Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           21     229
NP_055903                                                              21     229
NP_065783                                                              17    3301
NP_059989                                                              17    3301
XP_006715590                                                           17    3301
XP_005267126                                                           17    3301
XP_006715589                                                           17    3301
XP_006715588                                                           17    3301
XP_006715587                                                           17    3301
XP_006715586                                                           17    3301
XP_005257123                                                           17    4312
NP_065188                                                              16    5631
NP_001027566                                                           16    5631
NP_001027567                                                           16    5631
NP_940971                                                              16    5631
NP_061867                                                              16    5631
NP_037411                                                              16    5631
NP_001120864                                                           16    5631
NP_004684                                                              16    5631
NP_932157                                                              16    5631
NP_201574                                                              16    5631
NP_001119530                                                           16    5631
NP_001119529                                                           16    5631
XP_006723539                                                           16    5631
XP_005274286                                                           16    5631
XP_005274285                                                           16    5631
XP_005274284                                                           16    5631
XP_005274283                                                           16    5631
XP_005274282                                                           16    5631
XP_005274281                                                           16    5631
XP_005274280                                                           16    5631
XP_005274279                                                           16    5631
XP_005267118                                                           16    5631
XP_006715581                                                           16    5631
XP_006715580                                                           16    5631
XP_006715579                                                           16    5631
XP_006710761                                                           16    5631
XP_006710465                                                           16    5631
XP_006710464                                                           16    5631
NP_001177278                                                           16    5631
NP_001177277                                                           16    5631
NP_940867                                                              16    7355
NP_009087                                                              16    7355
NP_009088                                                              16    7355
NP_004789                                                              16    7355
NP_009145                                                              16    7355
NP_055501                                                              16    7355
XP_006724697                                                           16    7355
XP_006724696                                                           16    7355
XP_006724695                                                           16    7355
XP_006724694                                                           16    7355
XP_005259501                                                           16    7355
XP_006712667                                                           16    7355
XP_006712666                                                           16    7355
XP_006712665                                                           16    7355
XP_006712664                                                           16    7355
NP_036336                                                              16    7355
NP_001254652                                                           15    9605
NP_001138830                                                           15    9605
NP_001138829                                                           15    9605
NP_056292                                                              15    9605
NP_001191125                                                           15    9605
XP_005276342                                                           15    9605
XP_005259249                                                           15    9605
XP_005259248                                                           15    9605
XP_006720530                                                           15    9605
XP_006720529                                                           15    9605
XP_006720528                                                           15    9605
NP_060703                                                              15    9605
>NP_001155973
          Length = 1833

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           NNNRS GGS
Sbjct: 475 NNNRSTGGS 483
>NP_055903
          Length = 1723

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           NNNRS GGS
Sbjct: 475 NNNRSTGGS 483
>NP_065783
          Length = 2249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 135 SNNNSLGGA 143
>NP_059989
          Length = 2236

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 135 SNNNSLGGA 143
>XP_006715590
          Length = 2277

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 162 SNNNSLGGA 170
>XP_005267126
          Length = 2316

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 162 SNNNSLGGA 170
>XP_006715589
          Length = 2320

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 162 SNNNSLGGA 170
>XP_006715588
          Length = 2330

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 162 SNNNSLGGA 170
>XP_006715587
          Length = 2359

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 162 SNNNSLGGA 170
>XP_006715586
          Length = 2373

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NNNRSMGGS 9
           +NN S+GG+
Sbjct: 162 SNNNSLGGA 170
>XP_005257123
          Length = 803

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NNRSMGGS 9
           NN  MGGS
Sbjct: 207 NNARMGGS 214
>NP_065188
          Length = 1221

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 809 NKNKSFGG 816
>NP_001027566
          Length = 1193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 781 NKNKSFGG 788
>NP_001027567
          Length = 1222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 781 NKNKSFGG 788
>NP_940971
          Length = 1250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 809 NKNKSFGG 816
>NP_061867
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NNRSMGGS 9
           +NR++GGS
Sbjct: 519 DNRTVGGS 526
>NP_037411
          Length = 1111

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 93  NNNNGMGAA 101
>NP_001120864
          Length = 1151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>NP_004684
          Length = 551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NNRSMGGS 9
           +NR +GGS
Sbjct: 525 SNRGLGGS 532
>NP_932157
          Length = 858

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  NNRSMGGS 9
          NN S GGS
Sbjct: 30 NNSSSGGS 37
>NP_201574
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NN  S GGS
Sbjct: 264 NNGSSSGGS 272
>NP_001119530
          Length = 386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NN  S GGS
Sbjct: 264 NNGSSSGGS 272
>NP_001119529
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NN  S GGS
Sbjct: 264 NNGSSSGGS 272
>XP_006723539
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NN  S GGS
Sbjct: 264 NNGSSSGGS 272
>XP_005274286
          Length = 1038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005274285
          Length = 1101

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005274284
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005274283
          Length = 1124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005274282
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005274281
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005274280
          Length = 1147

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005274279
          Length = 1152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NNN  MG +
Sbjct: 102 NNNNGMGAA 110
>XP_005267118
          Length = 1222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 810 NKNKSFGG 817
>XP_006715581
          Length = 1223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 782 NKNKSFGG 789
>XP_006715580
          Length = 1249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 808 NKNKSFGG 815
>XP_006715579
          Length = 1251

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 810 NKNKSFGG 817
>XP_006710761
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NNRSMGGS 9
           +NR++GGS
Sbjct: 519 DNRTVGGS 526
>XP_006710465
          Length = 524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  NNRSMGGS 9
          NN S GGS
Sbjct: 30 NNSSSGGS 37
>XP_006710464
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  NNRSMGGS 9
          NN S GGS
Sbjct: 30 NNSSSGGS 37
>NP_001177278
          Length = 369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NN  S GGS
Sbjct: 264 NNGSSSGGS 272
>NP_001177277
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NNNRSMGGS 9
           NN  S GGS
Sbjct: 264 NNGSSSGGS 272
>NP_940867
          Length = 1582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    NRSMGGS 9
            NRS GGS
Sbjct: 1025 NRSHGGS 1031
>NP_009087
          Length = 799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NNNRSMG 7
           NNN S+G
Sbjct: 647 NNNNSVG 653
>NP_009088
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NNNRSMG 7
           NNN S+G
Sbjct: 651 NNNNSVG 657
>NP_004789
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NNNRSMGGS 9
           N NRS+G +
Sbjct: 198 NQNRSVGAT 206
>NP_009145
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N NR+ GG
Sbjct: 505 NKNRTKGG 512
>NP_055501
          Length = 1070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 524 NGNKSSGG 531
>XP_006724697
          Length = 1526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    NRSMGGS 9
            NRS GGS
Sbjct: 1025 NRSHGGS 1031
>XP_006724696
          Length = 1534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    NRSMGGS 9
            NRS GGS
Sbjct: 1025 NRSHGGS 1031
>XP_006724695
          Length = 1574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    NRSMGGS 9
            NRS GGS
Sbjct: 1025 NRSHGGS 1031
>XP_006724694
          Length = 1582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    NRSMGGS 9
            NRS GGS
Sbjct: 1025 NRSHGGS 1031
>XP_005259501
          Length = 1070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           N N+S GG
Sbjct: 524 NGNKSSGG 531
>XP_006712667
          Length = 1733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NNNRSMGGS 9
           NNN + GG+
Sbjct: 409 NNNLNRGGT 417
>XP_006712666
          Length = 1816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NNNRSMGGS 9
           NNN + GG+
Sbjct: 409 NNNLNRGGT 417
>XP_006712665
          Length = 1824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NNNRSMGGS 9
           NNN + GG+
Sbjct: 409 NNNLNRGGT 417
>XP_006712664
          Length = 1825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NNNRSMGGS 9
           NNN + GG+
Sbjct: 409 NNNLNRGGT 417
>NP_036336
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NNNRSMGG 8
           +NNR M G
Sbjct: 323 HNNRKMSG 330
>NP_001254652
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   NRSMGG 8
           NR MGG
Sbjct: 97  NRKMGG 102
>NP_001138830
          Length = 1273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NNNRSMGG 8
            NNN + GG
Sbjct: 1028 NNNGATGG 1035
>NP_001138829
          Length = 1273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NNNRSMGG 8
            NNN + GG
Sbjct: 1028 NNNGATGG 1035
>NP_056292
          Length = 1273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NNNRSMGG 8
            NNN + GG
Sbjct: 1028 NNNGATGG 1035
>NP_001191125
          Length = 78

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  NNNRSMGGS 9
          ++NR MG S
Sbjct: 60 SSNRKMGAS 68
>XP_005276342
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NNNRSMGG 8
           N N+++GG
Sbjct: 293 NKNKNVGG 300
>XP_005259249
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   NRSMGG 8
           NR MGG
Sbjct: 97  NRKMGG 102
>XP_005259248
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   NRSMGG 8
           NR MGG
Sbjct: 105 NRKMGG 110
>XP_006720530
          Length = 1273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NNNRSMGG 8
            NNN + GG
Sbjct: 1028 NNNGATGG 1035
>XP_006720529
          Length = 1273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NNNRSMGG 8
            NNN + GG
Sbjct: 1028 NNNGATGG 1035
>XP_006720528
          Length = 1273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    NNNRSMGG 8
            NNN + GG
Sbjct: 1028 NNNGATGG 1035
>NP_060703
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NRSMGGS 9
           +RSMGG+
Sbjct: 175 DRSMGGT 181
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.116    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 731,062
Number of extensions: 1146
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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