Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              18    1482
NP_001005407                                                           17    4312
NP_066921                                                              17    4312
XP_006721032                                                           17    4312
XP_006721031                                                           17    4312
XP_006721030                                                           17    4312
XP_006721029                                                           17    4312
XP_006721028                                                           17    4312
XP_006721027                                                           17    4312
XP_005255709                                                           17    4312
XP_006721026                                                           17    4312
NP_955382                                                              16    5631
NP_001099046                                                           16    5631
NP_001005340                                                           16    5631
NP_002501                                                              16    5631
XP_005249635                                                           16    5631
NP_001753                                                              16    7355
NP_006575                                                              16    7355
NP_001180458                                                           16    7355
NP_001693                                                              16    7355
NP_001244299                                                           16    7355
XP_006726895                                                           16    7355
XP_006724469                                                           16    7355
XP_006721705                                                           16    7355
XP_006721704                                                           16    7355
XP_005255219                                                           16    7355
XP_005251072                                                           16    7355
NP_620687                                                              15    9605
NP_001243463                                                           15    9605
NP_001186434                                                           15    9605
NP_055592                                                              15    9605
NP_001136095                                                           15    9605
NP_001136094                                                           15    9605
NP_001135916                                                           15    9605
NP_001135915                                                           15    9605
NP_787068                                                              15    9605
NP_065768                                                              15    9605
NP_115873                                                              15    9605
NP_079359                                                              15    9605
NP_001161458                                                           15    9605
NP_998891                                                              15    9605
NP_001138584                                                           15    9605
NP_899067                                                              15    9605
NP_001268436                                                           15    9605
NP_542403                                                              15    9605
NP_899069                                                              15    9605
NP_001186435                                                           15    9605
XP_006724654                                                           15    9605
XP_006724653                                                           15    9605
XP_005258576                                                           15    9605
XP_005256686                                                           15    9605
XP_006721582                                                           15    9605
XP_006721581                                                           15    9605
XP_006721580                                                           15    9605
XP_005256685                                                           15    9605
XP_005256684                                                           15    9605
XP_006712418                                                           15    9605
XP_006712417                                                           15    9605
XP_006712415                                                           15    9605
XP_006712414                                                           15    9605
XP_006712413                                                           15    9605
XP_006712412                                                           15    9605
XP_005273417                                                           15    9605
NP_001161457                                                           15    9605
NP_001161459                                                           15    9605
>NP_055365
          Length = 1032

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NQRPTASLR 9
           NQR TASLR
Sbjct: 287 NQRLTASLR 295
>NP_001005407
          Length = 2347

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>NP_066921
          Length = 2353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_006721032
          Length = 1566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_006721031
          Length = 1612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_006721030
          Length = 1618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_006721029
          Length = 1820

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_006721028
          Length = 2336

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_006721027
          Length = 2342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_005255709
          Length = 2347

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>XP_006721026
          Length = 2358

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NQRPTASLR 9
            +Q+P ASLR
Sbjct: 1117 DQKPPASLR 1125
>NP_955382
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QRPTASLR 9
           QRP +SLR
Sbjct: 378 QRPRSSLR 385
>NP_001099046
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NQRPTASL 8
          N+ PTASL
Sbjct: 9  NRAPTASL 16
>NP_001005340
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NQRPTASLR 9
          N+RP+A +R
Sbjct: 31 NERPSAYMR 39
>NP_002501
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NQRPTASLR 9
          N+RP+A +R
Sbjct: 31 NERPSAYMR 39
>XP_005249635
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NQRPTASLR 9
          N+RP+A +R
Sbjct: 31 NERPSAYMR 39
>NP_001753
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  QRPTASL 8
          Q PTASL
Sbjct: 70 QHPTASL 76
>NP_006575
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  QRPTASL 8
          Q PTASL
Sbjct: 70 QHPTASL 76
>NP_001180458
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  QRPTASL 8
          Q PTASL
Sbjct: 70 QHPTASL 76
>NP_001693
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NQRPTASLR 9
            N+RP  SLR
Sbjct: 1527 NKRPWESLR 1535
>NP_001244299
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QRPTASLR 9
           QRP  SLR
Sbjct: 109 QRPARSLR 116
>XP_006726895
          Length = 2288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PTASLR 9
           PTASLR
Sbjct: 511 PTASLR 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PTASLR 9
           PTASLR
Sbjct: 672 PTASLR 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PTASLR 9
           PTASLR
Sbjct: 966 PTASLR 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    PTASLR 9
            PTASLR
Sbjct: 1078 PTASLR 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    PTASLR 9
            PTASLR
Sbjct: 1557 PTASLR 1562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    PTASLR 9
            PTASLR
Sbjct: 1710 PTASLR 1715
>XP_006724469
          Length = 2373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PTASLR 9
           PTASLR
Sbjct: 544 PTASLR 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PTASLR 9
           PTASLR
Sbjct: 971 PTASLR 976

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    PTASLR 9
            PTASLR
Sbjct: 1242 PTASLR 1247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    PTASLR 9
            PTASLR
Sbjct: 1848 PTASLR 1853
>XP_006721705
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  QRPTASL 8
          Q PTASL
Sbjct: 4  QHPTASL 10
>XP_006721704
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  QRPTASL 8
          Q PTASL
Sbjct: 70 QHPTASL 76
>XP_005255219
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QRPTASLR 9
          QRP  SLR
Sbjct: 81 QRPARSLR 88
>XP_005251072
          Length = 1586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    NQRPTASLR 9
            N+RP  SLR
Sbjct: 1529 NKRPWESLR 1537
>NP_620687
          Length = 1224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NQRPTASL 8
            +Q+P+ASL
Sbjct: 1166 HQKPSASL 1173
>NP_001243463
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QRPTASLR 9
          QRP  SLR
Sbjct: 24 QRPGGSLR 31
>NP_001186434
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 481 NQRPT 485
>NP_055592
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQR TAS
Sbjct: 716 NQRTTAS 722
>NP_001136095
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QRPTASLR 9
          QRP  SLR
Sbjct: 78 QRPHCSLR 85
>NP_001136094
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QRPTASLR 9
          QRP  SLR
Sbjct: 78 QRPHCSLR 85
>NP_001135916
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NQRPTASL 8
           +QRPT +L
Sbjct: 332 HQRPTVAL 339
>NP_001135915
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NQRPTASL 8
           +QRPT +L
Sbjct: 332 HQRPTVAL 339
>NP_787068
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 572 NQRPT 576
>NP_065768
          Length = 1493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NQRPTAS 7
           NQ+P+AS
Sbjct: 524 NQQPSAS 530
>NP_115873
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QRPTASLR 9
          QRP  SLR
Sbjct: 78 QRPHCSLR 85
>NP_079359
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NQRPTASL 8
           +QRPT +L
Sbjct: 332 HQRPTVAL 339
>NP_001161458
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>NP_998891
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>NP_001138584
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   QRPTASL 8
           Q PTASL
Sbjct: 501 QMPTASL 507
>NP_899067
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 443 NQRPT 447
>NP_001268436
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 443 NQRPT 447
>NP_542403
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 484 NQRPT 488
>NP_899069
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 373 NQRPT 377
>NP_001186435
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 443 NQRPT 447
>XP_006724654
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NQRPTAS 7
           NQ+P+AS
Sbjct: 366 NQQPSAS 372
>XP_006724653
          Length = 1377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NQRPTAS 7
           NQ+P+AS
Sbjct: 408 NQQPSAS 414
>XP_005258576
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NQRPT 5
           NQRPT
Sbjct: 531 NQRPT 535
>XP_005256686
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>XP_006721582
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>XP_006721581
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>XP_006721580
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>XP_005256685
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>XP_005256684
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>XP_006712418
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQ+PT S
Sbjct: 520 NQKPTES 526
>XP_006712417
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQ+PT S
Sbjct: 644 NQKPTES 650
>XP_006712415
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQ+PT S
Sbjct: 803 NQKPTES 809
>XP_006712414
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQ+PT S
Sbjct: 805 NQKPTES 811
>XP_006712413
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQ+PT S
Sbjct: 805 NQKPTES 811
>XP_006712412
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQ+PT S
Sbjct: 805 NQKPTES 811
>XP_005273417
          Length = 1487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NQRPTAS 7
           NQR TAS
Sbjct: 716 NQRTTAS 722
>NP_001161457
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
>NP_001161459
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NQRPT 5
          NQRPT
Sbjct: 49 NQRPT 53
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.118    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 734,478
Number of extensions: 816
Number of successful extensions: 73
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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