Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     509
NP_001120972                                                           20     509
XP_006716052                                                           20     509
XP_006716051                                                           20     509
NP_002323                                                              17    4312
NP_006293                                                              16    5631
NP_001139630                                                           16    5631
NP_115763                                                              16    5631
NP_115597                                                              16    5631
NP_079223                                                              16    5631
XP_006723946                                                           16    5631
XP_005260632                                                           16    5631
XP_005260631                                                           16    5631
XP_005260630                                                           16    5631
XP_006722085                                                           16    5631
XP_006722084                                                           16    5631
XP_005257655                                                           16    5631
XP_006722083                                                           16    5631
XP_005257654                                                           16    5631
XP_005257653                                                           16    5631
XP_005257652                                                           16    5631
XP_006713820                                                           16    5631
XP_005247850                                                           16    5631
XP_005247848                                                           16    5631
XP_006713819                                                           16    5631
XP_005247847                                                           16    5631
XP_006713818                                                           16    5631
XP_006713817                                                           16    5631
XP_006713816                                                           16    5631
XP_005247846                                                           16    5631
NP_005543                                                              16    7355
NP_001123579                                                           16    7355
NP_891553                                                              16    7355
NP_001248762                                                           16    7355
NP_003763                                                              16    7355
NP_001153699                                                           15    9605
NP_079413                                                              15    9605
NP_056369                                                              15    9605
XP_006720764                                                           15    9605
XP_005254752                                                           15    9605
XP_006720763                                                           15    9605
XP_006720762                                                           15    9605
XP_005254751                                                           15    9605
XP_005254356                                                           15    9605
XP_005254355                                                           15    9605
>NP_000236
          Length = 1390

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NHTAAIQSE 9
           NHTA IQSE
Sbjct: 149 NHTADIQSE 157
>NP_001120972
          Length = 1408

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NHTAAIQSE 9
           NHTA IQSE
Sbjct: 149 NHTADIQSE 157
>XP_006716052
          Length = 1409

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NHTAAIQSE 9
           NHTA IQSE
Sbjct: 168 NHTADIQSE 176
>XP_006716051
          Length = 1427

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NHTAAIQSE 9
           NHTA IQSE
Sbjct: 168 NHTADIQSE 176
>NP_002323
          Length = 4544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    NHTAAIQS 8
            NHT  IQS
Sbjct: 1218 NHTCQIQS 1225
>NP_006293
          Length = 837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NHTAAIQ 7
           NHT A+Q
Sbjct: 657 NHTKAVQ 663
>NP_001139630
          Length = 731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NHTAAIQ 7
           NHT A+Q
Sbjct: 551 NHTKAVQ 557
>NP_115763
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 980 HTAEVESE 987
>NP_115597
          Length = 2715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HTAAIQSE 9
           HT  IQSE
Sbjct: 988 HTITIQSE 995
>NP_079223
          Length = 995

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 91 HTAALQQQ 98
>XP_006723946
          Length = 1414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HTAAIQSE 9
           HT  IQSE
Sbjct: 988 HTITIQSE 995
>XP_005260632
          Length = 2377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HTAAIQSE 9
           HT  IQSE
Sbjct: 988 HTITIQSE 995
>XP_005260631
          Length = 2667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HTAAIQSE 9
           HT  IQSE
Sbjct: 940 HTITIQSE 947
>XP_005260630
          Length = 2693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HTAAIQSE 9
           HT  IQSE
Sbjct: 966 HTITIQSE 973
>XP_006722085
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 644 HTAEVESE 651
>XP_006722084
          Length = 943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 644 HTAEVESE 651
>XP_005257655
          Length = 971

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 672 HTAEVESE 679
>XP_006722083
          Length = 1233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 934 HTAEVESE 941
>XP_005257654
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 980 HTAEVESE 987
>XP_005257653
          Length = 1242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 979 HTAEVESE 986
>XP_005257652
          Length = 1279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HTAAIQSE 9
           HTA ++SE
Sbjct: 980 HTAEVESE 987
>XP_006713820
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 91 HTAALQQQ 98
>XP_005247850
          Length = 614

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 91 HTAALQQQ 98
>XP_005247848
          Length = 897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 91 HTAALQQQ 98
>XP_006713819
          Length = 925

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 91 HTAALQQQ 98
>XP_005247847
          Length = 983

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 79 HTAALQQQ 86
>XP_006713818
          Length = 999

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 79 HTAALQQQ 86
>XP_006713817
          Length = 999

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 79 HTAALQQQ 86
>XP_006713816
          Length = 999

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 79 HTAALQQQ 86
>XP_005247846
          Length = 1011

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HTAAIQSE 9
          HTAA+Q +
Sbjct: 91 HTAALQQQ 98
>NP_005543
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NHTAAIQSE 9
           NH  A++SE
Sbjct: 94  NHLNAVESE 102
>NP_001123579
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NHTAAIQSE 9
           NH  A++SE
Sbjct: 94  NHLNAVESE 102
>NP_891553
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NHTAAIQSE 9
           NH  A++SE
Sbjct: 94  NHLNAVESE 102
>NP_001248762
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NHTAAIQ 7
           NH AA+Q
Sbjct: 477 NHAAALQ 483
>NP_003763
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NHTAAIQ 7
           NH AA+Q
Sbjct: 477 NHAAALQ 483
>NP_001153699
          Length = 2330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NHTAAIQS 8
           NH+ ++QS
Sbjct: 376 NHSTSVQS 383
>NP_079413
          Length = 2443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NHTAAIQS 8
           NH+ ++QS
Sbjct: 376 NHSTSVQS 383
>NP_056369
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  NHTAAIQSE 9
          NH A  QSE
Sbjct: 66 NHVAKQQSE 74
>XP_006720764
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NHTAAIQS 8
           NH+ ++QS
Sbjct: 376 NHSTSVQS 383
>XP_005254752
          Length = 2357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NHTAAIQS 8
           NH+ ++QS
Sbjct: 290 NHSTSVQS 297
>XP_006720763
          Length = 2395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NHTAAIQS 8
           NH+ ++QS
Sbjct: 376 NHSTSVQS 383
>XP_006720762
          Length = 2397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NHTAAIQS 8
           NH+ ++QS
Sbjct: 376 NHSTSVQS 383
>XP_005254751
          Length = 2407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   NHTAAIQS 8
           NH+ ++QS
Sbjct: 376 NHSTSVQS 383
>XP_005254356
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  NHTAAIQSE 9
          NH A  QSE
Sbjct: 66 NHVAKQQSE 74
>XP_005254355
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  NHTAAIQSE 9
          NH A  QSE
Sbjct: 66 NHVAKQQSE 74
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.104    0.261 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,170
Number of extensions: 1021
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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