Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              18    1135
NP_653080                                                              18    1135
XP_005267292                                                           18    1135
XP_005267291                                                           18    1135
XP_005267290                                                           18    1135
NP_002190                                                              17    3301
XP_005263043                                                           17    3301
XP_005263041                                                           17    3301
NP_001139182                                                           16    5631
NP_060833                                                              16    5631
NP_001026879                                                           16    5631
XP_005270007                                                           16    5631
XP_005270005                                                           16    5631
XP_005270003                                                           16    5631
NP_001106970                                                           16    7355
NP_878250                                                              16    7355
XP_006720131                                                           16    7355
NP_803173                                                              15    9605
>NP_005091
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NIESSELVT 9
            +IESSELVT
Sbjct: 1129 SIESSELVT 1137
>NP_653080
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NIESSELVT 9
            +IESSELVT
Sbjct: 1031 SIESSELVT 1039
>XP_005267292
          Length = 1677

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NIESSELVT 9
            +IESSELVT
Sbjct: 1024 SIESSELVT 1032
>XP_005267291
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NIESSELVT 9
            +IESSELVT
Sbjct: 1031 SIESSELVT 1039
>XP_005267290
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NIESSELVT 9
            +IESSELVT
Sbjct: 1129 SIESSELVT 1137
>NP_002190
          Length = 349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NIESSELVT 9
           NIE+ E+VT
Sbjct: 186 NIENQEIVT 194
>XP_005263043
          Length = 187

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  NIESSELVT 9
          NIE+ E+VT
Sbjct: 24 NIENQEIVT 32
>XP_005263041
          Length = 347

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NIESSELVT 9
           NIE+ E+VT
Sbjct: 184 NIENQEIVT 192
>NP_001139182
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NIESSELVT 9
          N++S +LVT
Sbjct: 3  NVDSDDLVT 11
>NP_060833
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIESSEL 7
           NIESSE+
Sbjct: 232 NIESSEI 238
>NP_001026879
          Length = 342

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIESSEL 7
           NIESSE+
Sbjct: 232 NIESSEI 238
>XP_005270007
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIESSEL 7
           NIESSE+
Sbjct: 149 NIESSEI 155
>XP_005270005
          Length = 259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIESSEL 7
           NIESSE+
Sbjct: 149 NIESSEI 155
>XP_005270003
          Length = 306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   NIESSEL 7
           NIESSE+
Sbjct: 232 NIESSEI 238
>NP_001106970
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIESSELVT 9
           NI+  EL+T
Sbjct: 693 NIQKGELIT 701
>NP_878250
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIESSELVT 9
           NI+  EL+T
Sbjct: 464 NIQKGELIT 472
>XP_006720131
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NIESSELVT 9
           NI+  EL+T
Sbjct: 694 NIQKGELIT 702
>NP_803173
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NIESSEL 7
           N+ESSE+
Sbjct: 222 NVESSEV 228
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.111    0.243 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 256,953
Number of extensions: 200
Number of successful extensions: 18
Number of sequences better than 10000.0: 18
Number of HSP's gapped: 18
Number of HSP's successfully gapped: 18
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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