Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     299
NP_671714                                                              20     299
XP_006715890                                                           20     299
XP_005250160                                                           20     299
XP_005250159                                                           20     299
NP_001349                                                              18    1935
NP_056513                                                              18    1935
NP_005063                                                              17    3301
NP_001139436                                                           17    3301
NP_001139435                                                           17    3301
NP_001139434                                                           17    3301
NP_005126                                                              17    4312
NP_598408                                                              17    4312
NP_001035959                                                           17    4312
NP_001035962                                                           17    4312
NP_001035960                                                           17    4312
NP_001035961                                                           17    4312
NP_065759                                                              17    4312
NP_001128243                                                           17    4312
NP_006527                                                              17    4312
XP_006720856                                                           17    4312
XP_005273674                                                           17    4312
NP_004322                                                              17    4312
NP_038203                                                              16    5631
NP_056163                                                              16    5631
NP_002152                                                              16    5631
XP_005263969                                                           16    5631
XP_005263968                                                           16    5631
XP_005263967                                                           16    5631
XP_005263966                                                           16    5631
NP_036325                                                              16    7355
NP_002803                                                              16    7355
NP_005227                                                              15    9605
NP_006517                                                              15    9605
NP_002572                                                              15    9605
NP_015628                                                              15    9605
NP_569120                                                              15    9605
NP_569122                                                              15    9605
NP_001387                                                              15    9605
NP_567824                                                              15    9605
NP_006475                                                              15    9605
NP_004705                                                              15    9605
NP_006474                                                              15    9605
NP_653182                                                              15    9605
NP_037382                                                              15    9605
NP_064714                                                              15    9605
XP_005260990                                                           15    9605
XP_005260988                                                           15    9605
XP_006724042                                                           15    9605
XP_006724041                                                           15    9605
XP_006724040                                                           15    9605
XP_006724039                                                           15    9605
XP_005260602                                                           15    9605
XP_006723938                                                           15    9605
XP_005259455                                                           15    9605
XP_006723528                                                           15    9605
XP_006723527                                                           15    9605
XP_005259452                                                           15    9605
XP_006720079                                                           15    9605
XP_006719238                                                           15    9605
XP_005253187                                                           15    9605
XP_006718374                                                           15    9605
XP_005245479                                                           15    9605
XP_006710296                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NQVVEMHTS 9
            +QVVEMHTS
Sbjct: 2613 SQVVEMHTS 2621
>NP_671714
          Length = 3899

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NQVVEMHTS 9
            +QVVEMHTS
Sbjct: 2605 SQVVEMHTS 2613
>XP_006715890
          Length = 3860

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NQVVEMHTS 9
            +QVVEMHTS
Sbjct: 2566 SQVVEMHTS 2574
>XP_005250160
          Length = 3939

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NQVVEMHTS 9
            +QVVEMHTS
Sbjct: 2645 SQVVEMHTS 2653
>XP_005250159
          Length = 3952

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NQVVEMHTS 9
            +QVVEMHTS
Sbjct: 2658 SQVVEMHTS 2666
>NP_001349
          Length = 795

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NQVVEMHTS 9
           NQVV++H S
Sbjct: 716 NQVVQLHPS 724
>NP_056513
          Length = 476

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NQVVEMH 7
           NQVVE+H
Sbjct: 454 NQVVELH 460
>NP_005063
          Length = 1085

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 909 EVVEMHNS 916
>NP_001139436
          Length = 1054

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 878 EVVEMHNS 885
>NP_001139435
          Length = 1079

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 903 EVVEMHNS 910
>NP_001139434
          Length = 1087

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 911 EVVEMHNS 918
>NP_005126
          Length = 1099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 923 EVVEMHDS 930
>NP_598408
          Length = 1150

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 974 EVVEMHDS 981
>NP_001035959
          Length = 1091

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 915 EVVEMHDS 922
>NP_001035962
          Length = 1135

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 959 EVVEMHDS 966
>NP_001035960
          Length = 1091

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 915 EVVEMHDS 922
>NP_001035961
          Length = 1141

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 965 EVVEMHDS 972
>NP_065759
          Length = 1116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 889 EVVEMHES 896
>NP_001128243
          Length = 1139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 912 EVVEMHES 919
>NP_006527
          Length = 943

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QVVEMHT 8
           Q+VE+HT
Sbjct: 341 QIVEIHT 347
>XP_006720856
          Length = 1101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVEMH S
Sbjct: 925 EVVEMHDS 932
>XP_005273674
          Length = 179

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VEMHTS 9
          VEMHTS
Sbjct: 68 VEMHTS 73
>NP_004322
          Length = 219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VEMHTS 9
           VEMHTS
Sbjct: 108 VEMHTS 113
>NP_038203
          Length = 1262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NQVVEMHT 8
            N V+E HT
Sbjct: 1023 NSVIESHT 1030
>NP_056163
          Length = 1883

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVVEMHTS 9
           QVVEM++S
Sbjct: 241 QVVEMYSS 248
>NP_002152
          Length = 1262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NQVVEMHT 8
            N V+E HT
Sbjct: 1023 NSVIESHT 1030
>XP_005263969
          Length = 1844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVVEMHTS 9
           QVVEM++S
Sbjct: 202 QVVEMYSS 209
>XP_005263968
          Length = 1861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVVEMHTS 9
           QVVEM++S
Sbjct: 219 QVVEMYSS 226
>XP_005263967
          Length = 1899

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVVEMHTS 9
           QVVEM++S
Sbjct: 258 QVVEMYSS 265
>XP_005263966
          Length = 1900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVVEMHTS 9
           QVVEM++S
Sbjct: 258 QVVEMYSS 265
>NP_036325
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NQVVEMHTS 9
           ++ +EMH+S
Sbjct: 337 HEAIEMHSS 345
>NP_002803
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NQVVEMHT 8
           N+V E HT
Sbjct: 203 NRVAEFHT 210
>NP_005227
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QVVEMHTS 9
           +VVE+H S
Sbjct: 210 EVVEIHVS 217
>NP_006517
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NQVVEMHTS 9
           N+VV++H +
Sbjct: 200 NEVVQVHAA 208
>NP_002572
          Length = 1627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NQVVEMH 7
           NQV  MH
Sbjct: 650 NQVARMH 656
>NP_015628
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VEMHTS 9
           VE+HTS
Sbjct: 980 VELHTS 985
>NP_569120
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 342 LVEMHT 347
>NP_569122
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 351 LVEMHT 356
>NP_001387
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 351 LVEMHT 356
>NP_567824
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 351 LVEMHT 356
>NP_006475
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 303 LVEMHT 308
>NP_004705
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 303 LVEMHT 308
>NP_006474
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 303 LVEMHT 308
>NP_653182
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VVEMHT 8
          VV+MHT
Sbjct: 22 VVDMHT 27
>NP_037382
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  NQVVEMHTS 9
          N VVE H S
Sbjct: 36 NPVVETHDS 44
>NP_064714
          Length = 1791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NQVVEMH 7
           NQV  MH
Sbjct: 821 NQVARMH 827
>XP_005260990
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 123 LVEMHT 128
>XP_005260988
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 322 LVEMHT 327
>XP_006724042
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 342 LVEMHT 347
>XP_006724041
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 351 LVEMHT 356
>XP_006724040
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 351 LVEMHT 356
>XP_006724039
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 351 LVEMHT 356
>XP_005260602
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NQVVEMHTS 9
           N+VV++H +
Sbjct: 200 NEVVQVHAA 208
>XP_006723938
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NQVVEMHTS 9
           N+VV++H +
Sbjct: 200 NEVVQVHAA 208
>XP_005259455
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 303 LVEMHT 308
>XP_006723528
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 363 LVEMHT 368
>XP_006723527
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 363 LVEMHT 368
>XP_005259452
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVEMHT 8
           +VEMHT
Sbjct: 363 LVEMHT 368
>XP_006720079
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VVEMHT 8
          VV+MHT
Sbjct: 22 VVDMHT 27
>XP_006719238
          Length = 141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  NQVVEMH 7
          N+VV++H
Sbjct: 21 NEVVQLH 27
>XP_005253187
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  NQVVEMHTS 9
          N VVE H S
Sbjct: 36 NPVVETHDS 44
>XP_006718374
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  NQVVEMHTS 9
          N VVE H S
Sbjct: 36 NPVVETHDS 44
>XP_005245479
          Length = 1791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   NQVVEMH 7
           NQV  MH
Sbjct: 821 NQVARMH 827
>XP_006710296
          Length = 141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  NQVVEMH 7
          N+VV++H
Sbjct: 21 NEVVQLH 27
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.111    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 520,786
Number of extensions: 628
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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