Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     299
NP_001161337                                                           18    1935
NP_060085                                                              18    1935
XP_005269987                                                           18    1935
XP_005269986                                                           18    1935
NP_001131146                                                           17    4312
NP_001093164                                                           17    4312
XP_006726843                                                           17    4312
XP_006726842                                                           17    4312
XP_006726841                                                           17    4312
XP_005259508                                                           17    4312
XP_006723586                                                           17    4312
XP_006723585                                                           17    4312
XP_006723084                                                           17    4312
XP_006723083                                                           17    4312
XP_006723082                                                           17    4312
XP_005258584                                                           17    4312
XP_006710113                                                           17    4312
XP_003960942                                                           17    4312
XP_006710112                                                           17    4312
XP_005275906                                                           17    4312
NP_000060                                                              16    5631
NP_079040                                                              16    5631
XP_005245535                                                           16    5631
NP_065840                                                              16    5631
NP_001128522                                                           16    5631
NP_006260                                                              16    7355
NP_003476                                                              16    7355
NP_001171147                                                           16    7355
NP_002546                                                              16    7355
NP_899056                                                              16    7355
NP_005286                                                              16    7355
NP_001004470                                                           16    7355
XP_006726770                                                           16    7355
XP_006726769                                                           16    7355
XP_006725191                                                           16    7355
XP_006725190                                                           16    7355
XP_006721680                                                           16    7355
XP_006721679                                                           16    7355
XP_005268169                                                           16    7355
XP_006720326                                                           16    7355
XP_005268168                                                           16    7355
XP_006720325                                                           16    7355
XP_005268167                                                           16    7355
XP_005253010                                                           16    7355
XP_006718306                                                           16    7355
XP_005253009                                                           16    7355
XP_006710082                                                           16    7355
XP_006710081                                                           16    7355
NP_055791                                                              15    9605
NP_004870                                                              15    9605
NP_001277064                                                           15    9605
NP_057461                                                              15    9605
NP_065095                                                              15    9605
NP_004806                                                              15    9605
NP_001184175                                                           15    9605
NP_899662                                                              15    9605
NP_002886                                                              15    9605
NP_008978                                                              15    9605
NP_001184176                                                           15    9605
XP_006723905                                                           15    9605
XP_005269704                                                           15    9605
XP_006715677                                                           15    9605
XP_005267286                                                           15    9605
XP_005267285                                                           15    9605
XP_005248889                                                           15    9605
XP_005248888                                                           15    9605
XP_005248884                                                           15    9605
XP_006715044                                                           15    9605
XP_006715043                                                           15    9605
XP_006715042                                                           15    9605
XP_006711111                                                           15    9605
XP_005246000                                                           15    9605
>NP_000312
          Length = 928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   NIFHMSLL 8
           NIFHMSLL
Sbjct: 480 NIFHMSLL 487
>NP_001161337
          Length = 384

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIFHMSLLV 9
           NIFH+S ++
Sbjct: 304 NIFHVSFII 312
>NP_060085
          Length = 385

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIFHMSLLV 9
           NIFH+S ++
Sbjct: 304 NIFHVSFII 312
>XP_005269987
          Length = 226

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIFHMSLLV 9
           NIFH+S ++
Sbjct: 145 NIFHVSFII 153
>XP_005269986
          Length = 226

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NIFHMSLLV 9
           NIFH+S ++
Sbjct: 145 NIFHVSFII 153
>NP_001131146
          Length = 632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 210 NFFHSSLL 217
>NP_001093164
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 211 NFFHSSLL 218
>XP_006726843
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_006726842
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_006726841
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_005259508
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_006723586
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_006723585
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_006723084
          Length = 562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 211 NFFHSSLL 218
>XP_006723083
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 211 NFFHSSLL 218
>XP_006723082
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 211 NFFHSSLL 218
>XP_005258584
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 211 NFFHSSLL 218
>XP_006710113
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 218 NFFHSSLL 225
>XP_003960942
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_006710112
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>XP_005275906
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N FH SLL
Sbjct: 194 NFFHSSLL 201
>NP_000060
          Length = 1873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IFHMSLLV 9
           +FH++LLV
Sbjct: 196 LFHIALLV 203
>NP_079040
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NIFHMS 6
           N+FHMS
Sbjct: 897 NMFHMS 902
>XP_005245535
          Length = 1854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IFHMSLLV 9
           +FH++LLV
Sbjct: 196 LFHIALLV 203
>NP_065840
          Length = 1163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIFHMSLL 8
           N+FH+S L
Sbjct: 267 NVFHISRL 274
>NP_001128522
          Length = 1179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIFHMSLL 8
           N+FH+S L
Sbjct: 267 NVFHISRL 274
>NP_006260
          Length = 2156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NIFHMSLLV 9
            N  H SLLV
Sbjct: 2035 NFLHTSLLV 2043
>NP_003476
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           N +H SLL+
Sbjct: 266 NAYHFSLLL 274
>NP_001171147
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           N +H SLL+
Sbjct: 266 NAYHFSLLL 274
>NP_002546
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           ++FH  LLV
Sbjct: 327 SVFHFCLLV 335
>NP_899056
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           ++FH  LLV
Sbjct: 327 SVFHFCLLV 335
>NP_005286
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFHMSLLV 9
           +F MSLL+
Sbjct: 311 VFRMSLLI 318
>NP_001004470
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   NIFHM 5
           NIFHM
Sbjct: 167 NIFHM 171
>XP_006726770
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  NIFHMS 6
          N FHMS
Sbjct: 21 NFFHMS 26
>XP_006726769
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  NIFHMS 6
          N FHMS
Sbjct: 21 NFFHMS 26
>XP_006725191
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           ++FH  LLV
Sbjct: 184 SVFHFCLLV 192
>XP_006725190
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           ++FH  LLV
Sbjct: 457 SVFHFCLLV 465
>XP_006721680
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  NIFHMS 6
          N FHMS
Sbjct: 21 NFFHMS 26
>XP_006721679
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  NIFHMS 6
          N FHMS
Sbjct: 21 NFFHMS 26
>XP_005268169
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           N +H SLL+
Sbjct: 276 NAYHFSLLL 284
>XP_006720326
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           N +H SLL+
Sbjct: 276 NAYHFSLLL 284
>XP_005268168
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           N +H SLL+
Sbjct: 276 NAYHFSLLL 284
>XP_006720325
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           N +H SLL+
Sbjct: 276 NAYHFSLLL 284
>XP_005268167
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           N +H SLL+
Sbjct: 276 NAYHFSLLL 284
>XP_005253010
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           ++FH  LLV
Sbjct: 184 SVFHFCLLV 192
>XP_006718306
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           ++FH  LLV
Sbjct: 327 SVFHFCLLV 335
>XP_005253009
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIFHMSLLV 9
           ++FH  LLV
Sbjct: 412 SVFHFCLLV 420
>XP_006710082
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  NIFHMS 6
          N FHMS
Sbjct: 21 NFFHMS 26
>XP_006710081
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  NIFHMS 6
          N FHMS
Sbjct: 21 NFFHMS 26
>NP_055791
          Length = 1871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    NIFHMS 6
            +IFHMS
Sbjct: 1259 SIFHMS 1264
>NP_004870
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIFHMSLL 8
           ++ HMSLL
Sbjct: 204 SLLHMSLL 211
>NP_001277064
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIFHMSLL 8
           ++ HMSLL
Sbjct: 190 SLLHMSLL 197
>NP_057461
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FHMSLLV 9
           FH++LLV
Sbjct: 126 FHITLLV 132
>NP_065095
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   NIFHMSL 7
           N++H+S+
Sbjct: 148 NVYHLSI 154
>NP_004806
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N+FHM  L
Sbjct: 431 NLFHMQHL 438
>NP_001184175
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>NP_899662
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIFHMSLL 8
           +IFH SL+
Sbjct: 495 DIFHRSLM 502
>NP_002886
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIFHMSLL 8
           +IFH SL+
Sbjct: 495 DIFHRSLM 502
>NP_008978
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>NP_001184176
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>XP_006723905
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIFHMSLL 8
           +IFH SL+
Sbjct: 323 DIFHRSLM 330
>XP_005269704
          Length = 1872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    NIFHMS 6
            +IFHMS
Sbjct: 1259 SIFHMS 1264
>XP_006715677
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FHMSLLV 9
           FH++LLV
Sbjct: 126 FHITLLV 132
>XP_005267286
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FHMSLLV 9
           FH++LLV
Sbjct: 104 FHITLLV 110
>XP_005267285
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FHMSLLV 9
           FH++LLV
Sbjct: 126 FHITLLV 132
>XP_005248889
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>XP_005248888
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>XP_005248884
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>XP_006715044
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>XP_006715043
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>XP_006715042
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FHMSLLV 9
          FH+SLL+
Sbjct: 14 FHVSLLL 20
>XP_006711111
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NIFHMSLL 8
           N+FHM  L
Sbjct: 367 NLFHMQHL 374
>XP_005246000
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   NIFHMSL 7
           N++H+S+
Sbjct: 148 NVYHLSI 154
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.149    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 435,192
Number of extensions: 443
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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