Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001162597                                                           18    1935
NP_653216                                                              18    1935
NP_072088                                                              17    3301
NP_001273596                                                           16    7355
NP_001273595                                                           16    7355
NP_001273594                                                           16    7355
NP_001129406                                                           16    7355
NP_001129407                                                           16    7355
NP_006466                                                              16    7355
NP_001129408                                                           16    7355
NP_001266282                                                           16    7355
NP_919255                                                              16    7355
NP_001266284                                                           16    7355
NP_009190                                                              16    7355
NP_001266283                                                           16    7355
XP_005255358                                                           16    7355
XP_005255357                                                           16    7355
XP_005255356                                                           16    7355
XP_005255355                                                           16    7355
XP_005266289                                                           16    7355
XP_005266288                                                           16    7355
XP_006719746                                                           16    7355
XP_005253685                                                           16    7355
XP_005253684                                                           16    7355
XP_006711205                                                           16    7355
NP_001138483                                                           16    7355
NP_003950                                                              16    7355
NP_060791                                                              16    7355
NP_001034930                                                           15    9605
NP_079124                                                              15    9605
NP_001273409                                                           15    9605
NP_055598                                                              15    9605
NP_002635                                                              15    9605
NP_619520                                                              15    9605
NP_055781                                                              15    9605
NP_055918                                                              15    9605
NP_955389                                                              15    9605
NP_001273408                                                           15    9605
XP_006725628                                                           15    9605
XP_006725627                                                           15    9605
XP_006720851                                                           15    9605
XP_005254865                                                           15    9605
XP_006713096                                                           15    9605
XP_006713095                                                           15    9605
XP_005273220                                                           15    9605
XP_005244856                                                           15    9605
XP_006710969                                                           15    9605
XP_005244855                                                           15    9605
>NP_001162597
          Length = 278

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  NLLEVSQGS 9
          NLL+V QGS
Sbjct: 30 NLLQVRQGS 38
>NP_653216
          Length = 282

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  NLLEVSQGS 9
          NLL+V QGS
Sbjct: 30 NLLQVRQGS 38
>NP_072088
          Length = 362

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LLEVSQG 8
           LLEVSQG
Sbjct: 180 LLEVSQG 186
>NP_001273596
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>NP_001273595
          Length = 749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>NP_001273594
          Length = 809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>NP_001129406
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>NP_001129407
          Length = 781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>NP_006466
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>NP_001129408
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>NP_001266282
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NLLEVSQ 7
           NLLEVS+
Sbjct: 241 NLLEVSE 247
>NP_919255
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LLEVSQGS 9
          LLE+++GS
Sbjct: 60 LLEITEGS 67
>NP_001266284
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NLLEVSQ 7
           NLLEVS+
Sbjct: 223 NLLEVSE 229
>NP_009190
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NLLEVSQ 7
           NLLEVS+
Sbjct: 346 NLLEVSE 352
>NP_001266283
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NLLEVSQ 7
           NLLEVS+
Sbjct: 310 NLLEVSE 316
>XP_005255358
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLEVSQGS 9
           LLE SQG+
Sbjct: 107 LLEASQGT 114
>XP_005255357
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLEVSQGS 9
           LLE SQG+
Sbjct: 107 LLEASQGT 114
>XP_005255356
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLEVSQGS 9
           LLE SQG+
Sbjct: 107 LLEASQGT 114
>XP_005255355
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLEVSQGS 9
           LLE SQG+
Sbjct: 107 LLEASQGT 114
>XP_005266289
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>XP_005266288
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L+ +QGS
Sbjct: 583 NILKTTQGS 591
>XP_006719746
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NL+E+S G
Sbjct: 305 NLIEISTG 312
>XP_005253685
          Length = 1061

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NL+E+S G
Sbjct: 305 NLIEISTG 312
>XP_005253684
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NL+E+S G
Sbjct: 317 NLIEISTG 324
>XP_006711205
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NLLEVSQ 7
           NLLEVS+
Sbjct: 346 NLLEVSE 352
>NP_001138483
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLEVSQGS 9
           LLE SQG+
Sbjct: 107 LLEASQGT 114
>NP_003950
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NL+E+S G
Sbjct: 317 NLIEISTG 324
>NP_060791
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           NL+++ QGS
Sbjct: 239 NLIKIFQGS 247
>NP_001034930
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NLL+ S+G
Sbjct: 202 NLLQTSEG 209
>NP_079124
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLEVSQGS 9
           ++EV+QGS
Sbjct: 224 VMEVAQGS 231
>NP_001273409
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  NLLEVSQG 8
          NLL+ S+G
Sbjct: 13 NLLQTSEG 20
>NP_055598
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NLL+ S+G
Sbjct: 202 NLLQTSEG 209
>NP_002635
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LEVSQG 8
           LEVSQG
Sbjct: 125 LEVSQG 130
>NP_619520
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLLEVSQG 8
            NL++V QG
Sbjct: 1026 NLIQVRQG 1033
>NP_055781
          Length = 1155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NL++V QG
Sbjct: 987 NLIQVRQG 994
>NP_055918
          Length = 1925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NLLEVSQGS 9
           N+L++ QG+
Sbjct: 263 NILKIKQGA 271
>NP_955389
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NLL+ S+G
Sbjct: 202 NLLQTSEG 209
>NP_001273408
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  NLLEVSQG 8
          NLL+ S+G
Sbjct: 13 NLLQTSEG 20
>XP_006725628
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NLL+ S+G
Sbjct: 202 NLLQTSEG 209
>XP_006725627
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NLL+ S+G
Sbjct: 202 NLLQTSEG 209
>XP_006720851
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  NLLEVSQG 8
          NLL+ S+G
Sbjct: 13 NLLQTSEG 20
>XP_005254865
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLLEVSQG 8
           NLL+ S+G
Sbjct: 202 NLLQTSEG 209
>XP_006713096
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLLEVSQG 8
            NL++V QG
Sbjct: 994  NLIQVRQG 1001
>XP_006713095
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NLLEVSQG 8
            NL++V QG
Sbjct: 1054 NLIQVRQG 1061
>XP_005273220
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LEVSQG 8
           LEVSQG
Sbjct: 125 LEVSQG 130
>XP_005244856
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLEVSQGS 9
           ++EV+QGS
Sbjct: 224 VMEVAQGS 231
>XP_006710969
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLEVSQGS 9
           ++EV+QGS
Sbjct: 224 VMEVAQGS 231
>XP_005244855
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLEVSQGS 9
           ++EV+QGS
Sbjct: 200 VMEVAQGS 207
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.120    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 451,978
Number of extensions: 721
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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