                                           16    7355
XP_005261927                                                           16    7355
XP_006724451                                                           16    7355
XP_005261926                                                           16    7355
XP_005261925                                                           16    7355
XP_006719555                                                           16    7355
XP_005253638                                                           16    7355
XP_006719554                                                           16    7355
XP_006711822                                                           16    7355
XP_006711821                                                           16    7355
NP_065077                                                              15    9605
NP_001180217                                                           15    9605
NP_036440                                                              15    9605
NP_001451                                                              15    9605
NP_115979                                                              15    9605
NP_001005366                                                           15    9605
NP_001243334                                                           15    9605
NP_940931                                                              15    9605
NP_001138525                                                           15    9605
XP_006721944                                                           15    9605
XP_006721943                                                           15    9605
XP_006721942                                                           15    9605
XP_005254018                                                           15    9605
XP_005254013                                                           15    9605
XP_005254012                                                           15    9605
XP_005254011                                                           15    9605
XP_006718544                                                           15    9605
XP_006718543                                                           15    9605
XP_006718542                                                           15    9605
XP_006716813                                                           15    9605
XP_005251482                                                           15    9605
XP_005251483                                                           15    9605
XP_005245096                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NRSLLRNSL 9
            NR LLRNSL
Sbjct: 1026 NRPLLRNSL 1034
>NP_858045
          Length = 1424

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NRSLLRNSL 9
            NR LLRNSL
Sbjct: 1026 NRPLLRNSL 1034
>NP_006525
          Length = 1420

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NRSLLRNSL 9
            NR LLRNSL
Sbjct: 1026 NRPLLRNSL 1034
>NP_001167559
          Length = 1415

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NRSLLRNSL 9
            NR LLRNSL
Sbjct: 1021 NRPLLRNSL 1029
>NP_000236
          Length = 1390

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   NRSLLRNS 8
           NR+LLRNS
Sbjct: 399 NRTLLRNS 406
>NP_001120972
          Length = 1408

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   NRSLLRNS 8
           NR+LLRNS
Sbjct: 399 NRTLLRNS 406
>XP_006716052
          Length = 1409

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   NRSLLRNS 8
           NR+LLRNS
Sbjct: 418 NRTLLRNS 425
>XP_006716051
          Length = 1427

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   NRSLLRNS 8
           NR+LLRNS
Sbjct: 418 NRTLLRNS 425
>NP_001035545
          Length = 832

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NRSLLRNSL 9
           NR+LLRN L
Sbjct: 528 NRALLRNDL 536
>NP_000266
          Length = 838

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           N  LLRNSL
Sbjct: 97  NTPLLRNSL 105
>XP_005268316
          Length = 814

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           N  LLRNSL
Sbjct: 97  NTPLLRNSL 105
>NP_056261
          Length = 2275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RSLLRNSL 9
            RSL RNS+
Sbjct: 998  RSLARNSI 1005
>NP_060082
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSLLRNS 8
           RSLL+NS
Sbjct: 689 RSLLKNS 695
>NP_055590
          Length = 1211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 649 NRQLLRGAL 657
>NP_001007468
          Length = 1242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 680 NRQLLRGAL 688
>NP_001245256
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 598 NRQLLRGAL 606
>NP_001245255
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 598 NRQLLRGAL 606
>NP_001245254
          Length = 1187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 625 NRQLLRGAL 633
>XP_005261931
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 680 NRQLLRGAL 688
>XP_006724453
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 598 NRQLLRGAL 606
>XP_005261930
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 598 NRQLLRGAL 606
>XP_006724452
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 598 NRQLLRGAL 606
>XP_005261929
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 649 NRQLLRGAL 657
>XP_005261928
          Length = 1247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 656 NRQLLRGAL 664
>XP_005261927
          Length = 1247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 656 NRQLLRGAL 664
>XP_006724451
          Length = 1271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 680 NRQLLRGAL 688
>XP_005261926
          Length = 1271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 680 NRQLLRGAL 688
>XP_005261925
          Length = 1271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NRSLLRNSL 9
           NR LLR +L
Sbjct: 680 NRQLLRGAL 688
>XP_006719555
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSLLRNS 8
           RSLL+NS
Sbjct: 451 RSLLKNS 457
>XP_005253638
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSLLRNS 8
           RSLL+NS
Sbjct: 451 RSLLKNS 457
>XP_006719554
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSLLRNS 8
           RSLL+NS
Sbjct: 612 RSLLKNS 618
>XP_006711822
          Length = 2266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RSLLRNSL 9
           RSL RNS+
Sbjct: 989 RSLARNSI 996
>XP_006711821
          Length = 2301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RSLLRNSL 9
            RSL RNS+
Sbjct: 1024 RSLARNSI 1031
>NP_065077
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NRSLLRNSL 9
           + SL+RNS+
Sbjct: 338 HNSLMRNSI 346
>NP_001180217
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NRSLLRNSL 9
           + SL+RNS+
Sbjct: 338 HNSLMRNSI 346
>NP_036440
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NRSLLRN 7
            NRS LRN
Sbjct: 1034 NRSKLRN 1040
>NP_001451
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RSLLRNSL 9
           RS+LRN L
Sbjct: 240 RSMLRNVL 247
>NP_115979
          Length = 1336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NRSLLRN 7
            NRS LRN
Sbjct: 1208 NRSKLRN 1214
>NP_001005366
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NRSLLRN 7
            NRS LRN
Sbjct: 1139 NRSKLRN 1145
>NP_001243334
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NRSLLRN 7
           NRS LRN
Sbjct: 595 NRSKLRN 601
>NP_940931
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RSLLRN 7
           RSLLRN
Sbjct: 425 RSLLRN 430
>NP_001138525
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RSLLRN 7
           RSLLRN
Sbjct: 369 RSLLRN 374
>XP_006721944
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RSLLRN 7
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_006721943
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RSLLRN 7
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_006721942
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RSLLRN 7
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_005254018
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NRSLLRN 7
           NRS LRN
Sbjct: 648 NRSKLRN 654
>XP_005254013
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NRSLLRN 7
            NRS LRN
Sbjct: 1171 NRSKLRN 1177
>XP_005254012
          Length = 1305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NRSLLRN 7
            NRS LRN
Sbjct: 1177 NRSKLRN 1183
>XP_005254011
          Length = 1334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NRSLLRN 7
            NRS LRN
Sbjct: 1208 NRSKLRN 1214
>XP_006718544
          Length = 1056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NRSLLRN 7
           NRS LRN
Sbjct: 928 NRSKLRN 934
>XP_006718543
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NRSLLRN 7
           NRS LRN
Sbjct: 939 NRSKLRN 945
>XP_006718542
          Length = 1145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    NRSLLRN 7
            NRS LRN
Sbjct: 1017 NRSKLRN 1023
>XP_006716813
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NRSLLRNSL 9
           + SL+RNS+
Sbjct: 338 HNSLMRNSI 346
>XP_005251482
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NRSLLRNSL 9
           + SL+RNS+
Sbjct: 338 HNSLMRNSI 346
>XP_005251483
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NRSLLRNSL 9
           + SL+RNS+
Sbjct: 338 HNSLMRNSI 346
>XP_005245096
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RSLLRNSL 9
           RS+LRN L
Sbjct: 240 RSMLRNVL 247
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.130    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 364,860
Number of extensions: 559
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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