Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001244126                                                           20     509
NP_003581                                                              20     509
NP_001244127                                                           20     509
XP_006712863                                                           20     509
NP_001182741                                                           17    3301
NP_689879                                                              17    3301
NP_001182740                                                           17    3301
NP_055699                                                              17    3301
NP_001017392                                                           17    3301
NP_005848                                                              17    3301
XP_006711815                                                           17    3301
NP_000204                                                              17    4312
NP_001136068                                                           17    4312
NP_000908                                                              17    4312
NP_001136067                                                           17    4312
NP_001017962                                                           17    4312
NP_001265524                                                           17    4312
NP_877577                                                              17    4312
NP_005907                                                              17    4312
XP_005257368                                                           17    4312
XP_006721932                                                           17    4312
XP_006721930                                                           17    4312
XP_005257366                                                           17    4312
XP_006721929                                                           17    4312
XP_005250405                                                           17    4312
NP_597677                                                              16    5631
NP_056199                                                              16    5631
XP_005248340                                                           16    5631
XP_005248339                                                           16    5631
XP_005248337                                                           16    5631
XP_006714531                                                           16    5631
XP_006714530                                                           16    5631
NP_000121                                                              16    7355
NP_002903                                                              16    7355
NP_001273361                                                           16    7355
NP_001273360                                                           16    7355
NP_891550                                                              16    7355
NP_001244896                                                           16    7355
NP_001244897                                                           16    7355
NP_940969                                                              16    7355
NP_919276                                                              16    7355
XP_005249718                                                           16    7355
XP_005267148                                                           16    7355
XP_005267147                                                           16    7355
XP_006715607                                                           16    7355
XP_006715606                                                           16    7355
XP_005265966                                                           16    7355
XP_005265386                                                           16    7355
NP_073585                                                              15    9605
NP_899662                                                              15    9605
NP_002886                                                              15    9605
NP_736610                                                              15    9605
NP_072174                                                              15    9605
NP_938072                                                              15    9605
NP_872363                                                              15    9605
XP_006726853                                                           15    9605
XP_006723905                                                           15    9605
XP_006723596                                                           15    9605
XP_006719367                                                           15    9605
XP_006719366                                                           15    9605
XP_006719365                                                           15    9605
XP_005271570                                                           15    9605
XP_005271569                                                           15    9605
XP_006718878                                                           15    9605
XP_005271568                                                           15    9605
XP_005246882                                                           15    9605
XP_006712784                                                           15    9605
NP_056134                                                              15    9605
>NP_001244126
          Length = 702

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NKSVSDDS 8
           NKSVSDDS
Sbjct: 377 NKSVSDDS 384
>NP_003581
          Length = 768

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NKSVSDDS 8
           NKSVSDDS
Sbjct: 443 NKSVSDDS 450
>NP_001244127
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NKSVSDDS 8
           NKSVSDDS
Sbjct: 449 NKSVSDDS 456
>XP_006712863
          Length = 795

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NKSVSDDS 8
           NKSVSDDS
Sbjct: 470 NKSVSDDS 477
>NP_001182741
          Length = 328

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NKSVSDDSG 9
           NK+ +DD+G
Sbjct: 313 NKTATDDTG 321
>NP_689879
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NKSVSDDSG 9
           NK+ +DD+G
Sbjct: 521 NKTATDDTG 529
>NP_001182740
          Length = 474

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NKSVSDDSG 9
           NK+ +DD+G
Sbjct: 459 NKTATDDTG 467
>NP_055699
          Length = 1082

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NKSVSDDS 8
           N S+SDDS
Sbjct: 94  NPSISDDS 101
>NP_001017392
          Length = 1082

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NKSVSDDS 8
           N S+SDDS
Sbjct: 94  NPSISDDS 101
>NP_005848
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NKSVSDDSG 9
           NK + +DSG
Sbjct: 291 NKDIQEDSG 299
>XP_006711815
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NKSVSDDSG 9
           NK+ +DD+G
Sbjct: 521 NKTATDDTG 529
>NP_000204
          Length = 1822

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SVSDDSG 9
            SVSDD+G
Sbjct: 1364 SVSDDTG 1370
>NP_001136068
          Length = 516

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NKSVSDD 7
           NKS SDD
Sbjct: 259 NKSASDD 265
>NP_000908
          Length = 534

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NKSVSDD 7
           NKS SDD
Sbjct: 259 NKSASDD 265
>NP_001136067
          Length = 534

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NKSVSDD 7
           NKS SDD
Sbjct: 259 NKSASDD 265
>NP_001017962
          Length = 534

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NKSVSDD 7
           NKS SDD
Sbjct: 259 NKSASDD 265
>NP_001265524
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKSVSDDSG 9
           NKS  D+SG
Sbjct: 131 NKSEDDESG 139
>NP_877577
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKSVSDDSG 9
           NKS  D+SG
Sbjct: 131 NKSEDDESG 139
>NP_005907
          Length = 719

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKSVSDDSG 9
           NKS  D+SG
Sbjct: 307 NKSEDDESG 315
>XP_005257368
          Length = 1875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SVSDDSG 9
            SVSDD+G
Sbjct: 1364 SVSDDTG 1370
>XP_006721932
          Length = 1821

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SVSDDSG 9
            SVSDD+G
Sbjct: 1310 SVSDDTG 1316
>XP_006721930
          Length = 1857

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SVSDDSG 9
            SVSDD+G
Sbjct: 1399 SVSDDTG 1405
>XP_005257366
          Length = 1875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SVSDDSG 9
            SVSDD+G
Sbjct: 1364 SVSDDTG 1370
>XP_006721929
          Length = 1910

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    SVSDDSG 9
            SVSDD+G
Sbjct: 1399 SVSDDTG 1405
>XP_005250405
          Length = 612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKSVSDDSG 9
           NKS  D+SG
Sbjct: 200 NKSEDDESG 208
>NP_597677
          Length = 2804

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NKSVSDDSG 9
           NK  SDD G
Sbjct: 820 NKQKSDDRG 828
>NP_056199
          Length = 2697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NKSVSDDSG 9
           NK  SDD G
Sbjct: 820 NKQKSDDRG 828
>XP_005248340
          Length = 2265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NKSVSDDSG 9
           NK  SDD G
Sbjct: 281 NKQKSDDRG 289
>XP_005248339
          Length = 2584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NKSVSDDSG 9
           NK  SDD G
Sbjct: 600 NKQKSDDRG 608
>XP_005248337
          Length = 2698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NKSVSDDSG 9
           NK  SDD G
Sbjct: 820 NKQKSDDRG 828
>XP_006714531
          Length = 2738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NKSVSDDSG 9
           NK  SDD G
Sbjct: 820 NKQKSDDRG 828
>XP_006714530
          Length = 2755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NKSVSDDSG 9
           NK  SDD G
Sbjct: 820 NKQKSDDRG 828
>NP_000121
          Length = 2224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVSDDSG 9
           S+S+DSG
Sbjct: 153 SISEDSG 159
>NP_002903
          Length = 3130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKSVSDDS 8
            + SVSDDS
Sbjct: 1613 DNSVSDDS 1620
>NP_001273361
          Length = 3052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKSVSDDS 8
            + SVSDDS
Sbjct: 1535 DNSVSDDS 1542
>NP_001273360
          Length = 3052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKSVSDDS 8
            + SVSDDS
Sbjct: 1535 DNSVSDDS 1542
>NP_891550
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVSDDSG 9
           S+S+DSG
Sbjct: 419 SISEDSG 425
>NP_001244896
          Length = 1054

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KSVSDDSG 9
           KSVS DSG
Sbjct: 791 KSVSLDSG 798
>NP_001244897
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KSVSDDSG 9
           KSVS DSG
Sbjct: 807 KSVSLDSG 814
>NP_940969
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VSDDSG 9
          +SDDSG
Sbjct: 7  ISDDSG 12
>NP_919276
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KSVSDDSG 9
           KSVS DSG
Sbjct: 781 KSVSLDSG 788
>XP_005249718
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KSVSDDSG 9
           KSVS DSG
Sbjct: 689 KSVSLDSG 696
>XP_005267148
          Length = 2679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKSVSDDS 8
            + SVSDDS
Sbjct: 1613 DNSVSDDS 1620
>XP_005267147
          Length = 2689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKSVSDDS 8
            + SVSDDS
Sbjct: 1613 DNSVSDDS 1620
>XP_006715607
          Length = 3052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKSVSDDS 8
            + SVSDDS
Sbjct: 1535 DNSVSDDS 1542
>XP_006715606
          Length = 3130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKSVSDDS 8
            + SVSDDS
Sbjct: 1613 DNSVSDDS 1620
>XP_005265966
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VSDDSG 9
          +SDDSG
Sbjct: 7  ISDDSG 12
>XP_005265386
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVSDDSG 9
           S+S+DSG
Sbjct: 391 SISEDSG 397
>NP_073585
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 388 SVSSDSG 394
>NP_899662
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NKSVSDD 7
           NK+++DD
Sbjct: 895 NKNINDD 901
>NP_002886
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NKSVSDD 7
           NK+++DD
Sbjct: 895 NKNINDD 901
>NP_736610
          Length = 1409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 508 SVSSDSG 514
>NP_072174
          Length = 1735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 401 SVSSDSG 407
>NP_938072
          Length = 1285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 384 SVSSDSG 390
>NP_872363
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NKSVSDDSG 9
           ++SVS DSG
Sbjct: 114 DRSVSVDSG 122
>XP_006726853
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KSVSDDS 8
           KS+S+DS
Sbjct: 125 KSISEDS 131
>XP_006723905
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NKSVSDD 7
           NK+++DD
Sbjct: 723 NKNINDD 729
>XP_006723596
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KSVSDDS 8
           KS+S+DS
Sbjct: 125 KSISEDS 131
>XP_006719367
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 527 SVSSDSG 533
>XP_006719366
          Length = 1418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 517 SVSSDSG 523
>XP_006719365
          Length = 1428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 527 SVSSDSG 533
>XP_005271570
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  NKSVSDDSG 9
          ++SVS DSG
Sbjct: 77 DRSVSVDSG 85
>XP_005271569
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  NKSVSDDSG 9
          ++SVS DSG
Sbjct: 77 DRSVSVDSG 85
>XP_006718878
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NKSVSDDSG 9
           ++SVS DSG
Sbjct: 114 DRSVSVDSG 122
>XP_005271568
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NKSVSDDSG 9
           ++SVS DSG
Sbjct: 114 DRSVSVDSG 122
>XP_005246882
          Length = 1518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 111 SVSSDSG 117
>XP_006712784
          Length = 1784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 377 SVSSDSG 383
>NP_056134
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVSDDSG 9
           SVS DSG
Sbjct: 518 SVSSDSG 524
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.283    0.109    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 566,084
Number of extensions: 933
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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