Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     665
XP_005262424                                                           19     665
NP_004817                                                              17    3301
NP_001277716                                                           17    3301
NP_001269891                                                           17    4312
NP_060880                                                              17    4312
NP_001269892                                                           17    4312
NP_003766                                                              17    4312
NP_002151                                                              16    5631
NP_079350                                                              16    5631
NP_055785                                                              16    5631
NP_001191443                                                           16    5631
NP_001191446                                                           16    5631
NP_001191445                                                           16    5631
XP_003960172                                                           16    5631
XP_006717160                                                           16    5631
XP_006717159                                                           16    5631
XP_006714380                                                           16    5631
XP_006714379                                                           16    5631
XP_006714378                                                           16    5631
XP_006714377                                                           16    5631
XP_005245027                                                           16    5631
XP_003119008                                                           16    5631
XP_003119853                                                           16    5631
NP_004381                                                              16    7355
NP_060362                                                              16    7355
XP_003960128                                                           16    7355
XP_006720541                                                           16    7355
XP_005254378                                                           16    7355
XP_005254377                                                           16    7355
XP_005254238                                                           16    7355
XP_005246736                                                           16    7355
XP_005246735                                                           16    7355
XP_005246734                                                           16    7355
XP_005246733                                                           16    7355
NP_954980                                                              16    7355
NP_658986                                                              15    9605
NP_078858                                                              15    9605
NP_001278232                                                           15    9605
NP_001278214                                                           15    9605
NP_001155056                                                           15    9605
NP_060216                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_003746                                                              15    9605
NP_620414                                                              15    9605
XP_005260720                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NLANITISD 9
            +LANITISD
Sbjct: 2457 DLANITISD 2465
>XP_005262424
          Length = 2875

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NLANITISD 9
            +LANITISD
Sbjct: 2252 DLANITISD 2260
>NP_004817
          Length = 775

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LANITISD 9
           LANIT+S+
Sbjct: 320 LANITVSE 327
>NP_001277716
          Length = 773

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LANITISD 9
           LANIT+S+
Sbjct: 320 LANITVSE 327
>NP_001269891
          Length = 694

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLANITISD 9
           ++ N+TISD
Sbjct: 200 DICNVTISD 208
>NP_060880
          Length = 748

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLANITISD 9
           ++ N+TISD
Sbjct: 254 DICNVTISD 262
>NP_001269892
          Length = 663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NLANITISD 9
           ++ N+TISD
Sbjct: 169 DICNVTISD 177
>NP_003766
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LANITISD 9
          L NIT+SD
Sbjct: 85 LVNITLSD 92
>NP_002151
          Length = 2201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L N+TISD
Sbjct: 1532 LENLTISD 1539
>NP_079350
          Length = 4012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NLANITISD 9
            N+A ITIS+
Sbjct: 3027 NMATITISN 3035
>NP_055785
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           LAN+TI D
Sbjct: 528 LANLTIPD 535
>NP_001191443
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           LAN+TI D
Sbjct: 450 LANLTIPD 457
>NP_001191446
          Length = 752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           LAN+TI D
Sbjct: 488 LANLTIPD 495
>NP_001191445
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           LAN+TI D
Sbjct: 484 LANLTIPD 491
>XP_003960172
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           NLANIT S
Sbjct: 389 NLANITDS 396
>XP_006717160
          Length = 2110

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L N+TISD
Sbjct: 1441 LENLTISD 1448
>XP_006717159
          Length = 2293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L N+TISD
Sbjct: 1624 LENLTISD 1631
>XP_006714380
          Length = 3897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NLANITISD 9
            N+A ITIS+
Sbjct: 2912 NMATITISN 2920
>XP_006714379
          Length = 3936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NLANITISD 9
            N+A ITIS+
Sbjct: 2951 NMATITISN 2959
>XP_006714378
          Length = 3965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NLANITISD 9
            N+A ITIS+
Sbjct: 2980 NMATITISN 2988
>XP_006714377
          Length = 4010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NLANITISD 9
            N+A ITIS+
Sbjct: 3025 NMATITISN 3033
>XP_005245027
          Length = 794

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           LAN+TI D
Sbjct: 528 LANLTIPD 535
>XP_003119008
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           NLANIT S
Sbjct: 389 NLANITDS 396
>XP_003119853
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           NLANIT S
Sbjct: 389 NLANITDS 396
>NP_004381
          Length = 335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NLANITISD 9
           ++ANITI D
Sbjct: 227 DVANITIYD 235
>NP_060362
          Length = 930

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           N+AN+T S
Sbjct: 513 NMANVTYS 520
>XP_003960128
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NLANITIS 8
          NL+N+TI+
Sbjct: 41 NLSNLTIN 48
>XP_006720541
          Length = 123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NLANITIS 8
          NLA++T+S
Sbjct: 13 NLASVTLS 20
>XP_005254378
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NLANITIS 8
          NLA++T+S
Sbjct: 30 NLASVTLS 37
>XP_005254377
          Length = 231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NLANITIS 8
           NLA++T+S
Sbjct: 121 NLASVTLS 128
>XP_005254238
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NLANITISD 9
           ++ANITI D
Sbjct: 189 DVANITIYD 197
>XP_005246736
          Length = 976

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           N+AN+T S
Sbjct: 555 NMANVTYS 562
>XP_005246735
          Length = 976

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           N+AN+T S
Sbjct: 555 NMANVTYS 562
>XP_005246734
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           N+AN+T S
Sbjct: 513 NMANVTYS 520
>XP_005246733
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NLANITIS 8
           N+AN+T S
Sbjct: 555 NMANVTYS 562
>NP_954980
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NLANITIS 8
          NL+N+TI+
Sbjct: 40 NLSNLTIN 47
>NP_658986
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LANITISD 9
          +AN+ ISD
Sbjct: 92 IANLAISD 99
>NP_078858
          Length = 4981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    NITISD 9
            NIT+SD
Sbjct: 1828 NITVSD 1833
>NP_001278232
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    NITISD 9
            NIT+SD
Sbjct: 1828 NITVSD 1833
>NP_001278214
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    NITISD 9
            NIT+SD
Sbjct: 1828 NITVSD 1833
>NP_001155056
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           L N+T+SD
Sbjct: 435 LLNLTLSD 442
>NP_060216
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           L N+T+SD
Sbjct: 432 LLNLTLSD 439
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L+N+TI D
Sbjct: 4537 LSNLTIQD 4544
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L+N+TI D
Sbjct: 3610 LSNLTIQD 3617
>NP_003746
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NLANITISD 9
           N+A  T+SD
Sbjct: 116 NVATTTVSD 124
>NP_620414
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LANITISD 9
           +AN+ ISD
Sbjct: 101 IANLAISD 108
>XP_005260720
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LANITISD 9
          +AN+ ISD
Sbjct: 92 IANLAISD 99
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L+N+TI D
Sbjct: 4538 LSNLTIQD 4545
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L+N+TI D
Sbjct: 4538 LSNLTIQD 4545
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LANITISD 9
            L+N+TI D
Sbjct: 4854 LSNLTIQD 4861
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.126    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 302,357
Number of extensions: 344
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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