Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_114432                                                              18    1135
NP_055845                                                              17    4312
NP_075463                                                              17    4312
NP_065789                                                              17    4312
XP_006719812                                                           17    4312
XP_005248150                                                           17    4312
XP_005248148                                                           17    4312
XP_005248147                                                           17    4312
XP_005248145                                                           17    4312
XP_005248144                                                           17    4312
XP_005248143                                                           17    4312
XP_005248142                                                           17    4312
XP_005248141                                                           17    4312
XP_005248140                                                           17    4312
XP_005248139                                                           17    4312
NP_065813                                                              16    5631
NP_006382                                                              16    5631
XP_005269099                                                           16    5631
NP_057287                                                              16    7355
NP_055665                                                              16    7355
NP_077747                                                              16    7355
NP_001035723                                                           16    7355
NP_001028289                                                           16    7355
NP_004617                                                              16    7355
NP_932069                                                              16    7355
XP_005274288                                                           16    7355
XP_005250066                                                           16    7355
XP_005250064                                                           16    7355
XP_005250063                                                           16    7355
XP_005250062                                                           16    7355
XP_005250061                                                           16    7355
XP_006716084                                                           16    7355
XP_005250060                                                           16    7355
XP_005250059                                                           16    7355
XP_006713496                                                           16    7355
XP_005265679                                                           16    7355
NP_056141                                                              15    9605
NP_003194                                                              15    9605
NP_001164108                                                           15    9605
NP_001188263                                                           15    9605
NP_596870                                                              15    9605
NP_689716                                                              15    9605
NP_001106271                                                           15    9605
NP_066920                                                              15    9605
NP_066363                                                              15    9605
NP_998797                                                              15    9605
NP_998796                                                              15    9605
XP_006723899                                                           15    9605
XP_005264578                                                           15    9605
XP_005264577                                                           15    9605
XP_006712148                                                           15    9605
XP_006712147                                                           15    9605
XP_006712146                                                           15    9605
XP_006712145                                                           15    9605
XP_006712144                                                           15    9605
XP_006712143                                                           15    9605
XP_005264569                                                           15    9605
XP_005277572                                                           15    9605
XP_005277571                                                           15    9605
XP_006711310                                                           15    9605
XP_005277570                                                           15    9605
XP_005277569                                                           15    9605
XP_006711309                                                           15    9605
XP_005277568                                                           15    9605
XP_005277567                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NLEIIKTIV 9
            NLEIIKT+V
Sbjct: 2234 NLEIIKTLV 2242
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NLEIIKTIV 9
            NLEIIKT+V
Sbjct: 2234 NLEIIKTLV 2242
>NP_114432
          Length = 1249

 Score = 18.5 bits (36), Expect =  1135
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   NLEIIKTIV 9
           NLE++KT++
Sbjct: 716 NLELVKTVI 724
>NP_055845
          Length = 3013

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2223 NLEIIKII 2230
>NP_075463
          Length = 3013

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NLEIIKTI 8
            N+E++KTI
Sbjct: 2264 NVEVLKTI 2271
>NP_065789
          Length = 1771

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NLEIIKTIV 9
          NLEI+K ++
Sbjct: 50 NLEIVKELI 58
>XP_006719812
          Length = 3019

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    NLEIIKTI 8
            N+E++KTI
Sbjct: 2261 NVEVLKTI 2268
>XP_005248150
          Length = 2044

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 1254 NLEIIKII 1261
>XP_005248148
          Length = 3028

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2238 NLEIIKII 2245
>XP_005248147
          Length = 3028

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2238 NLEIIKII 2245
>XP_005248145
          Length = 3079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2289 NLEIIKII 2296
>XP_005248144
          Length = 3099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2315 NLEIIKII 2322
>XP_005248143
          Length = 3105

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2315 NLEIIKII 2322
>XP_005248142
          Length = 3114

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2330 NLEIIKII 2337
>XP_005248141
          Length = 3119

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2329 NLEIIKII 2336
>XP_005248140
          Length = 3119

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2329 NLEIIKII 2336
>XP_005248139
          Length = 3120

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    NLEIIKTI 8
            NLEIIK I
Sbjct: 2330 NLEIIKII 2337
>NP_065813
          Length = 1085

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           EIIKTI+
Sbjct: 681 EIIKTII 687
>NP_006382
          Length = 1038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           +EI+KT+V
Sbjct: 229 IEILKTVV 236
>XP_005269099
          Length = 1062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           EIIKTI+
Sbjct: 658 EIIKTII 664
>NP_057287
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 514 LEILETIV 521
>NP_055665
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 681 EVIKTII 687
>NP_077747
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 273 LEILETIV 280
>NP_001035723
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 470 LEILETIV 477
>NP_001028289
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 657 EVIKTII 663
>NP_004617
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NLEIIKTIV 9
          NLE++ T+V
Sbjct: 62 NLELMHTVV 70
>NP_932069
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NLEIIKTIV 9
          NLE++ T+V
Sbjct: 29 NLELVFTVV 37
>XP_005274288
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NLEIIKTIV 9
          NLE++ T+V
Sbjct: 62 NLELMHTVV 70
>XP_005250066
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 253 LEILETIV 260
>XP_005250064
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 389 LEILETIV 396
>XP_005250063
          Length = 495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 390 LEILETIV 397
>XP_005250062
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 513 LEILETIV 520
>XP_005250061
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 470 LEILETIV 477
>XP_006716084
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 510 LEILETIV 517
>XP_005250060
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 513 LEILETIV 520
>XP_005250059
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEIIKTIV 9
           LEI++TIV
Sbjct: 514 LEILETIV 521
>XP_006713496
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 173 EVIKTII 179
>XP_005265679
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 681 EVIKTII 687
>NP_056141
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 666 ELIKTII 672
>NP_003194
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NLEIIK 6
           NLEIIK
Sbjct: 267 NLEIIK 272
>NP_001164108
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 665 ELIKTII 671
>NP_001188263
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NLEIIK 6
           NLEIIK
Sbjct: 98  NLEIIK 103
>NP_596870
          Length = 5604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    NLEIIKT 7
            NL+I+KT
Sbjct: 4711 NLDILKT 4717
>NP_689716
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NLEIIK 6
           NLEIIK
Sbjct: 122 NLEIIK 127
>NP_001106271
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 599 NDEIVKTI 606
>NP_066920
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 599 NDEIVKTI 606
>NP_066363
          Length = 1918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLEIIKTIV 9
           NLE ++TI+
Sbjct: 294 NLEKVQTII 302
>NP_998797
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NLEIIK 6
           NLEIIK
Sbjct: 122 NLEIIK 127
>NP_998796
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NLEIIK 6
           NLEIIK
Sbjct: 122 NLEIIK 127
>XP_006723899
          Length = 1918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLEIIKTIV 9
           NLE ++TI+
Sbjct: 294 NLEKVQTII 302
>XP_005264578
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NLEIIK 6
           NLEIIK
Sbjct: 275 NLEIIK 280
>XP_005264577
          Length = 789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NLEIIK 6
           NLEIIK
Sbjct: 275 NLEIIK 280
>XP_006712148
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 599 NDEIVKTI 606
>XP_006712147
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 599 NDEIVKTI 606
>XP_006712146
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 599 NDEIVKTI 606
>XP_006712145
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 599 NDEIVKTI 606
>XP_006712144
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 599 NDEIVKTI 606
>XP_006712143
          Length = 996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 622 NDEIVKTI 629
>XP_005264569
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NLEIIKTI 8
           N EI+KTI
Sbjct: 629 NDEIVKTI 636
>XP_005277572
          Length = 789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 665 ELIKTII 671
>XP_005277571
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 666 ELIKTII 672
>XP_006711310
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 666 ELIKTII 672
>XP_005277570
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 513 ELIKTII 519
>XP_005277569
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 513 ELIKTII 519
>XP_006711309
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 666 ELIKTII 672
>XP_005277568
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 665 ELIKTII 671
>XP_005277567
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EIIKTIV 9
           E+IKTI+
Sbjct: 666 ELIKTII 672
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.146    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 369,176
Number of extensions: 589
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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