Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           19     665
NP_036462                                                              19     665
NP_001243397                                                           19     665
XP_005269721                                                           19     665
NP_006763                                                              19     869
NP_004512                                                              17    2528
NP_004230                                                              17    2528
XP_005268271                                                           17    2528
XP_005268270                                                           17    2528
XP_006720384                                                           17    2528
NP_940966                                                              17    4312
NP_001242941                                                           17    4312
NP_848599                                                              17    4312
NP_005955                                                              17    4312
NP_001243024                                                           17    4312
XP_005256710                                                           17    4312
XP_005256709                                                           17    4312
XP_005256708                                                           17    4312
XP_006713081                                                           17    4312
NP_115523                                                              16    5631
NP_001035862                                                           16    5631
NP_001265322                                                           16    5631
XP_006719692                                                           16    5631
XP_006719691                                                           16    5631
XP_005269230                                                           16    5631
XP_005269231                                                           16    5631
XP_005269229                                                           16    5631
NP_000126                                                              16    7355
NP_001278017                                                           16    7355
NP_114157                                                              16    7355
NP_001092301                                                           16    7355
NP_849154                                                              16    7355
NP_078891                                                              16    7355
NP_001018122                                                           16    7355
NP_001171526                                                           16    7355
NP_001171527                                                           16    7355
NP_001273096                                                           16    7355
NP_001139373                                                           16    7355
NP_060297                                                              16    7355
NP_001257405                                                           16    7355
NP_001193856                                                           16    7355
NP_006236                                                              16    7355
NP_851308                                                              16    7355
NP_851307                                                              16    7355
XP_006723474                                                           16    7355
XP_005259362                                                           16    7355
XP_005256351                                                           16    7355
XP_006721230                                                           16    7355
XP_005250740                                                           16    7355
XP_006715067                                                           16    7355
XP_005248654                                                           16    7355
XP_005248653                                                           16    7355
NP_004320                                                              15    9605
NP_057712                                                              15    9605
NP_567823                                                              15    9605
NP_001257711                                                           15    9605
NP_003192                                                              15    9605
NP_001275913                                                           15    9605
NP_060585                                                              15    9605
XP_005252516                                                           15    9605
XP_005252514                                                           15    9605
XP_005252511                                                           15    9605
XP_005263162                                                           15    9605
XP_005263159                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NKLLRRTIE 9
           NKLLRR IE
Sbjct: 108 NKLLRRAIE 116
>NP_036462
          Length = 2073

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NKLLRRTIE 9
           NKLLRR IE
Sbjct: 108 NKLLRRAIE 116
>NP_001243397
          Length = 1890

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NKLLRRTIE 9
           NKLLRR IE
Sbjct: 108 NKLLRRAIE 116
>XP_005269721
          Length = 2073

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NKLLRRTIE 9
           NKLLRR IE
Sbjct: 108 NKLLRRAIE 116
>NP_006763
          Length = 1343

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  NKLLRRTI 8
          NKLLRRT+
Sbjct: 79 NKLLRRTV 86
>NP_004512
          Length = 963

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NKLLRRTIE 9
           NK+LR TI+
Sbjct: 351 NKILRNTIQ 359
>NP_004230
          Length = 1979

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKLLRRTIE 9
           N++LR+TIE
Sbjct: 841 NEILRQTIE 849
>XP_005268271
          Length = 1537

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKLLRRTIE 9
           N++LR+TIE
Sbjct: 399 NEILRQTIE 407
>XP_005268270
          Length = 1950

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKLLRRTIE 9
           N++LR+TIE
Sbjct: 812 NEILRQTIE 820
>XP_006720384
          Length = 1978

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   NKLLRRTIE 9
           N++LR+TIE
Sbjct: 840 NEILRQTIE 848
>NP_940966
          Length = 457

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLRRTIE 9
           LLRRT+E
Sbjct: 303 LLRRTVE 309
>NP_001242941
          Length = 2007

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    NKLLRRT 7
            NKL+RRT
Sbjct: 1872 NKLVRRT 1878
>NP_848599
          Length = 3092

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLRRTIE 9
           LLRRT+E
Sbjct: 303 LLRRTVE 309
>NP_005955
          Length = 1976

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    NKLLRRT 7
            NKL+RRT
Sbjct: 1841 NKLVRRT 1847
>NP_001243024
          Length = 1985

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    NKLLRRT 7
            NKL+RRT
Sbjct: 1850 NKLVRRT 1856
>XP_005256710
          Length = 1986

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    NKLLRRT 7
            NKL+RRT
Sbjct: 1851 NKLVRRT 1857
>XP_005256709
          Length = 1997

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    NKLLRRT 7
            NKL+RRT
Sbjct: 1862 NKLVRRT 1868
>XP_005256708
          Length = 2007

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    NKLLRRT 7
            NKL+RRT
Sbjct: 1872 NKLVRRT 1878
>XP_006713081
          Length = 3964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLRRTIE 9
           LLRRT+E
Sbjct: 303 LLRRTVE 309
>NP_115523
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>NP_001035862
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>NP_001265322
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>XP_006719692
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>XP_006719691
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>XP_005269230
          Length = 743

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>XP_005269231
          Length = 743

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>XP_005269229
          Length = 743

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLLRRTI 8
           KLLRRT+
Sbjct: 96  KLLRRTL 102
>NP_000126
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKLLRRTIE 9
           N  LRRT+E
Sbjct: 250 NSDLRRTVE 258
>NP_001278017
          Length = 2912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LLRRTIE 9
            +LRRT+E
Sbjct: 2509 ILRRTVE 2515
>NP_114157
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LLRRTIE 9
            +LRRT+E
Sbjct: 2470 ILRRTVE 2476
>NP_001092301
          Length = 146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NKLLRR 6
           NKLLRR
Sbjct: 119 NKLLRR 124
>NP_849154
          Length = 146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NKLLRR 6
           NKLLRR
Sbjct: 119 NKLLRR 124
>NP_078891
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NKLLRRT 7
           +KLLRRT
Sbjct: 315 HKLLRRT 321
>NP_001018122
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKLLRRTIE 9
           N  LRRT+E
Sbjct: 250 NSDLRRTVE 258
>NP_001171526
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NKLLRRT 7
           +KLLRRT
Sbjct: 315 HKLLRRT 321
>NP_001171527
          Length = 812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NKLLRRT 7
           +KLLRRT
Sbjct: 315 HKLLRRT 321
>NP_001273096
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKLLRRTIE 9
           N  LRRT+E
Sbjct: 250 NSDLRRTVE 258
>NP_001139373
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NKLLRR 6
           NKLLRR
Sbjct: 250 NKLLRR 255
>NP_060297
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   NKLLRR 6
           NKLLRR
Sbjct: 248 NKLLRR 253
>NP_001257405
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KLLRRTIE 9
           +LL+RT+E
Sbjct: 394 QLLKRTVE 401
>NP_001193856
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKLLRRTI 8
            N+LLRR I
Sbjct: 3807 NQLLRRVI 3814
>NP_006236
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KLLRRTIE 9
           +LL+RT+E
Sbjct: 545 QLLKRTVE 552
>NP_851308
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KLLRRTIE 9
           +LL+RT+E
Sbjct: 439 QLLKRTVE 446
>NP_851307
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KLLRRTIE 9
           +LL+RT+E
Sbjct: 513 QLLKRTVE 520
>XP_006723474
          Length = 2737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LLRRTIE 9
            +LRRT+E
Sbjct: 2334 ILRRTVE 2340
>XP_005259362
          Length = 2855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LLRRTIE 9
            +LRRT+E
Sbjct: 2452 ILRRTVE 2458
>XP_005256351
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKLLRRTIE 9
           N  LRRT+E
Sbjct: 250 NSDLRRTVE 258
>XP_006721230
          Length = 1412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NKLLRRTIE 9
           N  LRRT+E
Sbjct: 250 NSDLRRTVE 258
>XP_005250740
          Length = 1053

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    KLLRRTI 8
            +LLRRTI
Sbjct: 1043 RLLRRTI 1049
>XP_006715067
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NKLLRRTI 8
            N+LLRR I
Sbjct: 3807 NQLLRRVI 3814
>XP_005248654
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  NKLLRRT 7
          +KLLRRT
Sbjct: 68 HKLLRRT 74
>XP_005248653
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NKLLRRT 7
           +KLLRRT
Sbjct: 356 HKLLRRT 362
>NP_004320
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LRRTIE 9
           LRRTIE
Sbjct: 118 LRRTIE 123
>NP_057712
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NKLLRRT 7
          NK+LRR+
Sbjct: 56 NKMLRRS 62
>NP_567823
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NKLLRRT 7
          NK+LRR+
Sbjct: 56 NKMLRRS 62
>NP_001257711
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLRRTIE 9
           LLRRTI+
Sbjct: 198 LLRRTIK 204
>NP_003192
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLRRTIE 9
           LLRRTI+
Sbjct: 230 LLRRTIK 236
>NP_001275913
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NKLLRRTI 8
          +KLLR+T+
Sbjct: 33 DKLLRKTL 40
>NP_060585
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NKLLRRTI 8
           +KLLR+T+
Sbjct: 130 DKLLRKTL 137
>XP_005252516
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NKLLRRT 7
          NK+LRR+
Sbjct: 62 NKMLRRS 68
>XP_005252514
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NKLLRRT 7
          NK+LRR+
Sbjct: 11 NKMLRRS 17
>XP_005252511
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NKLLRRT 7
          NK+LRR+
Sbjct: 62 NKMLRRS 68
>XP_005263162
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NKLLRRTI 8
          +KLLR+T+
Sbjct: 33 DKLLRKTL 40
>XP_005263159
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NKLLRRTI 8
           +KLLR+T+
Sbjct: 105 DKLLRKTL 112
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.140    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 387,512
Number of extensions: 493
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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