Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     299
NP_036462                                                              20     299
NP_001243397                                                           20     299
NP_001092882                                                           20     299
NP_006757                                                              20     299
NP_001092883                                                           20     299
XP_005269721                                                           20     299
XP_005273706                                                           20     299
NP_078966                                                              16    5631
NP_056432                                                              16    5631
XP_005254357                                                           16    5631
NP_002567                                                              16    7355
NP_001122092                                                           16    7355
NP_006097                                                              16    7355
NP_001269028                                                           16    7355
NP_115954                                                              16    7355
NP_001269026                                                           16    7355
NP_001269027                                                           16    7355
NP_055840                                                              16    7355
NP_000258                                                              16    7355
NP_001035957                                                           16    7355
XP_006721990                                                           16    7355
XP_006721989                                                           16    7355
XP_005258041                                                           16    7355
XP_006721988                                                           16    7355
XP_006721987                                                           16    7355
XP_006721986                                                           16    7355
XP_005258040                                                           16    7355
XP_006721985                                                           16    7355
XP_006718639                                                           16    7355
XP_006718638                                                           16    7355
XP_006718637                                                           16    7355
XP_006718636                                                           16    7355
XP_005274082                                                           16    7355
XP_006718635                                                           16    7355
XP_006711931                                                           16    7355
XP_006711930                                                           16    7355
XP_006711929                                                           16    7355
XP_006711928                                                           16    7355
XP_006711927                                                           16    7355
XP_006711926                                                           16    7355
XP_006711925                                                           16    7355
NP_003292                                                              15    9605
NP_001106853                                                           15    9605
XP_006712889                                                           15    9605
NP_803875                                                              15    9605
>NP_001243398
          Length = 1781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1693 NMNTLNAMN 1701
>NP_036462
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1985 NMNTLNAMN 1993
>NP_001243397
          Length = 1890

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1802 NMNTLNAMN 1810
>NP_001092882
          Length = 2004

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1915 NMNTLNAMN 1923
>NP_006757
          Length = 2004

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1915 NMNTLNAMN 1923
>NP_001092883
          Length = 2004

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1915 NMNTLNAMN 1923
>XP_005269721
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1985 NMNTLNAMN 1993
>XP_005273706
          Length = 1997

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NMNT NAMN
Sbjct: 1908 NMNTLNAMN 1916
>NP_078966
          Length = 14507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NMNTSNAMN 9
            NM T+N+M+
Sbjct: 6015 NMGTTNSMH 6023
>NP_056432
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NMNTSNAMN 9
           N+N +NA+N
Sbjct: 275 NVNRNNAVN 283
>XP_005254357
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NMNTSNAMN 9
           N+N +NA+N
Sbjct: 275 NVNRNNAVN 283
>NP_002567
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 154 NSSNALN 160
>NP_001122092
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 154 NSSNALN 160
>NP_006097
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MNTSNAMN 9
           MN+++AMN
Sbjct: 225 MNSASAMN 232
>NP_001269028
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MNTSNAMN 9
           MN+++AMN
Sbjct: 225 MNSASAMN 232
>NP_115954
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NMNTSN 6
           N+NTSN
Sbjct: 156 NLNTSN 161
>NP_001269026
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MNTSNAMN 9
           MN+++AMN
Sbjct: 225 MNSASAMN 232
>NP_001269027
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   MNTSNAMN 9
           MN+++AMN
Sbjct: 225 MNSASAMN 232
>NP_055840
          Length = 1184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>NP_000258
          Length = 2818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2754 NLNLSNSM 2761
>NP_001035957
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2775 NLNLSNSM 2782
>XP_006721990
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2785 NLNLSNSM 2792
>XP_006721989
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2785 NLNLSNSM 2792
>XP_005258041
          Length = 2836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2754 NLNLSNSM 2761
>XP_006721988
          Length = 2846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2764 NLNLSNSM 2771
>XP_006721987
          Length = 2849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2785 NLNLSNSM 2792
>XP_006721986
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2772 NLNLSNSM 2779
>XP_005258040
          Length = 2857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2775 NLNLSNSM 2782
>XP_006721985
          Length = 2867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NMNTSNAM 8
            N+N SN+M
Sbjct: 2785 NLNLSNSM 2792
>XP_006718639
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 154 NSSNALN 160
>XP_006718638
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 154 NSSNALN 160
>XP_006718637
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 154 NSSNALN 160
>XP_006718636
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 154 NSSNALN 160
>XP_005274082
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 154 NSSNALN 160
>XP_006718635
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTSNAMN 9
           N+SNA+N
Sbjct: 216 NSSNALN 222
>XP_006711931
          Length = 1162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>XP_006711930
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>XP_006711929
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>XP_006711928
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>XP_006711927
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>XP_006711926
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>XP_006711925
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NMNTSNAM 8
           N NTSN++
Sbjct: 226 NSNTSNSL 233
>NP_003292
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NMNTSN 6
           N+NTSN
Sbjct: 246 NVNTSN 251
>NP_001106853
          Length = 2093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NMNTSNA 7
            ++NTSNA
Sbjct: 2045 SLNTSNA 2051
>XP_006712889
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NMNTSNA 7
            ++NTSNA
Sbjct: 2021 SLNTSNA 2027
>NP_803875
          Length = 4243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NMNTSNAMN 9
           N  T+NA+N
Sbjct: 517 NWETTNAIN 525
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293   0.0966    0.244 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 360,359
Number of extensions: 686
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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