Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           21     229
NP_004561                                                              21     229
XP_005253450                                                           21     229
XP_006719151                                                           21     229
NP_001005739                                                           17    3301
NP_057600                                                              17    3301
NP_061833                                                              17    3301
XP_006712092                                                           17    3301
XP_006710801                                                           17    4312
NP_775886                                                              16    5631
NP_065765                                                              16    5631
XP_006726674                                                           16    5631
XP_006721084                                                           16    5631
NP_001006658                                                           16    7355
NP_065830                                                              16    7355
NP_001120674                                                           16    7355
NP_001245142                                                           16    7355
NP_001120675                                                           16    7355
NP_060856                                                              16    7355
NP_001245141                                                           16    7355
NP_006648                                                              16    7355
NP_001258857                                                           16    7355
NP_001258856                                                           16    7355
NP_996848                                                              16    7355
NP_060046                                                              16    7355
XP_006724025                                                           16    7355
XP_006724024                                                           16    7355
XP_006724023                                                           16    7355
XP_006720039                                                           16    7355
XP_005268381                                                           16    7355
XP_005252149                                                           16    7355
XP_005252148                                                           16    7355
XP_006717241                                                           16    7355
XP_006717240                                                           16    7355
XP_005252147                                                           16    7355
XP_005252146                                                           16    7355
XP_006717239                                                           16    7355
NP_919415                                                              16    7355
NP_003565                                                              16    7355
NP_001804                                                              15    9605
NP_001367                                                              15    9605
NP_001990                                                              15    9605
NP_005484                                                              15    9605
NP_079500                                                              15    9605
NP_001273663                                                           15    9605
NP_001171864                                                           15    9605
NP_053586                                                              15    9605
NP_053584                                                              15    9605
NP_004874                                                              15    9605
NP_053585                                                              15    9605
NP_001091873                                                           15    9605
NP_001091872                                                           15    9605
NP_001263295                                                           15    9605
NP_065778                                                              15    9605
NP_378669                                                              15    9605
NP_001263297                                                           15    9605
NP_001263296                                                           15    9605
NP_005550                                                              15    9605
NP_037458                                                              15    9605
NP_001263271                                                           15    9605
XP_005261180                                                           15    9605
XP_005261178                                                           15    9605
XP_005260254                                                           15    9605
XP_005260255                                                           15    9605
XP_005260252                                                           15    9605
XP_006723763                                                           15    9605
XP_005260253                                                           15    9605
XP_006722508                                                           15    9605
XP_006715008                                                           15    9605
XP_005268590                                                           15    9605
XP_006714871                                                           15    9605
NP_056229                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  NKAHQISLN 9
          N+AHQISLN
Sbjct: 79 NEAHQISLN 87
>NP_004561
          Length = 1445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  NKAHQISLN 9
          N+AHQISLN
Sbjct: 79 NEAHQISLN 87
>XP_005253450
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  NKAHQISLN 9
          N+AHQISLN
Sbjct: 79 NEAHQISLN 87
>XP_006719151
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  NKAHQISLN 9
          N+AHQISLN
Sbjct: 79 NEAHQISLN 87
>NP_001005739
          Length = 965

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NKAHQISL 8
           N AHQISL
Sbjct: 207 NIAHQISL 214
>NP_057600
          Length = 977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NKAHQISL 8
           N AHQISL
Sbjct: 219 NIAHQISL 226
>NP_061833
          Length = 295

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NKAHQISLN 9
           NKAH ++L+
Sbjct: 214 NKAHMVTLD 222
>XP_006712092
          Length = 941

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   NKAHQISL 8
           N AHQISL
Sbjct: 219 NIAHQISL 226
>XP_006710801
          Length = 647

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NKAHQISL 8
           NKAHQ S+
Sbjct: 349 NKAHQSSV 356
>NP_775886
          Length = 1184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    KAHQISLN 9
            K H ISLN
Sbjct: 1083 KVHTISLN 1090
>NP_065765
          Length = 529

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HQISLN 9
           HQ+SLN
Sbjct: 167 HQVSLN 172
>XP_006726674
          Length = 1205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    KAHQISLN 9
            K H ISLN
Sbjct: 1104 KVHTISLN 1111
>XP_006721084
          Length = 1205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    KAHQISLN 9
            K H ISLN
Sbjct: 1104 KVHTISLN 1111
>NP_001006658
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KAHQISLN 9
           +A+Q+SLN
Sbjct: 545 RAYQLSLN 552
>NP_065830
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KAHQISLN 9
           +A+Q+SLN
Sbjct: 534 RAYQLSLN 541
>NP_001120674
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K HQ+SL+
Sbjct: 334 KTHQLSLD 341
>NP_001245142
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K HQ+SL+
Sbjct: 332 KTHQLSLD 339
>NP_001120675
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K HQ+SL+
Sbjct: 334 KTHQLSLD 341
>NP_060856
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K HQ+SL+
Sbjct: 334 KTHQLSLD 341
>NP_001245141
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K HQ+SL+
Sbjct: 388 KTHQLSLD 395
>NP_006648
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KAHQISLN 9
           +AH+I+LN
Sbjct: 195 QAHRIALN 202
>NP_001258857
          Length = 1304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>NP_001258856
          Length = 1335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>NP_996848
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KAHQISLN 9
           +AH+I+LN
Sbjct: 195 QAHRIALN 202
>NP_060046
          Length = 1401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>XP_006724025
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KAHQISLN 9
           +AH+I+LN
Sbjct: 195 QAHRIALN 202
>XP_006724024
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KAHQISLN 9
           +AH+I+LN
Sbjct: 195 QAHRIALN 202
>XP_006724023
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KAHQISLN 9
           +AH+I+LN
Sbjct: 195 QAHRIALN 202
>XP_006720039
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K HQ+SL+
Sbjct: 167 KTHQLSLD 174
>XP_005268381
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K HQ+SL+
Sbjct: 332 KTHQLSLD 339
>XP_005252149
          Length = 921

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  NKAHQISL 8
          NK H +SL
Sbjct: 37 NKGHAVSL 44
>XP_005252148
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 159 NKGHAVSL 166
>XP_006717241
          Length = 1136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>XP_006717240
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>XP_005252147
          Length = 1329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>XP_005252146
          Length = 1342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>XP_006717239
          Length = 1401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           NK H +SL
Sbjct: 517 NKGHAVSL 524
>NP_919415
          Length = 249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KAHQISLN 9
           K H +SLN
Sbjct: 161 KPHSVSLN 168
>NP_003565
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KAHQISLN 9
           K H +SLN
Sbjct: 206 KPHSVSLN 213
>NP_001804
          Length = 2701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K H++S+N
Sbjct: 449 KTHKLSIN 456
>NP_001367
          Length = 4646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NKAHQ 5
           NKAHQ
Sbjct: 766 NKAHQ 770
>NP_001990
          Length = 2912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NKAHQISLN 9
            N  HQ S+N
Sbjct: 1414 NGTHQCSIN 1422
>NP_005484
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NKAHQ 5
           NKAHQ
Sbjct: 520 NKAHQ 524
>NP_079500
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AHQISLN 9
           AH +SLN
Sbjct: 403 AHSLSLN 409
>NP_001273663
          Length = 2580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   KAHQISLN 9
           K H++S+N
Sbjct: 449 KTHKLSIN 456
>NP_001171864
          Length = 784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           N AH +SL
Sbjct: 558 NSAHAVSL 565
>NP_053586
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           N AH +SL
Sbjct: 626 NSAHAVSL 633
>NP_053584
          Length = 844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           N AH +SL
Sbjct: 618 NSAHAVSL 625
>NP_004874
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           N AH +SL
Sbjct: 624 NSAHAVSL 631
>NP_053585
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           N AH +SL
Sbjct: 632 NSAHAVSL 639
>NP_001091873
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NKAHQISL 8
          N AH ISL
Sbjct: 9  NPAHAISL 16
>NP_001091872
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NKAHQISL 8
          N AH ISL
Sbjct: 9  NPAHAISL 16
>NP_001263295
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  KAHQISLN 9
          K H ISLN
Sbjct: 44 KMHGISLN 51
>NP_065778
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NKAHQISL 8
          N AH ISL
Sbjct: 9  NPAHAISL 16
>NP_378669
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  NKAHQISLN 9
          NK H+++ N
Sbjct: 12 NKGHKVTKN 20
>NP_001263297
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  KAHQISLN 9
          K H ISLN
Sbjct: 44 KMHGISLN 51
>NP_001263296
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  KAHQISLN 9
          K H ISLN
Sbjct: 44 KMHGISLN 51
>NP_005550
          Length = 3075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   HQISLN 9
           HQ+S+N
Sbjct: 550 HQVSIN 555
>NP_037458
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AHQISLN 9
           AHQ+SL+
Sbjct: 547 AHQLSLD 553
>NP_001263271
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AHQISLN 9
           AHQ+SL+
Sbjct: 499 AHQLSLD 505
>XP_005261180
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NKAHQISL 8
          N AH ISL
Sbjct: 9  NPAHAISL 16
>XP_005261178
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  NKAHQISL 8
          N AH ISL
Sbjct: 9  NPAHAISL 16
>XP_005260254
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AHQISLN 9
           AH +SLN
Sbjct: 403 AHSLSLN 409
>XP_005260255
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AHQISLN 9
           AH +SLN
Sbjct: 403 AHSLSLN 409
>XP_005260252
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AHQISLN 9
           AH +SLN
Sbjct: 403 AHSLSLN 409
>XP_006723763
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AHQISLN 9
           AH +SLN
Sbjct: 403 AHSLSLN 409
>XP_005260253
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AHQISLN 9
           AH +SLN
Sbjct: 403 AHSLSLN 409
>XP_006722508
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AHQISLN 9
           AHQ+SL+
Sbjct: 547 AHQLSLD 553
>XP_006715008
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NKAHQ 5
           NKAHQ
Sbjct: 291 NKAHQ 295
>XP_005268590
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           N AH +SL
Sbjct: 233 NSAHAVSL 240
>XP_006714871
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NKAHQISL 8
           N AH +SL
Sbjct: 421 NSAHAVSL 428
>NP_056229
          Length = 105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  NKAHQISLN 9
          NK H+++ N
Sbjct: 12 NKGHKVTKN 20
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.117    0.310 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 521,165
Number of extensions: 1008
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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