Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results 
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done




                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           18    1135
NP_004561                                                              18    1135
XP_005253450                                                           18    1135
XP_006719151                                                           18    1135
NP_001755                                                              17    3301
NP_001005198                                                           17    4312
NP_001002905                                                           17    4312
NP_849155                                                              16    5631
NP_067645                                                              16    5631
XP_006714150                                                           16    5631
XP_005262815                                                           16    5631
XP_005262814                                                           16    5631
XP_006714149                                                           16    5631
XP_006714148                                                           16    5631
XP_006714147                                                           16    5631
NP_056144                                                              16    7355
XP_005259895                                                           16    7355
XP_005259894                                                           16    7355
NP_001005465                                                           16    7355
NP_001003794                                                           15    9605
NP_009214                                                              15    9605
NP_001121685                                                           15    9605
NP_001121684                                                           15    9605
XP_005274043                                                           15    9605
XP_006718611                                                           15    9605
XP_005248296                                                           15    9605
XP_005248295                                                           15    9605
XP_005247150                                                           15    9605
XP_006712405                                                           15    9605
XP_006712404                                                           15    9605
XP_005246413                                                           15    9605
XP_005246412                                                           15    9605
NP_689741                                                              15    9605
NP_001034841                                                           15    9605
NP_009208                                                              15    9605
YP_003024035                                                           15    9605



>NP_001275701
          Length = 1486

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           NIV PSLML
Sbjct: 199 NIVEPSLML 207





>NP_004561
          Length = 1445

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           NIV PSLML
Sbjct: 199 NIVEPSLML 207





>XP_005253450
          Length = 1486

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           NIV PSLML
Sbjct: 199 NIVEPSLML 207





>XP_006719151
          Length = 1486

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           NIV PSLML
Sbjct: 199 NIVEPSLML 207





>NP_001755
          Length = 333

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           I+VPSL+L
Sbjct: 308 IIVPSLLL 315





>NP_001005198
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           NI+VPSL +
Sbjct: 241 NILVPSLTI 249





>NP_001002905
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           NI+VPSL +
Sbjct: 206 NILVPSLTI 214





>NP_849155
          Length = 537

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           +VVPS++L
Sbjct: 248 VVVPSMLL 255





>NP_067645
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIVVPSLM 8
           N+VVPS++
Sbjct: 514 NVVVPSVI 521





>XP_006714150
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           +VVPS++L
Sbjct: 191 VVVPSMLL 198





>XP_005262815
          Length = 474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           +VVPS++L
Sbjct: 248 VVVPSMLL 255





>XP_005262814
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           +VVPS++L
Sbjct: 191 VVVPSMLL 198





>XP_006714149
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           +VVPS++L
Sbjct: 191 VVVPSMLL 198





>XP_006714148
          Length = 537

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           +VVPS++L
Sbjct: 248 VVVPSMLL 255





>XP_006714147
          Length = 537

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IVVPSLML 9
           +VVPS++L
Sbjct: 248 VVVPSMLL 255





>NP_056144
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+VVP++ L
Sbjct: 520 NMVVPAMQL 528





>XP_005259895
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+VVP++ L
Sbjct: 531 NMVVPAMQL 539





>XP_005259894
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+VVP++ L
Sbjct: 558 NMVVPAMQL 566





>NP_001005465
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NIVVPSLML 9
          +I+VP LM+
Sbjct: 76 SIIVPRLMM 84





>NP_001003794
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+P+L L
Sbjct: 168 NLVLPNLSL 176





>NP_009214
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+P+L L
Sbjct: 178 NLVLPNLSL 186





>NP_001121685
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+PS +L
Sbjct: 449 NLVLPSAVL 457





>NP_001121684
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+PS +L
Sbjct: 449 NLVLPSAVL 457





>XP_005274043
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VVPSLML 9
          ++PSLML
Sbjct: 24 ILPSLML 30





>XP_006718611
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VVPSLML 9
          ++PSLML
Sbjct: 24 ILPSLML 30





>XP_005248296
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIVVPSL 7
           +IVVPSL
Sbjct: 617 DIVVPSL 623





>XP_005248295
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIVVPSL 7
           +IVVPSL
Sbjct: 732 DIVVPSL 738





>XP_005247150
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+P+L L
Sbjct: 142 NLVLPNLSL 150





>XP_006712405
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+PS +L
Sbjct: 211 NLVLPSAVL 219





>XP_006712404
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+PS +L
Sbjct: 280 NLVLPSAVL 288





>XP_005246413
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+PS +L
Sbjct: 357 NLVLPSAVL 365





>XP_005246412
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+PS +L
Sbjct: 402 NLVLPSAVL 410





>NP_689741
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIVVPSLML 9
           N+V+PS +L
Sbjct: 449 NLVLPSAVL 457





>NP_001034841
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VVPSLML 9
          ++PSLML
Sbjct: 24 ILPSLML 30





>NP_009208
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIVVPSL 7
           +IVVPSL
Sbjct: 732 DIVVPSL 738





>YP_003024035
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  IVVPSLML 9
          ++VP++ML
Sbjct: 4  LIVPTIML 11





  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.144    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 610,174
Number of extensions: 422
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package