Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_660153                                                              18    1135
XP_006717676                                                           18    1135
XP_006717675                                                           18    1135
XP_006717674                                                           18    1135
XP_006717673                                                           18    1135
XP_006717672                                                           18    1135
XP_005269546                                                           18    1135
XP_005269545                                                           18    1135
XP_006717671                                                           18    1135
XP_006717670                                                           18    1135
XP_006717669                                                           18    1135
XP_006717668                                                           18    1135
XP_006717667                                                           18    1135
NP_006720                                                              17    4312
NP_009293                                                              17    4312
NP_612200                                                              16    5631
NP_056083                                                              16    5631
XP_005247302                                                           16    5631
NP_001239542                                                           16    7355
NP_001239541                                                           16    7355
NP_001014972                                                           16    7355
NP_055312                                                              16    7355
XP_006712053                                                           16    7355
XP_005264320                                                           16    7355
XP_006712052                                                           16    7355
XP_005264319                                                           16    7355
XP_005264318                                                           16    7355
NP_001248319                                                           15    9605
NP_005822                                                              15    9605
NP_001248320                                                           15    9605
NP_001186797                                                           15    9605
NP_001092314                                                           15    9605
NP_001248324                                                           15    9605
XP_006722105                                                           15    9605
XP_005258083                                                           15    9605
XP_005258084                                                           15    9605
NP_003161                                                              15    9605
NP_006532                                                              15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NNDVRAELA 9
            +NDVRAELA
Sbjct: 3589 SNDVRAELA 3597
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NNDVRAELA 9
            +NDVRAELA
Sbjct: 3589 SNDVRAELA 3597
>NP_660153
          Length = 1121

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 751 NNDIRMEMA 759
>XP_006717676
          Length = 793

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 751 NNDIRMEMA 759
>XP_006717675
          Length = 877

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 751 NNDIRMEMA 759
>XP_006717674
          Length = 929

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 559 NNDIRMEMA 567
>XP_006717673
          Length = 929

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 559 NNDIRMEMA 567
>XP_006717672
          Length = 929

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 559 NNDIRMEMA 567
>XP_005269546
          Length = 929

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 559 NNDIRMEMA 567
>XP_005269545
          Length = 1051

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 681 NNDIRMEMA 689
>XP_006717671
          Length = 1091

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 751 NNDIRMEMA 759
>XP_006717670
          Length = 1120

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 750 NNDIRMEMA 758
>XP_006717669
          Length = 1120

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 750 NNDIRMEMA 758
>XP_006717668
          Length = 1121

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 751 NNDIRMEMA 759
>XP_006717667
          Length = 1121

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NNDVRAELA 9
           NND+R E+A
Sbjct: 751 NNDIRMEMA 759
>NP_006720
          Length = 1101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NDVRAEL 8
           ND+RAE+
Sbjct: 396 NDIRAEM 402
>NP_009293
          Length = 1096

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NDVRAEL 8
           ND+RAE+
Sbjct: 396 NDIRAEM 402
>NP_612200
          Length = 339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NNDVRAEL 8
          +NDVRA L
Sbjct: 19 SNDVRASL 26
>NP_056083
          Length = 2243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NNDVRAEL 8
            NN  RAEL
Sbjct: 1645 NNSTRAEL 1652
>XP_005247302
          Length = 2248

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NNDVRAEL 8
            NN  RAEL
Sbjct: 1650 NNSTRAEL 1657
>NP_001239542
          Length = 1957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1787 DNDLKVELA 1795
>NP_001239541
          Length = 1978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1787 DNDLKVELA 1795
>NP_001014972
          Length = 1978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1787 DNDLKVELA 1795
>NP_055312
          Length = 1978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1787 DNDLKVELA 1795
>XP_006712053
          Length = 1467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1276 DNDLKVELA 1284
>XP_005264320
          Length = 1467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1276 DNDLKVELA 1284
>XP_006712052
          Length = 1467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1276 DNDLKVELA 1284
>XP_005264319
          Length = 2049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1893 DNDLKVELA 1901
>XP_005264318
          Length = 2084

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NNDVRAELA 9
            +ND++ ELA
Sbjct: 1893 DNDLKVELA 1901
>NP_001248319
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NNDVRAEL 8
           N+D++AEL
Sbjct: 194 NSDMQAEL 201
>NP_005822
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NNDVRAEL 8
           N+D++AEL
Sbjct: 170 NSDMQAEL 177
>NP_001248320
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NNDVRAEL 8
           N+D++AEL
Sbjct: 191 NSDMQAEL 198
>NP_001186797
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NDVRAELA 9
          N+V AELA
Sbjct: 50 NEVMAELA 57
>NP_001092314
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DVRAEL 8
           DVRAEL
Sbjct: 232 DVRAEL 237
>NP_001248324
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NNDVRAEL 8
           N+D++AEL
Sbjct: 98  NSDMQAEL 105
>XP_006722105
          Length = 1603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DVRAELA 9
            D+RAEL+
Sbjct: 1002 DIRAELS 1008
>XP_005258083
          Length = 1726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DVRAELA 9
            D+RAEL+
Sbjct: 1125 DIRAELS 1131
>XP_005258084
          Length = 1726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DVRAELA 9
            D+RAEL+
Sbjct: 1125 DIRAELS 1131
>NP_003161
          Length = 1726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DVRAELA 9
            D+RAEL+
Sbjct: 1125 DIRAELS 1131
>NP_006532
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NDVRAELA 9
          N+V AELA
Sbjct: 50 NEVMAELA 57
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.122    0.309 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 390,438
Number of extensions: 516
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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