Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718908                                                           20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_940820                                                              17    2528
NP_001028776                                                           17    2528
NP_001028777                                                           17    2528
NP_055266                                                              17    2528
XP_006715751                                                           17    2528
XP_005249757                                                           17    2528
XP_006715750                                                           17    2528
NP_005711                                                              17    3301
XP_006715889                                                           17    3301
XP_006715888                                                           17    3301
NP_001265611                                                           17    4312
NP_775299                                                              17    4312
NP_003235                                                              17    4312
NP_775303                                                              17    4312
NP_775302                                                              17    4312
NP_775301                                                              17    4312
NP_001265615                                                           17    4312
NP_777480                                                              17    4312
NP_733796                                                              17    4312
NP_001265613                                                           17    4312
NP_775300                                                              17    4312
NP_004923                                                              17    4312
NP_057363                                                              17    4312
XP_005258192                                                           17    4312
NP_060682                                                              16    5631
NP_001008493                                                           16    5631
XP_005273239                                                           16    5631
XP_005273246                                                           16    5631
XP_005273245                                                           16    5631
XP_006711860                                                           16    5631
XP_006711859                                                           16    5631
XP_005273244                                                           16    5631
XP_006711858                                                           16    5631
XP_006711856                                                           16    5631
XP_006711855                                                           16    5631
XP_006711854                                                           16    5631
XP_006711853                                                           16    5631
XP_006711852                                                           16    5631
XP_006711851                                                           16    5631
XP_006711850                                                           16    5631
XP_006711849                                                           16    5631
NP_065988                                                              16    7355
NP_005235                                                              16    7355
NP_742108                                                              16    7355
NP_001185780                                                           16    7355
NP_001185779                                                           16    7355
NP_001185781                                                           16    7355
NP_055762                                                              16    7355
NP_057302                                                              16    7355
XP_005267986                                                           16    7355
XP_006714715                                                           16    7355
XP_006714714                                                           16    7355
XP_006714713                                                           16    7355
XP_005248591                                                           16    7355
XP_006710522                                                           16    7355
XP_006710521                                                           16    7355
XP_005270689                                                           16    7355
NP_277045                                                              15    9605
NP_001004470                                                           15    9605
NP_060639                                                              15    9605
XP_006719162                                                           15    9605
XP_005253462                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NMPKQSSQL 9
            N+PKQSSQL
Sbjct: 2586 NVPKQSSQL 2594
>XP_006718908
          Length = 1708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NMPKQSSQL 9
            N+PKQSSQL
Sbjct: 1238 NVPKQSSQL 1246
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NMPKQSSQL 9
            N+PKQSSQL
Sbjct: 2238 NVPKQSSQL 2246
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NMPKQSSQL 9
            N+PKQSSQL
Sbjct: 2580 NVPKQSSQL 2588
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NMPKQSSQL 9
            N+PKQSSQL
Sbjct: 2586 NVPKQSSQL 2594
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NMPKQSSQL 9
            N+PKQSSQL
Sbjct: 2586 NVPKQSSQL 2594
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NMPKQSSQL 9
            N+PKQSSQL
Sbjct: 2586 NVPKQSSQL 2594
>NP_940820
          Length = 887

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK +SQL
Sbjct: 800 NIPKDTSQL 808
>NP_001028776
          Length = 852

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK +SQL
Sbjct: 765 NIPKDTSQL 773
>NP_001028777
          Length = 882

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK +SQL
Sbjct: 795 NIPKDTSQL 803
>NP_055266
          Length = 847

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK +SQL
Sbjct: 760 NIPKDTSQL 768
>XP_006715751
          Length = 796

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK +SQL
Sbjct: 709 NIPKDTSQL 717
>XP_005249757
          Length = 886

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK +SQL
Sbjct: 800 NIPKDTSQL 808
>XP_006715750
          Length = 887

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK +SQL
Sbjct: 800 NIPKDTSQL 808
>NP_005711
          Length = 372

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NMPKQSSQ 8
           ++PKQSSQ
Sbjct: 286 DVPKQSSQ 293
>XP_006715889
          Length = 372

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NMPKQSSQ 8
           ++PKQSSQ
Sbjct: 286 DVPKQSSQ 293
>XP_006715888
          Length = 372

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   NMPKQSSQ 8
           ++PKQSSQ
Sbjct: 286 DVPKQSSQ 293
>NP_001265611
          Length = 275

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 44 NLPKESVQI 52
>NP_775299
          Length = 286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 55 NLPKESVQI 63
>NP_003235
          Length = 272

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 41 NLPKESVQI 49
>NP_775303
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 21 NLPKESVQI 29
>NP_775302
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 21 NLPKESVQI 29
>NP_775301
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 21 NLPKESVQI 29
>NP_001265615
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 21 NLPKESVQI 29
>NP_777480
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 21 NLPKESVQI 29
>NP_733796
          Length = 401

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N+PK+S Q+
Sbjct: 170 NLPKESVQI 178
>NP_001265613
          Length = 272

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 41 NLPKESVQI 49
>NP_775300
          Length = 272

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 41 NLPKESVQI 49
>NP_004923
          Length = 790

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NMPKQSSQL 9
           N PKQSS++
Sbjct: 464 NNPKQSSRV 472
>NP_057363
          Length = 789

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NMPKQSSQL 9
           N PKQSS +
Sbjct: 464 NNPKQSSHI 472
>XP_005258192
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NMPKQSSQL 9
          N+PK+S Q+
Sbjct: 21 NLPKESVQI 29
>NP_060682
          Length = 570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 120 LPRQNSQL 127
>NP_001008493
          Length = 591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 120 LPRQNSQL 127
>XP_005273239
          Length = 812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 134 LPRQNSQL 141
>XP_005273246
          Length = 547

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 134 LPRQNSQL 141
>XP_005273245
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 134 LPRQNSQL 141
>XP_006711860
          Length = 587

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 153 LPRQNSQL 160
>XP_006711859
          Length = 603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 153 LPRQNSQL 160
>XP_005273244
          Length = 605

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 134 LPRQNSQL 141
>XP_006711858
          Length = 624

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 153 LPRQNSQL 160
>XP_006711856
          Length = 806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 107 LPRQNSQL 114
>XP_006711855
          Length = 806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 107 LPRQNSQL 114
>XP_006711854
          Length = 819

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 120 LPRQNSQL 127
>XP_006711853
          Length = 825

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 126 LPRQNSQL 133
>XP_006711852
          Length = 831

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 153 LPRQNSQL 160
>XP_006711851
          Length = 833

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 134 LPRQNSQL 141
>XP_006711850
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 139 LPRQNSQL 146
>XP_006711849
          Length = 852

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MPKQSSQL 9
           +P+Q+SQL
Sbjct: 153 LPRQNSQL 160
>NP_065988
          Length = 2048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NMPKQSSQL 9
            N PK  SQL
Sbjct: 1473 NFPKPCSQL 1481
>NP_005235
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P QSS+
Sbjct: 210 NVPNQSSE 217
>NP_742108
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P QSS+
Sbjct: 210 NVPNQSSE 217
>NP_001185780
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P +SSQ
Sbjct: 315 NIPSESSQ 322
>NP_001185779
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P +SSQ
Sbjct: 315 NIPSESSQ 322
>NP_001185781
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P +SSQ
Sbjct: 281 NIPSESSQ 288
>NP_055762
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P +SSQ
Sbjct: 315 NIPSESSQ 322
>NP_057302
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N PK+SS+
Sbjct: 819 NQPKESSR 826
>XP_005267986
          Length = 2022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NMPKQSSQL 9
            N PK  SQL
Sbjct: 1447 NFPKPCSQL 1455
>XP_006714715
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N PK+SS+
Sbjct: 404 NQPKESSR 411
>XP_006714714
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N PK+SS+
Sbjct: 743 NQPKESSR 750
>XP_006714713
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N PK+SS+
Sbjct: 833 NQPKESSR 840
>XP_005248591
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N PK+SS+
Sbjct: 833 NQPKESSR 840
>XP_006710522
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P +SSQ
Sbjct: 289 NIPSESSQ 296
>XP_006710521
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P +SSQ
Sbjct: 300 NIPSESSQ 307
>XP_005270689
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMPKQSSQ 8
           N+P +SSQ
Sbjct: 323 NIPSESSQ 330
>NP_277045
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MPKQSSQL 9
           MPK  SQL
Sbjct: 157 MPKSYSQL 164
>NP_001004470
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MPKQSSQL 9
           MPK+ SQ+
Sbjct: 372 MPKEYSQI 379
>NP_060639
          Length = 1747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NMPKQSSQL 9
           NMP   SQL
Sbjct: 148 NMPALQSQL 156
>XP_006719162
          Length = 1676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NMPKQSSQL 9
           NMP   SQL
Sbjct: 148 NMPALQSQL 156
>XP_005253462
          Length = 1747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NMPKQSSQL 9
           NMP   SQL
Sbjct: 148 NMPALQSQL 156
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.108    0.272 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 537,105
Number of extensions: 482
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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