Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     390
NP_671714                                                              20     390
XP_006715890                                                           20     390
XP_005250160                                                           20     390
XP_005250159                                                           20     390
XP_006711677                                                           17    4312
NP_078845                                                              17    4312
NP_003944                                                              17    4312
NP_002238                                                              16    5631
NP_001258448                                                           16    5631
NP_001154825                                                           16    5631
NP_001258447                                                           16    5631
NP_001154824                                                           16    5631
NP_001014797                                                           16    5631
NP_006280                                                              16    5631
NP_002431                                                              16    5631
NP_055874                                                              16    5631
XP_006720784                                                           16    5631
XP_006720783                                                           16    5631
XP_006720782                                                           16    5631
XP_006720781                                                           16    5631
XP_005254772                                                           16    5631
XP_005254771                                                           16    5631
XP_006720780                                                           16    5631
XP_005254769                                                           16    5631
XP_005254770                                                           16    5631
XP_005254765                                                           16    5631
XP_005254767                                                           16    5631
XP_006720779                                                           16    5631
XP_005254768                                                           16    5631
XP_005254764                                                           16    5631
XP_005269842                                                           16    5631
XP_005269838                                                           16    5631
XP_005269835                                                           16    5631
XP_005269837                                                           16    5631
XP_006717893                                                           16    5631
XP_005269844                                                           16    5631
XP_005269833                                                           16    5631
XP_006717891                                                           16    5631
XP_006717890                                                           16    5631
XP_005269854                                                           16    5631
XP_005269853                                                           16    5631
XP_005269852                                                           16    5631
XP_006717889                                                           16    5631
XP_005269849                                                           16    5631
XP_005269846                                                           16    5631
XP_006717888                                                           16    5631
XP_006717887                                                           16    5631
XP_006717886                                                           16    5631
XP_006717885                                                           16    5631
XP_006717884                                                           16    5631
XP_005269836                                                           16    5631
XP_006716915                                                           16    5631
XP_005251621                                                           16    5631
XP_005261543                                                           16    7355
XP_005261542                                                           16    7355
NP_777592                                                              16    7355
NP_001034484                                                           15    9605
NP_060647                                                              15    9605
NP_056994                                                              15    9605
NP_000835                                                              15    9605
NP_870989                                                              15    9605
XP_005251556                                                           15    9605
XP_006716863                                                           15    9605
XP_006716862                                                           15    9605
XP_006716861                                                           15    9605
XP_006716860                                                           15    9605
XP_006716859                                                           15    9605
XP_006716858                                                           15    9605
XP_006714086                                                           15    9605
XP_006714085                                                           15    9605
XP_006714084                                                           15    9605
XP_005265152                                                           15    9605
XP_005264407                                                           15    9605
XP_005264406                                                           15    9605
XP_005264405                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IETMQFEK 9
           IETMQFEK
Sbjct: 678 IETMQFEK 685
>NP_671714
          Length = 3899

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IETMQFEK 9
           IETMQFEK
Sbjct: 678 IETMQFEK 685
>XP_006715890
          Length = 3860

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IETMQFEK 9
           IETMQFEK
Sbjct: 678 IETMQFEK 685
>XP_005250160
          Length = 3939

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IETMQFEK 9
           IETMQFEK
Sbjct: 678 IETMQFEK 685
>XP_005250159
          Length = 3952

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IETMQFEK 9
           IETMQFEK
Sbjct: 678 IETMQFEK 685
>XP_006711677
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NIETMQF 7
           NIE MQF
Sbjct: 191 NIENMQF 197
>NP_078845
          Length = 209

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NIETMQF 7
           NIE MQF
Sbjct: 121 NIENMQF 127
>NP_003944
          Length = 269

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NIETMQF 7
           NIE MQF
Sbjct: 121 NIENMQF 127
>NP_002238
          Length = 1178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 891 NIKSMQFD 898
>NP_001258448
          Length = 1208

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 894 NIKSMQFD 901
>NP_001154825
          Length = 1219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 932 NIKSMQFD 939
>NP_001258447
          Length = 1128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 841 NIKSMQFD 848
>NP_001154824
          Length = 1236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 949 NIKSMQFD 956
>NP_001014797
          Length = 1182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 895 NIKSMQFD 902
>NP_006280
          Length = 2541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 14 VKTMQFE 20
>NP_002431
          Length = 936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   NIETMQFE 8
           N+E M FE
Sbjct: 806 NVENMHFE 813
>NP_055874
          Length = 2542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_006720784
          Length = 2502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_006720783
          Length = 2512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_006720782
          Length = 2517

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_006720781
          Length = 2542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254772
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254771
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_006720780
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254769
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254770
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254765
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254767
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_006720779
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254768
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005254764
          Length = 2557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 16 VKTMQFE 22
>XP_005269842
          Length = 1234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 895 NIKSMQFD 902
>XP_005269838
          Length = 1236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 949 NIKSMQFD 956
>XP_005269835
          Length = 1239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 953 NIKSMQFD 960
>XP_005269837
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 956 NIKSMQFD 963
>XP_006717893
          Length = 1233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 920 NIKSMQFD 927
>XP_005269844
          Length = 1230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 891 NIKSMQFD 898
>XP_005269833
          Length = 1257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 891 NIKSMQFD 898
>XP_006717891
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 829 NIKSMQFD 836
>XP_006717890
          Length = 1145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 831 NIKSMQFD 838
>XP_005269854
          Length = 1177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 891 NIKSMQFD 898
>XP_005269853
          Length = 1178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 891 NIKSMQFD 898
>XP_005269852
          Length = 1181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 895 NIKSMQFD 902
>XP_006717889
          Length = 1205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 891 NIKSMQFD 898
>XP_005269849
          Length = 1207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 920 NIKSMQFD 927
>XP_005269846
          Length = 1209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 895 NIKSMQFD 902
>XP_006717888
          Length = 1210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 924 NIKSMQFD 931
>XP_006717887
          Length = 1211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 924 NIKSMQFD 931
>XP_006717886
          Length = 1234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 920 NIKSMQFD 927
>XP_006717885
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 924 NIKSMQFD 931
>XP_006717884
          Length = 1238

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 924 NIKSMQFD 931
>XP_005269836
          Length = 1238

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NIETMQFE 8
           NI++MQF+
Sbjct: 924 NIKSMQFD 931
>XP_006716915
          Length = 2542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 14 VKTMQFE 20
>XP_005251621
          Length = 2542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IETMQFE 8
          ++TMQFE
Sbjct: 14 VKTMQFE 20
>XP_005261543
          Length = 231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIETMQFE 8
           NIE ++FE
Sbjct: 142 NIEVLRFE 149
>XP_005261542
          Length = 264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIETMQFE 8
           NIE ++FE
Sbjct: 175 NIEVLRFE 182
>NP_777592
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NIETMQFE 8
           NIE ++FE
Sbjct: 418 NIEVLRFE 425
>NP_001034484
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 53 ESMRFEK 59
>NP_060647
          Length = 1770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ETMQFEK 9
            ET+ FEK
Sbjct: 1512 ETLMFEK 1518
>NP_056994
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETMQFEK 9
           ET+QF K
Sbjct: 424 ETLQFSK 430
>NP_000835
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NIETMQFEK 9
           NIE MQ+ K
Sbjct: 505 NIEDMQWGK 513
>NP_870989
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NIETMQFEK 9
           NIE MQ+ K
Sbjct: 505 NIEDMQWGK 513
>XP_005251556
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 53 ESMRFEK 59
>XP_006716863
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 20 ESMRFEK 26
>XP_006716862
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 53 ESMRFEK 59
>XP_006716861
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 53 ESMRFEK 59
>XP_006716860
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 53 ESMRFEK 59
>XP_006716859
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 53 ESMRFEK 59
>XP_006716858
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ETMQFEK 9
          E+M+FEK
Sbjct: 53 ESMRFEK 59
>XP_006714086
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ETMQFEK 9
            ET+ FEK
Sbjct: 1432 ETLMFEK 1438
>XP_006714085
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ETMQFEK 9
            ET+ FEK
Sbjct: 1432 ETLMFEK 1438
>XP_006714084
          Length = 1753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ETMQFEK 9
            ET+ FEK
Sbjct: 1512 ETLMFEK 1518
>XP_005265152
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NIETMQFEK 9
           NIE MQ+ K
Sbjct: 505 NIEDMQWGK 513
>XP_005264407
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETMQFEK 9
           ET+QF K
Sbjct: 265 ETLQFSK 271
>XP_005264406
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETMQFEK 9
           ET+QF K
Sbjct: 277 ETLQFSK 283
>XP_005264405
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETMQFEK 9
           ET+QF K
Sbjct: 424 ETLQFSK 430
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.125    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 374,677
Number of extensions: 517
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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