Blast-Search of mutated query peptide against human proteome |
BLASTP 2.2.15 [Oct-15-2006] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= User_input (9 letters) Database: HUMAN_PROTEOME_FASTA 71,491 sequences; 45,948,801 total letters Searching..................................................doneScore E Sequences producing significant alignments: (bits) Value NP_001277144 20 509 NP_001277143 20 509 NP_001077383 20 509 NP_001320 20 509 NP_073713 20 509 XP_005269629 20 509 XP_005269628 20 509 XP_005269627 20 509 XP_005269626 20 509 XP_006717706 20 509 XP_005269625 20 509 XP_005269624 20 509 XP_006717705 20 509 XP_005269622 20 509 XP_005269621 20 509 XP_006717704 20 509 XP_005269619 20 509 XP_005269618 20 509 NP_001319 19 665 NP_001012632 19 665 XP_005272320 19 665 XP_005272319 19 665 XP_005272318 19 665 NP_004999 17 2528 NP_001003796 17 2528 XP_006724321 17 2528 XP_005261677 17 2528 NP_997244 17 4312 NP_570925 17 4312 NP_570924 17 4312 NP_570923 17 4312 NP_569707 17 4312 NP_002831 17 4312 XP_006724744 17 4312 XP_006724743 17 4312 XP_006722884 17 4312 XP_005259667 17 4312 XP_005259666 17 4312 XP_005259664 17 4312 XP_005259663 17 4312 XP_005259658 17 4312 XP_005259657 17 4312 XP_006716902 17 4312 XP_006716901 17 4312 XP_006716897 17 4312 XP_006716890 17 4312 XP_006716889 17 4312 XP_006710864 17 4312 XP_005271139 17 4312 XP_006710863 17 4312 XP_006710862 17 4312 XP_006710861 17 4312 XP_005271138 17 4312 XP_006710860 17 4312 XP_006710859 17 4312 XP_005271137 17 4312 XP_006710858 17 4312 XP_005271136 17 4312 NP_001033056 16 7355 NP_000023 16 7355 NP_001258875 16 7355 NP_001033057 16 7355 NP_008832 16 7355 NP_003053 16 7355 NP_001162597 16 7355 NP_653216 16 7355 XP_005262052 16 7355 XP_006720604 16 7355 XP_005254461 16 7355 XP_006720603 16 7355 XP_006720602 16 7355 NP_001182465 15 9605 NP_057494 15 9605 NP_001264198 15 9605 NP_006853 15 9605 NP_001077434 15 9605 NP_001077433 15 9605 NP_001077432 15 9605 NP_079040 15 9605 XP_005273954 15 9605 XP_005244911 15 9605 XP_005244910 15 9605>NP_001277144 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>NP_001277143 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>NP_001077383 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>NP_001320 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>NP_073713 Length = 985 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 798 IKQMRQGA 805>XP_005269629 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269628 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269627 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269626 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_006717706 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269625 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269624 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_006717705 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269622 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269621 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_006717704 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269619 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>XP_005269618 Length = 445 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IKQMRQGA Sbjct: 258 IKQMRQGA 265>NP_001319 Length = 440 Score = 19.2 bits (38), Expect = 665 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 +KQMRQGA Sbjct: 252 VKQMRQGA 259>NP_001012632 Length = 429 Score = 19.2 bits (38), Expect = 665 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 +KQMRQGA Sbjct: 241 VKQMRQGA 248>XP_005272320 Length = 430 Score = 19.2 bits (38), Expect = 665 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 +KQMRQGA Sbjct: 241 VKQMRQGA 248>XP_005272319 Length = 430 Score = 19.2 bits (38), Expect = 665 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 +KQMRQGA Sbjct: 241 VKQMRQGA 248>XP_005272318 Length = 441 Score = 19.2 bits (38), Expect = 665 Identities = 7/8 (87%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 +KQMRQGA Sbjct: 252 VKQMRQGA 259>NP_004999 Length = 128 Score = 17.3 bits (33), Expect = 2528 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 NIKQMRQGA 9 N KQ+R+GA Sbjct: 31 NYKQLRKGA 39>NP_001003796 Length = 128 Score = 17.3 bits (33), Expect = 2528 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 NIKQMRQGA 9 N KQ+R+GA Sbjct: 31 NYKQLRKGA 39>XP_006724321 Length = 272 Score = 17.3 bits (33), Expect = 2528 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 NIKQMRQGA 9 N KQ+R+GA Sbjct: 175 NYKQLRKGA 183>XP_005261677 Length = 294 Score = 17.3 bits (33), Expect = 2528 Identities = 6/9 (66%), Positives = 8/9 (88%) Query: 1 NIKQMRQGA 9 N KQ+R+GA Sbjct: 197 NYKQLRKGA 205>NP_997244 Length = 3169 Score = 16.5 bits (31), Expect = 4312 Identities = 5/8 (62%), Positives = 7/8 (87%) Query: 1 NIKQMRQG 8 N+K +RQG Sbjct: 1137 NLKDLRQG 1144>NP_570925 Length = 1505 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>NP_570924 Length = 1910 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>NP_570923 Length = 1501 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>NP_569707 Length = 1898 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>NP_002831 Length = 1907 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006724744 Length = 1851 Score = 16.5 bits (31), Expect = 4312 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 KQMRQG 8 KQMRQG Sbjct: 1704 KQMRQG 1709>XP_006724743 Length = 1924 Score = 16.5 bits (31), Expect = 4312 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 KQMRQG 8 KQMRQG Sbjct: 1704 KQMRQG 1709>XP_006722884 Length = 1490 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005259667 Length = 1497 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005259666 Length = 1501 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005259664 Length = 1906 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005259663 Length = 1910 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005259658 Length = 1935 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005259657 Length = 1935 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006716902 Length = 1491 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 175 IKQLRSGA 182>XP_006716901 Length = 1495 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 175 IKQLRSGA 182>XP_006716897 Length = 1505 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 175 IKQLRSGA 182>XP_006716890 Length = 1893 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 175 IKQLRSGA 182>XP_006716889 Length = 1899 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 175 IKQLRSGA 182>XP_006710864 Length = 1729 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005271139 Length = 1796 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006710863 Length = 1811 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006710862 Length = 1820 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006710861 Length = 1902 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005271138 Length = 1909 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006710860 Length = 1911 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006710859 Length = 1913 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005271137 Length = 1918 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_006710858 Length = 1922 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>XP_005271136 Length = 1922 Score = 16.5 bits (31), Expect = 4312 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 IKQMRQGA 9 IKQ+R GA Sbjct: 184 IKQLRSGA 191>NP_001033056 Length = 550 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 NIKQMRQ 7 N+K MRQ Sbjct: 416 NVKHMRQ 422>NP_000023 Length = 587 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 NIKQMRQ 7 N+K MRQ Sbjct: 453 NVKHMRQ 459>NP_001258875 Length = 1530 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IK++R+GA Sbjct: 569 IKEVREGA 576>NP_001033057 Length = 574 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 NIKQMRQ 7 N+K MRQ Sbjct: 440 NVKHMRQ 446>NP_008832 Length = 2548 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK++RQG Sbjct: 2106 IKELRQG 2112>NP_003053 Length = 1523 Score = 15.8 bits (29), Expect = 7355 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 2 IKQMRQGA 9 IK++R+GA Sbjct: 569 IKEVREGA 576>NP_001162597 Length = 278 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 NIKQMRQGA 9 N+ Q+RQG+ Sbjct: 30 NLLQVRQGS 38>NP_653216 Length = 282 Score = 15.8 bits (29), Expect = 7355 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 NIKQMRQGA 9 N+ Q+RQG+ Sbjct: 30 NLLQVRQGS 38>XP_005262052 Length = 611 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 NIKQMRQ 7 N+K MRQ Sbjct: 477 NVKHMRQ 483>XP_006720604 Length = 1677 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK++RQG Sbjct: 1235 IKELRQG 1241>XP_005254461 Length = 2600 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK++RQG Sbjct: 2158 IKELRQG 2164>XP_006720603 Length = 2619 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK++RQG Sbjct: 2177 IKELRQG 2183>XP_006720602 Length = 2619 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK++RQG Sbjct: 2177 IKELRQG 2183>NP_001182465 Length = 171 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK+MR+G Sbjct: 49 IKKMREG 55>NP_057494 Length = 219 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK+MR+G Sbjct: 49 IKKMREG 55>NP_001264198 Length = 2925 Score = 15.4 bits (28), Expect = 9605 Identities = 5/8 (62%), Positives = 6/8 (75%) Query: 1 NIKQMRQG 8 N+K MR G Sbjct: 48 NVKGMRNG 55>NP_006853 Length = 561 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 1 NIKQMRQ 7 NIKQ+R+ Sbjct: 74 NIKQLRK 80>NP_001077434 Length = 561 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 1 NIKQMRQ 7 NIKQ+R+ Sbjct: 74 NIKQLRK 80>NP_001077433 Length = 516 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 1 NIKQMRQ 7 NIKQ+R+ Sbjct: 74 NIKQLRK 80>NP_001077432 Length = 561 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 1 NIKQMRQ 7 NIKQ+R+ Sbjct: 74 NIKQLRK 80>NP_079040 Length = 1116 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 1 NIKQMRQ 7 NIK+M+Q Sbjct: 992 NIKRMKQ 998>XP_005273954 Length = 1676 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 IKQMRQG 8 IK+MR+G Sbjct: 1670 IKEMRRG 1676>XP_005244911 Length = 561 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 1 NIKQMRQ 7 NIKQ+R+ Sbjct: 74 NIKQLRK 80>XP_005244910 Length = 561 Score = 15.4 bits (28), Expect = 9605 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 1 NIKQMRQ 7 NIKQ+R+ Sbjct: 74 NIKQLRK 80Database: HUMAN_PROTEOME_FASTA Posted date: May 26, 2014 10:46 AM Number of letters in database: 45,948,801 Number of sequences in database: 71,491 Lambda K H 0.318 0.126 0.331 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 71491 Number of Hits to DB: 423,047 Number of extensions: 651 Number of successful extensions: 82 Number of sequences better than 10000.0: 82 Number of HSP's gapped: 82 Number of HSP's successfully gapped: 82 Length of query: 9 Length of database: 45,948,801 Length adjustment: 0 Effective length of query: 9 Effective length of database: 45,948,801 Effective search space: 413539209 Effective search space used: 413539209 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 28 (15.8 bits) S2: 28 (15.4 bits)
CANCERTOPE | Raghava's Group | IMTECH | CSIR | CRDD | GPSR Package |