Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              20     299
NP_444254                                                              20     299
NP_444253                                                              20     299
NP_444255                                                              20     299
XP_005247551                                                           20     299
XP_005247550                                                           20     299
XP_006713712                                                           20     299
XP_005247549                                                           20     299
NP_055523                                                              17    4312
NP_065924                                                              17    4312
NP_001231605                                                           17    4312
XP_006719769                                                           17    4312
XP_005265408                                                           17    4312
XP_006712107                                                           17    4312
XP_005264462                                                           17    4312
XP_005264461                                                           17    4312
XP_005264460                                                           17    4312
XP_006712106                                                           17    4312
XP_006712105                                                           17    4312
XP_005264459                                                           17    4312
XP_006712104                                                           17    4312
XP_005264458                                                           17    4312
XP_005264457                                                           17    4312
NP_060741                                                              17    4312
NP_001076777                                                           16    5631
NP_004647                                                              16    7355
NP_001161147                                                           16    7355
NP_001004127                                                           16    7355
NP_001161146                                                           16    7355
NP_001171890                                                           16    7355
NP_694854                                                              16    7355
NP_055883                                                              16    7355
NP_001165908                                                           16    7355
NP_060288                                                              16    7355
NP_055325                                                              16    7355
NP_149015                                                              16    7355
NP_001243431                                                           16    7355
NP_001243432                                                           16    7355
NP_001243433                                                           16    7355
NP_001243434                                                           16    7355
XP_006715989                                                           16    7355
XP_006713145                                                           16    7355
XP_006713144                                                           16    7355
XP_005244812                                                           16    7355
XP_005244811                                                           16    7355
NP_060698                                                              16    7355
NP_877949                                                              15    9605
NP_000924                                                              15    9605
NP_001166117                                                           15    9605
NP_115946                                                              15    9605
NP_001277254                                                           15    9605
NP_054722                                                              15    9605
NP_001705                                                              15    9605
NP_001243166                                                           15    9605
XP_005260785                                                           15    9605
XP_006723635                                                           15    9605
XP_006723634                                                           15    9605
XP_006723633                                                           15    9605
XP_005260781                                                           15    9605
XP_006723632                                                           15    9605
XP_006723631                                                           15    9605
XP_005256326                                                           15    9605
XP_005253523                                                           15    9605
XP_006719197                                                           15    9605
XP_005253522                                                           15    9605
XP_006713081                                                           15    9605
NP_958925                                                              15    9605
NP_001003398                                                           15    9605
>NP_444256
          Length = 1794

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 213 NGMQVLEIH 221
>NP_444254
          Length = 1845

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 213 NGMQVLEIH 221
>NP_444253
          Length = 1914

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 213 NGMQVLEIH 221
>NP_444255
          Length = 1863

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 213 NGMQVLEIH 221
>XP_005247551
          Length = 1855

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 223 NGMQVLEIH 231
>XP_005247550
          Length = 1856

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 223 NGMQVLEIH 231
>XP_006713712
          Length = 1923

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 223 NGMQVLEIH 231
>XP_005247549
          Length = 1924

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NGMQVLEIY 9
           NGMQVLEI+
Sbjct: 223 NGMQVLEIH 231
>NP_055523
          Length = 2209

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+Q+ EI+
Sbjct: 645 NGLQLAEIF 653
>NP_065924
          Length = 716

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           +G QVL+IY
Sbjct: 522 DGTQVLKIY 530
>NP_001231605
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_006719769
          Length = 2209

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+Q+ EI+
Sbjct: 645 NGLQLAEIF 653
>XP_005265408
          Length = 716

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           +G QVL+IY
Sbjct: 522 DGTQVLKIY 530
>XP_006712107
          Length = 290

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_005264462
          Length = 370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_005264461
          Length = 377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_005264460
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_006712106
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_006712105
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_005264459
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_006712104
          Length = 423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_005264458
          Length = 484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>XP_005264457
          Length = 484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>NP_060741
          Length = 484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NGMQVLEIY 9
           NG+ VLE++
Sbjct: 97  NGLNVLELW 105
>NP_001076777
          Length = 97

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  NGMQVLEIY 9
          NG Q++EI+
Sbjct: 51 NGKQLVEIF 59
>NP_004647
          Length = 729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GMQVLEIY 9
          G+QV EIY
Sbjct: 26 GVQVEEIY 33
>NP_001161147
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 227 MQVLEIH 233
>NP_001004127
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NGMQVLE 7
           NG Q+LE
Sbjct: 108 NGQQILE 114
>NP_001161146
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 218 MQVLEIH 224
>NP_001171890
          Length = 742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NGMQVLEI 8
           NG QVL++
Sbjct: 612 NGAQVLQV 619
>NP_694854
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 220 MQVLEIH 226
>NP_055883
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NGMQVLEI 8
           NG QVL++
Sbjct: 578 NGAQVLQV 585
>NP_001165908
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NGMQVLEI 8
           NG QVL++
Sbjct: 654 NGAQVLQV 661
>NP_060288
          Length = 460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  NGMQVLEIY 9
          N +Q+L++Y
Sbjct: 37 NTLQILQLY 45
>NP_055325
          Length = 4935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    GMQVLE 7
            GMQVLE
Sbjct: 4552 GMQVLE 4557
>NP_149015
          Length = 5142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    GMQVLE 7
            GMQVLE
Sbjct: 4552 GMQVLE 4557
>NP_001243431
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 110 MQVLEIH 116
>NP_001243432
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 110 MQVLEIH 116
>NP_001243433
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 110 MQVLEIH 116
>NP_001243434
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 110 MQVLEIH 116
>XP_006715989
          Length = 5148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    GMQVLE 7
            GMQVLE
Sbjct: 4552 GMQVLE 4557
>XP_006713145
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 218 MQVLEIH 224
>XP_006713144
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQVLEI+
Sbjct: 218 MQVLEIH 224
>XP_005244812
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  NGMQVLEIY 9
          N +Q+L++Y
Sbjct: 37 NTLQILQLY 45
>XP_005244811
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  NGMQVLEIY 9
          N +Q+L++Y
Sbjct: 37 NTLQILQLY 45
>NP_060698
          Length = 702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GMQVLEI 8
          G+QVLE+
Sbjct: 52 GLQVLEV 58
>NP_877949
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>NP_000924
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>NP_001166117
          Length = 1187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>NP_115946
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GMQVLEIY 9
          G QVLE Y
Sbjct: 61 GHQVLEAY 68
>NP_001277254
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GMQVLEIY 9
          G QVLE Y
Sbjct: 61 GHQVLEAY 68
>NP_054722
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMQVLEIY 9
           GM  L+IY
Sbjct: 836 GMDALQIY 843
>NP_001705
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NGMQVLE 7
           NG+++LE
Sbjct: 411 NGLEILE 417
>NP_001243166
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NGMQVLEI 8
           NG QVL++
Sbjct: 258 NGSQVLQL 265
>XP_005260785
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3 MQVLEIY 9
         MQ++E+Y
Sbjct: 1 MQIIEMY 7
>XP_006723635
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>XP_006723634
          Length = 1187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>XP_006723633
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>XP_005260781
          Length = 1206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>XP_006723632
          Length = 1206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>XP_006723631
          Length = 1206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MQVLEIY 9
           MQ++E+Y
Sbjct: 269 MQIIEMY 275
>XP_005256326
          Length = 1192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMQVLEIY 9
           GM  L+IY
Sbjct: 801 GMDALQIY 808
>XP_005253523
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NGMQVLE 7
           NG+++LE
Sbjct: 411 NGLEILE 417
>XP_006719197
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NGMQVLE 7
           NG+++LE
Sbjct: 411 NGLEILE 417
>XP_005253522
          Length = 827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NGMQVLE 7
           NG+++LE
Sbjct: 411 NGLEILE 417
>XP_006713081
          Length = 3964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    NGMQVLEI 8
            N MQV+EI
Sbjct: 2562 NMMQVIEI 2569
>NP_958925
          Length = 90

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GMQVLEI 8
          G+QVLE+
Sbjct: 25 GLQVLEL 31
>NP_001003398
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   NGMQVLE 7
           NG+++LE
Sbjct: 411 NGLEILE 417
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.143    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,831
Number of extensions: 935
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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