Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     665
XP_006718908                                                           19     665
XP_005271621                                                           19     665
XP_006718907                                                           19     665
XP_006718906                                                           19     665
XP_005271619                                                           19     665
XP_005271618                                                           19     665
NP_942133                                                              18    1935
NP_942131                                                              18    1935
NP_942134                                                              18    1935
NP_942135                                                              18    1935
NP_942136                                                              18    1935
XP_006725384                                                           18    1935
XP_006725383                                                           18    1935
XP_005257324                                                           18    1935
XP_005257323                                                           18    1935
XP_006721916                                                           18    1935
NP_037393                                                              15    9605
NP_055873                                                              15    9605
NP_001009814                                                           15    9605
NP_001119576                                                           15    9605
NP_037409                                                              15    9605
NP_001119575                                                           15    9605
NP_006150                                                              15    9605
NP_001138582                                                           15    9605
NP_001138581                                                           15    9605
NP_001138580                                                           15    9605
NP_001138579                                                           15    9605
NP_055646                                                              15    9605
XP_006719855                                                           15    9605
XP_006719854                                                           15    9605
XP_006719853                                                           15    9605
XP_005268962                                                           15    9605
XP_006719423                                                           15    9605
XP_006719422                                                           15    9605
XP_005268873                                                           15    9605
XP_005268872                                                           15    9605
XP_005268870                                                           15    9605
XP_005268871                                                           15    9605
XP_005268869                                                           15    9605
XP_005268868                                                           15    9605
XP_005248191                                                           15    9605
XP_005248189                                                           15    9605
XP_005248188                                                           15    9605
XP_005248187                                                           15    9605
XP_006713495                                                           15    9605
>NP_000042
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NKVVERVLM 9
            NKV ERVLM
Sbjct: 3003 NKVAERVLM 3011
>XP_006718908
          Length = 1708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NKVVERVLM 9
            NKV ERVLM
Sbjct: 1655 NKVAERVLM 1663
>XP_005271621
          Length = 2708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NKVVERVLM 9
            NKV ERVLM
Sbjct: 2655 NKVAERVLM 2663
>XP_006718907
          Length = 3050

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NKVVERVLM 9
            NKV ERVLM
Sbjct: 2997 NKVAERVLM 3005
>XP_006718906
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NKVVERVLM 9
            NKV ERVLM
Sbjct: 3003 NKVAERVLM 3011
>XP_005271619
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NKVVERVLM 9
            NKV ERVLM
Sbjct: 3003 NKVAERVLM 3011
>XP_005271618
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    NKVVERVLM 9
            NKV ERVLM
Sbjct: 3003 NKVAERVLM 3011
>NP_942133
          Length = 2346

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKVVERVLM 9
           NKV+E+VL+
Sbjct: 115 NKVIEKVLI 123
>NP_942131
          Length = 2383

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKVVERVLM 9
           NKV+E+VL+
Sbjct: 152 NKVIEKVLI 160
>NP_942134
          Length = 2288

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  NKVVERVLM 9
          NKV+E+VL+
Sbjct: 57 NKVIEKVLI 65
>NP_942135
          Length = 2268

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  NKVVERVLM 9
          NKV+E+VL+
Sbjct: 37 NKVIEKVLI 45
>NP_942136
          Length = 2346

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKVVERVLM 9
           NKV+E+VL+
Sbjct: 115 NKVIEKVLI 123
>XP_006725384
          Length = 2268

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  NKVVERVLM 9
          NKV+E+VL+
Sbjct: 37 NKVIEKVLI 45
>XP_006725383
          Length = 2338

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKVVERVLM 9
           NKV+E+VL+
Sbjct: 115 NKVIEKVLI 123
>XP_005257324
          Length = 2268

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  NKVVERVLM 9
          NKV+E+VL+
Sbjct: 37 NKVIEKVLI 45
>XP_005257323
          Length = 2268

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  NKVVERVLM 9
          NKV+E+VL+
Sbjct: 37 NKVIEKVLI 45
>XP_006721916
          Length = 2375

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKVVERVLM 9
           NKV+E+VL+
Sbjct: 152 NKVIEKVLI 160
>NP_037393
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKVVERVL 8
           NK +ER L
Sbjct: 277 NKTIERTL 284
>NP_055873
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+V+R L
Sbjct: 788 NKIVDRFL 795
>NP_001009814
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+V+R L
Sbjct: 788 NKIVDRFL 795
>NP_001119576
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>NP_037409
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>NP_001119575
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>NP_006150
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+ ERV+
Sbjct: 169 NKIYERVV 176
>NP_001138582
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+ ERV+
Sbjct: 192 NKIYERVV 199
>NP_001138581
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+ ERV+
Sbjct: 168 NKIYERVV 175
>NP_001138580
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+ ERV+
Sbjct: 169 NKIYERVV 176
>NP_001138579
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+ ERV+
Sbjct: 219 NKIYERVV 226
>NP_055646
          Length = 2925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    KVVERVLM 9
            KVV+RVL+
Sbjct: 2569 KVVKRVLV 2576
>XP_006719855
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+V+R L
Sbjct: 788 NKIVDRFL 795
>XP_006719854
          Length = 1550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+V+R L
Sbjct: 433 NKIVDRFL 440
>XP_006719853
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+V+R L
Sbjct: 692 NKIVDRFL 699
>XP_005268962
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NKVVERVL 8
           NK+ ERV+
Sbjct: 169 NKIYERVV 176
>XP_006719423
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>XP_006719422
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>XP_005268873
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>XP_005268872
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>XP_005268870
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>XP_005268871
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>XP_005268869
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 526 KVVERLL 532
>XP_005268868
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVVERVL 8
           KVVER+L
Sbjct: 545 KVVERLL 551
>XP_005248191
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKVVERVL 8
           NK +ER L
Sbjct: 282 NKTIERTL 289
>XP_005248189
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKVVERVL 8
           NK +ER L
Sbjct: 274 NKTIERTL 281
>XP_005248188
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKVVERVL 8
           NK +ER L
Sbjct: 281 NKTIERTL 288
>XP_005248187
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKVVERVL 8
           NK +ER L
Sbjct: 282 NKTIERTL 289
>XP_006713495
          Length = 2969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    KVVERVLM 9
            KVV+RVL+
Sbjct: 2613 KVVKRVLV 2620
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.137    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 320,714
Number of extensions: 405
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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