Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              21     229
XP_005251512                                                           21     229
NP_057409                                                              18    1935
NP_598009                                                              18    1935
NP_001265663                                                           18    1935
NP_057408                                                              18    1935
NP_001243687                                                           17    2528
XP_006722543                                                           17    2528
NP_689683                                                              17    2528
NP_068598                                                              17    3301
NP_620709                                                              17    4312
NP_620708                                                              17    4312
NP_001185761                                                           16    5631
NP_001185763                                                           16    5631
NP_055459                                                              16    5631
NP_055491                                                              16    5631
NP_001018494                                                           16    5631
NP_001002811                                                           16    5631
NP_002214                                                              16    5631
NP_001002812                                                           16    5631
XP_006726410                                                           16    5631
XP_006719127                                                           16    5631
XP_006711719                                                           16    5631
XP_006711717                                                           16    5631
XP_006711716                                                           16    5631
XP_006711715                                                           16    5631
XP_006711714                                                           16    5631
XP_006711713                                                           16    5631
XP_006711712                                                           16    5631
XP_006711711                                                           16    5631
XP_006711710                                                           16    5631
XP_006711709                                                           16    5631
XP_005277503                                                           16    5631
XP_005273038                                                           16    5631
XP_006711708                                                           16    5631
XP_005277500                                                           16    5631
XP_006711707                                                           16    5631
XP_005277499                                                           16    5631
XP_006711706                                                           16    5631
XP_006711705                                                           16    5631
XP_006711164                                                           16    5631
NP_001001976                                                           16    7355
NP_001275663                                                           16    7355
NP_001001483                                                           16    7355
NP_056132                                                              16    7355
NP_001269720                                                           16    7355
NP_001269681                                                           16    7355
NP_001269719                                                           16    7355
NP_061901                                                              16    7355
NP_003096                                                              16    7355
XP_005253053                                                           16    7355
XP_005269518                                                           16    7355
XP_005269516                                                           16    7355
XP_005269515                                                           16    7355
XP_005269513                                                           16    7355
XP_005262667                                                           16    7355
XP_005262666                                                           16    7355
XP_006712038                                                           16    7355
XP_006712037                                                           16    7355
XP_006712036                                                           16    7355
XP_006712035                                                           16    7355
XP_005262664                                                           16    7355
NP_000206                                                              15    9605
NP_008859                                                              15    9605
NP_001186982                                                           15    9605
NP_001186983                                                           15    9605
XP_006722808                                                           15    9605
XP_005259953                                                           15    9605
XP_006719632                                                           15    9605
XP_006719631                                                           15    9605
>NP_004963
          Length = 1132

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           NQMV HKIR
Sbjct: 533 NQMVFHKIR 541
>XP_005251512
          Length = 1132

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           NQMV HKIR
Sbjct: 533 NQMVFHKIR 541
>NP_057409
          Length = 621

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NQMVLHKI 8
           NQ++LHKI
Sbjct: 405 NQVLLHKI 412
>NP_598009
          Length = 653

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NQMVLHKI 8
           NQ++LHKI
Sbjct: 437 NQVLLHKI 444
>NP_001265663
          Length = 611

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NQMVLHKI 8
           NQ++LHKI
Sbjct: 395 NQVLLHKI 402
>NP_057408
          Length = 548

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NQMVLHKI 8
           NQ++LHKI
Sbjct: 332 NQVLLHKI 339
>NP_001243687
          Length = 154

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  QMVLHKIR 9
          QMV+H+IR
Sbjct: 12 QMVVHEIR 19
>XP_006722543
          Length = 369

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           QMV+H+IR
Sbjct: 227 QMVVHEIR 234
>NP_689683
          Length = 346

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           QMV+H+IR
Sbjct: 204 QMVVHEIR 211
>NP_068598
          Length = 764

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           +++LHK+R
Sbjct: 145 ELILHKVR 152
>NP_620709
          Length = 424

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMVLHKI 8
           +MVLHK+
Sbjct: 217 EMVLHKV 223
>NP_620708
          Length = 382

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMVLHKI 8
           +MVLHK+
Sbjct: 217 EMVLHKV 223
>NP_001185761
          Length = 2240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 536 NEMLLEKLR 544
>NP_001185763
          Length = 2362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 470 NEMLLEKLR 478
>NP_055459
          Length = 2346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 470 NEMLLEKLR 478
>NP_055491
          Length = 1186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    QMVLHKIR 9
            ++V+HKIR
Sbjct: 1138 KIVMHKIR 1145
>NP_001018494
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    QMVLHKIR 9
            ++V+HKIR
Sbjct: 1140 KIVMHKIR 1147
>NP_001002811
          Length = 1132

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>NP_002214
          Length = 2701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NQMVLHK 7
            NQ++LHK
Sbjct: 1252 NQVLLHK 1258
>NP_001002812
          Length = 969

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 470 NEMLLEKLR 478
>XP_006726410
          Length = 2087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 545 NEMLLEKLR 553
>XP_006719127
          Length = 1865

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NQMVLHK 7
            NQ++LHK
Sbjct: 1252 NQVLLHK 1258
>XP_006711719
          Length = 2302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 536 NEMLLEKLR 544
>XP_006711717
          Length = 2385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 536 NEMLLEKLR 544
>XP_006711716
          Length = 2411

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 536 NEMLLEKLR 544
>XP_006711715
          Length = 2428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 470 NEMLLEKLR 478
>XP_006711714
          Length = 2429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 470 NEMLLEKLR 478
>XP_006711713
          Length = 2432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 473 NEMLLEKLR 481
>XP_006711712
          Length = 2473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_006711711
          Length = 2482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_006711710
          Length = 2494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 536 NEMLLEKLR 544
>XP_006711709
          Length = 2495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 536 NEMLLEKLR 544
>XP_005277503
          Length = 2498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_005273038
          Length = 2509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_006711708
          Length = 2512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_005277500
          Length = 2525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_006711707
          Length = 2553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_005277499
          Length = 2561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_006711706
          Length = 2591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_006711705
          Length = 2592

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 633 NEMLLEKLR 641
>XP_006711164
          Length = 2087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           N+M+L K+R
Sbjct: 545 NEMLLEKLR 553
>NP_001001976
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMVLHK 7
           QMV+HK
Sbjct: 299 QMVIHK 304
>NP_001275663
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMVLHK 7
           QMV+HK
Sbjct: 184 QMVIHK 189
>NP_001001483
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           NQ+++H ++
Sbjct: 132 NQLIIHMLK 140
>NP_056132
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    QMVLHKIR 9
            ++++HKIR
Sbjct: 1016 KIIMHKIR 1023
>NP_001269720
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           ++++HKIR
Sbjct: 881 KIIMHKIR 888
>NP_001269681
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           ++++HKIR
Sbjct: 960 KIIMHKIR 967
>NP_001269719
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           ++++HKIR
Sbjct: 937 KIIMHKIR 944
>NP_061901
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           NQ+++H ++
Sbjct: 262 NQLIIHMLK 270
>NP_003096
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NQMVLH 6
           NQMV+H
Sbjct: 103 NQMVVH 108
>XP_005253053
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   NQMVLHKIR 9
           NQ+++H ++
Sbjct: 132 NQLIIHMLK 140
>XP_005269518
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMVLHK 7
           QMV+HK
Sbjct: 316 QMVIHK 321
>XP_005269516
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMVLHK 7
           QMV+HK
Sbjct: 292 QMVIHK 297
>XP_005269515
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMVLHK 7
           QMV+HK
Sbjct: 299 QMVIHK 304
>XP_005269513
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMVLHK 7
           QMV+HK
Sbjct: 316 QMVIHK 321
>XP_005262667
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           ++++HKIR
Sbjct: 937 KIIMHKIR 944
>XP_005262666
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           ++++HKIR
Sbjct: 939 KIIMHKIR 946
>XP_006712038
          Length = 1010

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QMVLHKIR 9
           ++++HKIR
Sbjct: 962 KIIMHKIR 969
>XP_006712037
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    QMVLHKIR 9
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>XP_006712036
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    QMVLHKIR 9
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>XP_006712035
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    QMVLHKIR 9
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>XP_005262664
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    QMVLHKIR 9
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>NP_000206
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NQMVLHKI 8
           +QM  HKI
Sbjct: 509 SQMTFHKI 516
>NP_008859
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMVLHKI 8
           Q+VLH+I
Sbjct: 551 QLVLHQI 557
>NP_001186982
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMVLHKI 8
           Q+VLH+I
Sbjct: 465 QLVLHQI 471
>NP_001186983
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMVLHKI 8
           Q+VLH+I
Sbjct: 551 QLVLHQI 557
>XP_006722808
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NQMVLHKI 8
           +QM  HKI
Sbjct: 509 SQMTFHKI 516
>XP_005259953
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NQMVLHKI 8
           +QM  HKI
Sbjct: 552 SQMTFHKI 559
>XP_006719632
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMVLHKI 8
           Q+VLH+I
Sbjct: 551 QLVLHQI 557
>XP_006719631
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMVLHKI 8
           Q+VLH+I
Sbjct: 554 QLVLHQI 560
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.139    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 482,442
Number of extensions: 728
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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